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Methyl 2-bromonicotinate

Product Name
Methyl 2-bromonicotinate
CAS No.
52718-95-3
Chemical Name
Methyl 2-bromonicotinate
Synonyms
methyl 2-bromonicotinate;Methyl2-Bromonicotinate>Methyl 2-bromopyridin-3-carboxylate;METHYL 2-BROMOPYRIDINE-3-CARBOXYLATE;Methyl 2-broMo-3-pyridinecarboxylate;Methyl 2-bromopyridine-3-carboxylate, 96%;2-BROMO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;2-Bromopyridine-3-carboxylic Acid Methyl Ester;3-pyridinecarboxylic acid, 2-bromo-, methyl ester;2-BROMO-3-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
CBNumber
CB0171764
Molecular Formula
C7H6BrNO2
Formula Weight
216.03
MOL File
52718-95-3.mol
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Methyl 2-bromonicotinate Property

Melting point:
32-37°C
Boiling point:
95-97 °C(Press: 1.4 Torr)
Density 
1.579±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to lump to clear liquid
pka
-1.25±0.10(Predicted)
color 
White or Colorles to Yellow to Orange
InChIKey
RAFFKXWNTXTTFO-UHFFFAOYSA-N
CAS DataBase Reference
52718-95-3
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Safety

WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
706892
Product name
Methyl 2-bromopyridine-3-carboxylate
Purity
97%
Packaging
1g
Price
$151
Updated
2023/06/20
TCI Chemical
Product number
M2449
Product name
Methyl 2-Bromonicotinate
Packaging
1G
Price
$87
Updated
2025/07/31
TCI Chemical
Product number
M2449
Product name
Methyl 2-Bromonicotinate
Packaging
5G
Price
$345
Updated
2025/07/31
TRC
Product number
M296040
Product name
Methyl 2-Bromonicotinate
Packaging
500mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR51917
Product name
Methyl 2-Bromonicotinate
Packaging
1g
Price
$41
Updated
2021/12/16
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Methyl 2-bromonicotinate Chemical Properties,Usage,Production

Synthesis

13070-22-9

105-34-0

52718-95-3

In a 500 mL three-necked flask equipped with a thermometer, 61 mL (0.5 mol) of N,N-diethyl-3-aminoacrylaldehyde, 50 mL of 95% ethanol, and 5.0 g of potassium bicarbonate (KHCO3) were added sequentially, followed by the slow addition of 65 mL (0.6 mol) of methyl cyanoacetate. The assembled reaction apparatus was placed in an ultrasonic apparatus. The ultrasonic radiation conditions were set to 60 °C reaction temperature, 250 W ultrasonic power and 150 KHz frequency to start the reaction. The reaction progress was monitored by thin layer chromatography (TLC) (unfolding agent: petroleum ether to dichloromethane 1:2 v/v, color developer: sublimated iodine) until N,N-diethyl-3-aminoacrolein was fully reacted. Subsequently, hydrogen bromide (HBr) gas was passed into the reaction system, and the reaction was maintained under the above ultrasonic radiation conditions for about 35 minutes and the reaction was tracked to completion by high performance liquid chromatography (HPLC). At the end of the reaction, the pH of the reaction solution was adjusted to 5-6 with 10% potassium hydroxide solution and left to stratify. The aqueous phase was extracted with ethyl acetate (20 mL x 3) and the organic phases were combined. The organic phase was washed with 10 mL of deionized water and dried over anhydrous sodium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to give a light brown liquid methyl 2-bromonicotinate (97.7 g) in 90.5% yield.

References

[1] Patent: CN104945317, 2018, B. Location in patent: Paragraph 0065; 0067; 0068

Methyl 2-bromonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-bromonicotinate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Methyl 2-Bromonicotinate 52718-95-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
2-Bromo-3-pyridinecarboxylic acid methyl ester 52718-95-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-05-24

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