ChemicalBook > CAS DataBase List > 3-Amino-2,2-dimethylpropionamide

3-Amino-2,2-dimethylpropionamide

Product Name
3-Amino-2,2-dimethylpropionamide
CAS No.
324763-51-1
Chemical Name
3-Amino-2,2-dimethylpropionamide
Synonyms
Aliskiren Inter-5;3-aMino-2,2-diMethyl-;ALISKIREN InterMediates/ AM4;3-Amino-2,2-dimethylpropiomide;3-AMino-2,2-diMethylpropinaMid;3-Amino-2,2-dimethylpropanamide;3-Amino-2,2-dimethylpropionamide;PropanaMide, 3-aMino-2,2-diMethyl-;2-(aminomethyl)-2-methylpropanamide;3-amino-2,2-dimethylpropionic acid amide
CBNumber
CB01094136
Molecular Formula
C5H12N2O
Formula Weight
116.16
MOL File
324763-51-1.mol
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3-Amino-2,2-dimethylpropionamide Property

Melting point:
74-75 °C
Boiling point:
271 °C
Density 
1.004
Flash point:
117 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO, Methanol
pka
16.45±0.50(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C5H12N2O/c1-5(2,3-6)4(7)8/h3,6H2,1-2H3,(H2,7,8)
InChIKey
HKQZJXVIXAPOPZ-UHFFFAOYSA-N
SMILES
C(N)(=O)C(C)(C)CN
CAS DataBase Reference
324763-51-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
A607370
Product name
3-Amino-2,2-dimethylpropanamide
Packaging
100mg
Price
$50
Updated
2021/12/16
TRC
Product number
A607370
Product name
3-Amino-2,2-dimethylpropanamide
Packaging
5G
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0069273
Product name
3-AMINO-2,2-DIMETHYLPROPIONAMIDE
Purity
95.00%
Packaging
1G
Price
$867.1
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0069273
Product name
3-AMINO-2,2-DIMETHYLPROPIONAMIDE
Purity
95.00%
Packaging
2.5G
Price
$1255.54
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0069273
Product name
3-AMINO-2,2-DIMETHYLPROPIONAMIDE
Purity
95.00%
Packaging
5G
Price
$1590.46
Updated
2021/12/16
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3-Amino-2,2-dimethylpropionamide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

3-Amino-2,2-dimethylpropionamide is a kind of Reagent, used in the synthesis of Aliskiren.

Synthesis

7505-93-3

324763-51-1

The general procedure for the synthesis of 3-amino-2,2-dimethylpropionamide from 2-cyano-2-methylpropionamide is as follows: embodiment 5 (according to the present invention) Preparation of 3-amino-2,2-dimethylpropionamide: The product of embodiment 4 was dissolved in 840 mL of methanol-ammonia mixture (containing 169 g NH3/kg), which was subsequently transferred to an autoclave. To this was added 47.9 g of Raney Ni catalyst. The reaction mixture was stirred for hydrogenation at 60-70 °C and 5 bar hydrogen pressure for 10 hours. When analysis confirmed that the feedstock was completely consumed, the reaction mixture was filtered, the filter cake was washed with methanol, and the filtrate was subsequently evaporated to give 160 g (97% yield) of crude product. The crude product was dissolved in 800 mL of isopropanol-toluene (1:9, v/v) mixed solvent for recrystallization. Finally, 124 g (78% overall yield) of the target product 3-amino-2,2-dimethylpropionamide was obtained.

References

[1] Patent: WO2012/21446, 2012, A2. Location in patent: Page/Page column 30-31
[2] Patent: WO2010/112482, 2010, A1. Location in patent: Page/Page column 29
[3] Tetrahedron Letters, 2005, vol. 46, # 37, p. 6337 - 6340
[4] Patent: WO2011/148392, 2011, A1. Location in patent: Page/Page column 64
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 957 - 971

3-Amino-2,2-dimethylpropionamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Amino-2,2-dimethylpropionamide manufacturers

Hebei Fengjia New Material Co., Ltd
Product
3-Amino-2,2-dimethylpropionamide 324763-51-1
Price
US $6.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-08-08
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-Amino-2,2-dimethylpropionamide 324763-51-1
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-18
Shaanxi Dideu New Materials Co. Ltd
Product
3-Amino-2,2-dimethylpropionamide 324763-51-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-18

324763-51-1, 3-Amino-2,2-dimethylpropionamideRelated Search:

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  • 2-(aminomethyl)-2-methylpropanamide
  • 3-amino-2,2-dimethylpropionic acid amide
  • ALISKIREN InterMediates/ AM4
  • 3-Amino-2,2-dimethylpropanamide
  • 3-Amino-2,2-dimethylpropionamide
  • 3-AMino-2,2-diMethylpropinaMid
  • Aliskiren Inter-5
  • 3-aMino-2,2-diMethyl-
  • PropanaMide, 3-aMino-2,2-diMethyl-
  • 3-Amino-2,2-dimethylpropiomide
  • 3-Amino-2,2-dimethylpropionamide ISO 9001：2015 REACH
  • 3-Amino-2,2-dimethylpropionamide - [A12146]
  • 324763-51-1
  • Other APIs
  • Pharmaceutical intermediate
  • Amines
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • aliskiren