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IBUPROFEN SODIUM SALT

Product Name
IBUPROFEN SODIUM SALT
CAS No.
31121-93-4
Chemical Name
IBUPROFEN SODIUM SALT
Synonyms
ibuprofensodium;Einecs 250-477-6;Sodium ibuprofen;IBUPROFEN SODIUM SALT;(±)-Ibuprofen-d3, SodiuM Salt;(±)-Ibuprofen-d3 (sodium salt);p-isobutylhydratropicacidsodiumsalt;p-isobutyl-hydratropicacisodiumsalt;sodiuM 2-(4-isobutylphenyl)propanoate;sodium 2-(4-isobutylphenyl)propionate
CBNumber
CB0116983
Molecular Formula
C13H17NaO2
Formula Weight
228.26
MOL File
31121-93-4.mol
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IBUPROFEN SODIUM SALT Property

Melting point:
110-112 °C
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
H2O: 100 mg/mL, may be clear to slightly hazy
form 
Solid
color 
White to Off-White
Water Solubility 
H2O: 100mg/mL, clear to slightly hazy
Stability:
Stable. Incompatible with strong oxidizing agents
CAS DataBase Reference
31121-93-4
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
MU6641000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I1892
Product name
Ibuprofen sodium salt
Purity
analytical standard, ≥98% (GC)
Packaging
100g
Price
$196
Updated
2025/07/31
Sigma-Aldrich
Product number
I1892
Product name
Ibuprofen sodium salt
Purity
analytical standard, ≥98% (GC)
Packaging
500g
Price
$722
Updated
2025/07/31
TRC
Product number
I400158
Product name
Ibuprofen sodium salt
Packaging
500mg
Price
$85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0014433
Product name
IBUPROFEN SODIUM
Purity
95.00%
Packaging
5MG
Price
$501.28
Updated
2021/12/16
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IBUPROFEN SODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][5][8].

Application

Ibuprofen sodium salt is a useful research chemical.

Biological Activity

Cyclooxygenase (COX) inhibitor th at has greater activity against COX-1 than against COX-2.

in vivo

Ibuprofen sodium (fed in animal feedings, 300 mg/kg, 14 days) reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer[5].
Ibuprofen sodium (subcutaneous injection, 60 mg/kg, every second day for 15 days) reduces the risk of neuropathy in a rat model of chronic Oxaliplatin?induced peripheral neuropathy[6].
Ibuprofen sodium (oral administration, 20 mg/kg, every 12 hours, 5 doses total) decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise[7].
Ibuprofen sodium (oral administration, 35 mg/kg, twice daily) attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection[8].

Animal Model:Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum)[5]
Dosage:300 mg/kg, daily for 14 days
Administration:Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly)
Result:Suppresed tumor growth, reduced presence of immature monocytes and increased numbers of T cells.
Enhanced Th1 associated cytokines as well as promoted tumor border accumulation of T cells.
Animal Model:Oxaliplatin?induced peripheral neuropathy[6]
Dosage:60 mg/kg, every second day for 15 days
Administration:Subcutaneous injection
Result:Lowered sensory nerve conduction velocity (SNCV).

IC 50

COX-1: 13 μM (IC50); COX-2: 370 μM (IC50)

References

[1] Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. DOI:10.1021/np970343j
[2] Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36(5):3237-43. DOI:10.1007/s13277-014-2952-3
[3] Sharon M Rymut, et al. Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L317-27. DOI:10.1152/ajplung.00126.2016
[4] Emmanuelle Bignon, et al. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process. Sci Rep. 2017 Aug 21;7(1):8885. DOI:10.1038/s41598-017-09406-8
[5] Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6(1):98. DOI:10.1186/s40425-018-0406-y
[6] Thomas Kr?ig?rd, et al. Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy. Exp Brain Res. 2019 Oct;237(10):2645-2651. DOI:10.1007/s00221-019-05615-x
[7] Sarah Ilkhanipour Rooney, et al. Ibuprofen Differentially Affects Supraspinatus Muscle and Tendon Adaptations to Exercise in a Rat Model. Am J Sports Med. 2016 Sep;44(9):2237-45. DOI:10.1177/0363546516646377
[8] M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141(1):186-92. DOI:10.1164/ajrccm/141.1.186

IBUPROFEN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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IBUPROFEN SODIUM SALT Suppliers

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View Lastest Price from IBUPROFEN SODIUM SALT manufacturers

Dingwang Technology (Wuhan) Co., Ltd.
Product
IBUPROFEN SODIUM SALT 31121-93-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2023-02-10
Shaanxi Dideu Medichem Co. Ltd
Product
IBUPROFEN SODIUM SALT 31121-93-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-07-29

31121-93-4, IBUPROFEN SODIUM SALTRelated Search:

L-Arginine acetylsalicylate Diclofenac sodium 4-Propylphenylacetic acid 2-(4-Methylphenyl)propanoic acid IBUPROFEN SODIUM SALT Sodium phenylacetate IBUFENAC Loxoprofen sodium 2-(4-isobutylphenyl)propionaldehyde Ibuprofen 4-Methylphenylacetic acid Phenylacetic acid (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID 2-(4-ethylphenyl)acetic acid (4-ethylphenyl)acetaldehyde (2RS)-2-(4-ISOBUTYLPHENYL)PROPAN-1-OL (2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID

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