Description Preparation
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5-Chloro-2-nitroaniline

Description Preparation
Product Name
5-Chloro-2-nitroaniline
CAS No.
1635-61-6
Chemical Name
5-Chloro-2-nitroaniline
Synonyms
5-CHLORO-2-NITROBENZENAMINE;oro-2-nitroaniL;TIMTEC-BB SBB003828;5-Chlor-2-nitroanilin;5-CHLORO-2-NITROANILINE;2-NITRO-5-CHLOROANILINE;5-Chloro-2-nitroamiline;Atorvastatin Impurity 146;Aniline, 5-chloro-2-nitro-;5-Chloro-2-nitrophenylamine
CBNumber
CB0141336
Molecular Formula
C6H5ClN2O2
Formula Weight
172.57
MOL File
1635-61-6.mol
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5-Chloro-2-nitroaniline Property

Melting point:
125-129 °C (dec.)(lit.)
Boiling point:
200°C (rough estimate)
Density 
1.5610 (rough estimate)
refractive index 
1.5870 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Chloroform, Methanol
form 
Liquid
pka
-1.46±0.25(Predicted)
color 
Clear colorless to light yellow
BRN 
2210201
InChIKey
ZCWXYZBQDNFULS-UHFFFAOYSA-N
CAS DataBase Reference
1635-61-6(CAS DataBase Reference)
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Safety

Hazard Codes 
T+,N,T
Risk Statements 
26/27/28-33-51/53
Safety Statements 
28-36/37-45-61-28A
RIDADR 
UN 2237 6.1/PG 3
WGK Germany 
3
9-23
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214210
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
269050
Product name
5-Chloro-2-nitroaniline
Purity
97%
Packaging
25g
Price
$93.7
Updated
2024/03/01
Sigma-Aldrich
Product number
269050
Product name
5-Chloro-2-nitroaniline
Purity
97%
Packaging
5g
Price
$55.6
Updated
2023/06/20
TCI Chemical
Product number
C1139
Product name
5-Chloro-2-nitroaniline
Purity
>99.0%(GC)
Packaging
25g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
C1139
Product name
5-Chloro-2-nitroaniline
Purity
>99.0%(GC)
Packaging
250g
Price
$236
Updated
2024/03/01
Alfa Aesar
Product number
A11241
Product name
5-Chloro-2-nitroaniline, 97%
Packaging
25g
Price
$84.65
Updated
2024/03/01
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5-Chloro-2-nitroaniline Chemical Properties,Usage,Production

Description

2-Nitro-5-chloroaniline is an important pharmaceutical and veterinary drug intermediate. It has been applied in the upgraded product of veterinary drug albendazole-fenbendazole, and has a broad market prospect.

Preparation

Add 2.46mol of 2,4-dichloronitrobenzene, 7.72mol of toluene to a 3L autoclave, seal the autoclave, replace the air with nitrogen, then pass in 14.1mol of liquid ammonia, increase the temperature to 160℃, continue the reaction for 8h, and then lower the temperature to 40℃, drain the excess ammonia gas, open the kettle, add the obtained solid-liquid mixture to 800mL of water, continue to cool to 10℃, filter, add the resulting filter cake to the water, continue beating and filtering, the obtained solid is crystallized with methanol to obtain 388g , yield 91.2%, the purity of the liquid phase external standard is 99.5%.

Chemical Properties

yellow to orange powder

Uses

5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel a Febantel impurity.

Uses

5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates.

Application

5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates.
The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone.

General Description

The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone.

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View Lastest Price from 5-Chloro-2-nitroaniline manufacturers

Henan Fengda Chemical Co., Ltd
Product
5-Chloro-2-nitroaniline 1635-61-6
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-24
Nanjing Fred Technology Co., Ltd
Product
5-Chloro-2-nitroaniline 1635-61-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-28
WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Chloro-2-nitroaniline 1635-61-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-24

1635-61-6, 5-Chloro-2-nitroanilineRelated Search:


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  • 1635-61-6
  • AMINE
  • Building Blocks
  • Amines
  • C2 to C6
  • Organic Building Blocks
  • Nitrogen Compounds
  • Pyrimidines
  • API intermediates