SARAFOTOXIN S6C
SARAFOTOXIN S6C Basic information
- Product Name:
- SARAFOTOXIN S6C
- Synonyms:
-
- SRTX-C
- SARAFOTOXIN S6C
- SARAFOTOXIN S6C (ATRACTASPIS ENGADDENSIS)
- Sarafotoxin C trifluoroacetate salt
- SARAFOTOXIN S6C, ATRACTASPSIS ENGADDENSIS
- SARAFOTOXIN 6C
- SARAFOTOXIN C
- SARAFOTOXIN C (ATRACTASPIS ENGADDENSIS)
- CAS:
- 121695-87-2
- MF:
- C103H147N27O37S5
- MW:
- 2515.75
- Product Categories:
-
- Peptide
- Endothelin receptor
- Mol File:
- 121695-87-2.mol
SARAFOTOXIN S6C Chemical Properties
- storage temp.
- -20°C
- solubility
- DMSO: Sparingly Soluble: 1-10 mg/ml
- form
- solid
- color
- white
- Water Solubility
- Soluble to 1 mg/ml in water
MSDS
- Language:English Provider:SigmaAldrich
SARAFOTOXIN S6C Usage And Synthesis
Uses
Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].
Biochem/physiol Actions
Sarafotoxin S6c is an endothelin ETB agonist. It is a peptide isotoxin with strong vasoconstrictor activity, obtained from the Middle Eastern snake, Atractaspis engaddensi. The toxin is composed of 21 amino acids.
in vivo
Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].
| Animal Model: | Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks[1] |
| Dosage: | 1 pM-1 mM |
| Administration: | |
| Result: | Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident. Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels. |
storage
-20°C
References
[1] MacLean MR, et al. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol. 1995 Nov;26(5):822-30. DOI:10.1097/00005344-199511000-00020
[2] CHIKAHISA TAKASAKI . Sarafotoxins S6: Several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart[J]. Toxicon, 1988, 26 6: Pages 543-548. DOI: 10.1016/0041-0101(88)90234-6
[3] DAVID L. WILLIAMS JR. Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes[J]. Biochemical and biophysical research communications, 1991, 175 2: Pages 556-561. DOI: 10.1016/0006-291x(91)91601-8
[4] J. BALWIERCZAK. Characterization of a Potent and Selective Endothelin‐B Receptor Antagonist, IRL 2500[J]. Journal of Cardiovascular Pharmacology, 1995, 26 1: S393-396. DOI: 10.1097/00005344-199506263-00116
SARAFOTOXIN S6CSupplier
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SARAFOTOXIN S6C(121695-87-2)Related Product Information
- SARALASIN
- SARAFOTOXIN S6D
- SARAFOTOXIN S6A1,SARAFOTOXIN A,SARAFOTOXIN S6A (ATRACTASPIS ENGADDENSIS),SARAFOTOXIN S6A,SARAFOTOXIN A (ATRACTASPIS ENGADDENSIS)
- SARAFOTOXIN S6B,SARAFOTOXIN S6B (ATRACTASPIS ENGADDENSIS),SARAFOTOXIN S6B ATRACTASPIS ENGADDENSIS SEQUENCE,SARAFOTOXIN B,SARAFOTOXIN B (ATRACTASPIS ENGADDENSIS)
- Dipeptide-2
- SARAFOTOXIN S6C
- (NLE6)-SARAFOTOXIN C
- Sarafotoxin S6b【reduced】
- [LYS4]-SARAFOTOXIN 6C
- H-ILE-TRP-OH
- [LYS4] SARAFOTOXIN S6C,Sarafotoxin S 6c【reduced】,Sarafotoxin c【reduced】,SARAFOTOXIN 6C, [LYS4]-
- Sarafotoxin a【reduced】,Sarafotoxin S 6a【reduced】
- Sarafotoxin S6b, Atractaspsis engaddensis
- sarafotoxin receptor
- Sarafotoxin S6d(16-21)
- [Asn4]sarafotoxin S6b【reduced】
- ANTI-SARAFOTOXIN B
- [Thr2]sarafotoxin S6b【reduced】