BIS-Tris Propane Chemical Properties

Melting point:

164-165 °C(lit.)

Boiling point:

573.3±50.0 °C(Predicted)

Density 

1.326±0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

H₂O: 1 M at 20 °C, clear, colorless

form 

Powder/Solid

color 

White

PH

9.0-10.1 (20-25℃, 1M in water)

pka

(1) 6.8, (2) 9.0(at 25℃)

PH Range

6.3 - 9.5

Water Solubility 

Soluble in water.

BRN 

1786109

InChI

InChI=1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2

InChIKey

HHKZCCWKTZRCCL-UHFFFAOYSA-N

SMILES

C(NC(CO)(CO)CO)CCNC(CO)(CO)CO

CAS DataBase Reference

64431-96-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

22-24/25-26-36

WGK Germany 

3

HS Code 

29221980

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

BIS-Tris Propane Usage And Synthesis

Description

BIS-TRIS Propane is Good′s buffer. It acts as ligand and forms series of dinuclear hydroxo complexes with Lanthanides(III) in the pH range 7-9. It is useful for diagnostic assay manufacturing industry.

Chemical Properties

White powder

Uses

BIS-Tris Propane is a buffer that is useful in the pH 6.3 - 9.5 range. This wide buffering range is due to its two pKa values, 6.8 (pKa1) and 9.0 (pKa2), being so close. Because of the wide buffering range, particularly down to pH 6 - 7, this buffer has been used to enhance the stability or activity of restriction enzymes, compared to Tris buffer (which is a poor buffer below pH 7.5 and has a comparatively large change in pKa with temperature).

Uses

BIS-TRIS Propane may be used in the following studies:

• As buffer to investigate the influence of anions with varying nucleophilic properties on the autoxidation of oxymyoglobin (MbO₂).
• Purification of glucose-binding protein from membranes of Sulfolobus solfataricus.
• As buffer during GeO₂ mineralisation.

Definition

ChEBI: Bis-tris propane is a water-soluble buffer substance used for the preparation of the biochemical and biological buffer solutions; pKa = 6.8 at 20 ℃. It has a role as a buffer. It is functionally related to a member of tris.

Precautions

This trihydroxyamine analog, also known as bis-tris propane, presents as a white to almost white crystalline powder. Store in a cool and dark place. 1,3-Bis[tris(hydroxymethyl)methylamino]propane is known to be incompatible with oxidizing agents and should not be handled in their vicinity.

BIS-Tris Propane(64431-96-5)Related Product Information

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• Trimethylolpropane
• Tris(hydroxymethyl)aminomethane
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• Urea formaldehyde
• BIS-Tris
• Di(trimethylol propane)
• Propane
• N-ISOPROPYL-1,3-PROPANEDIAMINE
• N-METHYL-1,3-PROPANEDIAMINE
• N,N'-Dimethyl-1,3-propanediamine
• 2-Amino-2-methyl-1,3-propanediol
• N-Ethyl-1,3-propanediamine
• N,N'-Bis(2-Hydroxyethyl)propane-1,3-diamine
• 2-(HYDROXYMETHYL)-1,3-PROPANEDIOL
• 2-Amino-1,3-propanediol
• N-(2-Hydroxyethyl)-1,3-propanediamine
• 2-(PROPYLAMINO)ETHANOL