3-Pyridinemethanol,5-fluoro-(8CI,9CI)
- Product Name
- 3-Pyridinemethanol,5-fluoro-(8CI,9CI)
- CAS No.
- 22620-32-2
- Chemical Name
- 3-Pyridinemethanol,5-fluoro-(8CI,9CI)
- Synonyms
- (5-Fluoropyridin-3-yl);5-fluoronicotinyl alcohol;5-fluoropyridine-3-methanol;5-fluoro-3-PyridineMethanol;(5-Fluoro-3-pyridyl)methanol;(5-Fluoropyridin-3-yl)met...;3-Pyridinemethanol, 5-fluoro-;(5-Fluoro-3-pyridinyl)methanol;(5-Fluoro-pyridin-3-yl)-methanol;5-Fluoro-3-(hydroxymethyl)pyridine
- CBNumber
- CB01285350
- Molecular Formula
- C6H6FNO
- Formula Weight
- 127.12
- MOL File
- 22620-32-2.mol
3-Pyridinemethanol,5-fluoro-(8CI,9CI) Property
- Boiling point:
- 123 °C(Press: 0.4 Torr)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.29±0.10(Predicted)
- form
- liquid
- color
- Pale yellow
Safety
- Risk Statements
- 20/21/22-33-37/38
- Safety Statements
- 7/8-26-36/37/39-45
- RIDADR
- UN2811
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CDS021735
- Product name
- (5-Fluoro-3-pyridinyl)methanol
- Packaging
- 25mg
- Price
- $107
- Updated
- 2025/07/31
- Product number
- F596323
- Product name
- (5-Fluoropyridin-3-yl)methanol
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- PC520517
- Product name
- (5-Fluoro-3-pyridyl)methanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 068915
- Product name
- (5-Fluoro-3-pyridyl)methanol
- Purity
- >95%
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
- Product number
- 1380AB
- Product name
- (5-Fluoropyridin-3-yl)methanol
- Packaging
- 1g
- Price
- $255
- Updated
- 2021/12/16
3-Pyridinemethanol,5-fluoro-(8CI,9CI) Chemical Properties,Usage,Production
Chemical Properties
Yellow liquid
Uses
(5-Fluoropyridin-3-yl)methanol
Synthesis
402-66-4
22620-32-2
Step 1: Synthesis of (5-fluoropyridin-3-yl)methanol To a solution of 5-fluoronicotinic acid (1.0 g, 7.09 mmol) in tetrahydrofuran (THF, 10 mL) was added triethylamine (TEA, 0.9 mL, 7.73 mmol), followed by dropwise addition of ethyl chloroformate (0.6 mL, 7.73 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 2 h and then filtered and the residue was washed with a small amount of THF. The filtrate was cooled to 0 °C and sodium borohydride (0.67 g, 17.73 mmol) was added followed by slow dropwise addition of water (5 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was partitioned between ethyl acetate and water. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography to give (5-fluoropyridin-3-yl)methanol (197 mg, 21.8% yield) as a colorless oil.LCMS retention time 0.375 min; LCMS MH+ 128.
References
[1] Patent: WO2018/67786, 2018, A1. Location in patent: Page/Page column 142
[2] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 429; 430
[3] Journal of Organic Chemistry, 1988, vol. 53, # 15, p. 3513 - 3521
3-Pyridinemethanol,5-fluoro-(8CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
3-Pyridinemethanol,5-fluoro-(8CI,9CI) Suppliers
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- info@chemstep.com
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- Europe
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View Lastest Price from 3-Pyridinemethanol,5-fluoro-(8CI,9CI) manufacturers
- Product
- 3-Pyridinemethanol,5-fluoro-(8CI,9CI) 22620-32-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-20
- Product
- 3-Pyridinemethanol,5-fluoro-(8CI,9CI) 22620-32-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09