ChemicalBook > CAS DataBase List > kauran-16,17-diol
kauran-16,17-diol
- Product Name
- kauran-16,17-diol
- CAS No.
- 16836-31-0
- Chemical Name
- kauran-16,17-diol
- Synonyms
- ent-kauran;kauran-16,17-diol;ent-kauran-16β,17-diol;ent-Kaurane-16β,17-diol;Kauran-16,17-diol/16836-31-0;kauran-16,17-diol, 10 mM in DMSO;Kauran-16,17-diol (ent-Kauran-16beta,17-diol);inhibit,Inhibitor,Apoptosis,kauran16,17diol,kauran 16,17 diol;(4aR,6aS,8R,9S,11aR,11bR)-8-(Hydroxymethyl)-4,4,11b-trimethyltetradecahydro-6a,9-methanocyclohepta[a]naphthalen-8-ol
- CBNumber
- CB01308437
- Molecular Formula
- C20H34O2
- Formula Weight
- 306.48
- MOL File
- 16836-31-0.mol
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kauran-16,17-diol Property
- Melting point:
- 193-194 °C
- Boiling point:
- 422.3±18.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 14.48±0.60(Predicted)
- color
- White to off-white
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kauran-16,17-diol Chemical Properties,Usage,Production
Uses
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].
References
[1] Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52. DOI:10.1007/s10495-011-0638-5
[2] Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8. DOI:10.1016/j.bmcl.2014.11.059
kauran-16,17-diol Preparation Products And Raw materials
Raw materials
Preparation Products
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