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BATRACHOTOXIN

Product Name
BATRACHOTOXIN
CAS No.
23509-16-2
Chemical Name
BATRACHOTOXIN
Synonyms
BTX;C13750;BATRACHOTOXIN;ISNYUQWBWALXEY-OMIQOYQYSA-N;Batrachotoxinin A, 20-(2,4-dimethyl-1H-pyrrole-3-carboxylate);1H-Pyrrole-3-carboxylicacid, 2,4-dimethyl-,(1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-9,12-dihydroxy-2,11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-;(1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-Dodecahydro-9,12-dihydroxy-2-11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl2,4-dimethyl-1H-pyrrole-3-carboxylate;1H-Pyrrole-3-carboxylic acid, 2,4-dimethyl-, (1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-9,12-dihydroxy-2,11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl ester
CBNumber
CB01431991
Molecular Formula
C31H42N2O6
Formula Weight
538.67
MOL File
23509-16-2.mol
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BATRACHOTOXIN Property

alpha 
24584 -5 To -10°; 24300 -260° (c = 0.23 in methanol)
Boiling point:
614.87°C (rough estimate)
Density 
1.1575 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Store at -20°C
pka
7.45(at 25℃)
form 
Thin film.
color 
Noncrystal
CAS DataBase Reference
23509-16-2
EPA Substance Registry System
Betrachotoxinin A, 20-.alpha.-(2,4-dimethyl-1H-pyrrole-3-carboxylate) (23509-16-2)
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Safety

RIDADR 
3172
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
23509-16-2(Hazardous Substances Data)
Toxicity
LD50 s.c. in mice: 2 mg/kg (Tokuyama)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
SHG0000421
Product name
BATRACHOTOXIN
Purity
95.00%
Packaging
5MG
Price
$497.89
Updated
2021/12/16
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BATRACHOTOXIN Chemical Properties,Usage,Production

Chemical Properties

Noncrystal.

Hazard

Extremely toxic; deadly poison; neurotoxic; cardiotoxic activity; bara-chotoxin that blocks neuromuscular transmission; respiratory paralysis; death.

Biological Activity

Potent neurotoxin that activates voltage-gated sodium channels. Shifts voltage-dependent activation to more negative potentials, inactivation is disabled and pore conductance and selectivity are altered (displays increased permeability for NH 4 + , K + and Cs + ions).

Safety Profile

A deadly poison byintraperitoneal, intravenous, and subcutaneous routes.When heated to decomposition it emits toxic fumes ofNOx.

Enzyme inhibitor

This lipid-soluble neurotoxin (FW = 526.67 g/mol; CAS 23509-16-2; LD50 = ~2 μg/kg mouse body weight.), isolated from the skin of the Columbian poison-dart frog Phyllobates aurotaenis, enhances Na+ conductance, promoting opening of voltage-gated Na+ channels, inducing depolarization of the resting membrane potential. It does so by binding to the sodium channel, keeping the membrane permeable to sodium ions in an all-or-none manner. This results in hyperexcitability of excitable tissues, followed by convulsions, paralysis, and death in animals. The most common use of batrachotoxin is in darts for bloguns used in hunting by the Noanamá Chocó and Emberá Chocó Indians of western Colombia. Batrachotoxin has also been identified in the feathers of the passerine birds of New Guinea Pitohui dichrous, Pitohui kirhocephalus, and Ifrita kowaldi. The less toxic batrachotoxin A is the deesterified steroid.

BATRACHOTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BATRACHOTOXIN Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Dorne Chemical Technology co. LTD
Tel
+86-86-13583358881 +8618560316533
Email
Ethan@dornechem.com
Country
China
ProdList
3096
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49978
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58

23509-16-2, BATRACHOTOXINRelated Search:


  • Batrachotoxinin A, 20-(2,4-dimethyl-1H-pyrrole-3-carboxylate)
  • C13750
  • (1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-Dodecahydro-9,12-dihydroxy-2-11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl2,4-dimethyl-1H-pyrrole-3-carboxylate
  • ISNYUQWBWALXEY-OMIQOYQYSA-N
  • BATRACHOTOXIN
  • 1H-Pyrrole-3-carboxylic acid, 2,4-dimethyl-, (1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-9,12-dihydroxy-2,11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl ester
  • BTX
  • 1H-Pyrrole-3-carboxylicacid, 2,4-dimethyl-,(1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-9,12-dihydroxy-2,11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-
  • 23509-16-2
  • Sodium channel