Methyl 2-bromonicotinate
- Product Name
- Methyl 2-bromonicotinate
- CAS No.
- 52718-95-3
- Chemical Name
- Methyl 2-bromonicotinate
- Synonyms
- methyl 2-bromonicotinate;Methyl2-Bromonicotinate>Methyl 2-bromopyridin-3-carboxylate;METHYL 2-BROMOPYRIDINE-3-CARBOXYLATE;Methyl 2-broMo-3-pyridinecarboxylate;Methyl 2-bromopyridine-3-carboxylate, 96%;2-BROMO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;2-Bromopyridine-3-carboxylic Acid Methyl Ester;3-pyridinecarboxylic acid, 2-bromo-, methyl ester;2-BROMO-3-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
- CBNumber
- CB0171764
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 52718-95-3.mol
Methyl 2-bromonicotinate Property
- Melting point:
- 32-37°C
- Boiling point:
- 95-97 °C(Press: 1.4 Torr)
- Density
- 1.579±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to lump to clear liquid
- pka
- -1.25±0.10(Predicted)
- color
- White or Colorles to Yellow to Orange
- InChIKey
- RAFFKXWNTXTTFO-UHFFFAOYSA-N
- CAS DataBase Reference
- 52718-95-3
Safety
- WGK Germany
- 3
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 706892
- Product name
- Methyl 2-bromopyridine-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $151
- Updated
- 2023/06/20
- Product number
- M2449
- Product name
- Methyl 2-Bromonicotinate
- Packaging
- 1G
- Price
- $87
- Updated
- 2025/07/31
- Product number
- M2449
- Product name
- Methyl 2-Bromonicotinate
- Packaging
- 5G
- Price
- $345
- Updated
- 2025/07/31
- Product number
- M296040
- Product name
- Methyl 2-Bromonicotinate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR51917
- Product name
- Methyl 2-Bromonicotinate
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
Methyl 2-bromonicotinate Chemical Properties,Usage,Production
Synthesis
13070-22-9
105-34-0
52718-95-3
In a 500 mL three-necked flask equipped with a thermometer, 61 mL (0.5 mol) of N,N-diethyl-3-aminoacrylaldehyde, 50 mL of 95% ethanol, and 5.0 g of potassium bicarbonate (KHCO3) were added sequentially, followed by the slow addition of 65 mL (0.6 mol) of methyl cyanoacetate. The assembled reaction apparatus was placed in an ultrasonic apparatus. The ultrasonic radiation conditions were set to 60 °C reaction temperature, 250 W ultrasonic power and 150 KHz frequency to start the reaction. The reaction progress was monitored by thin layer chromatography (TLC) (unfolding agent: petroleum ether to dichloromethane 1:2 v/v, color developer: sublimated iodine) until N,N-diethyl-3-aminoacrolein was fully reacted. Subsequently, hydrogen bromide (HBr) gas was passed into the reaction system, and the reaction was maintained under the above ultrasonic radiation conditions for about 35 minutes and the reaction was tracked to completion by high performance liquid chromatography (HPLC). At the end of the reaction, the pH of the reaction solution was adjusted to 5-6 with 10% potassium hydroxide solution and left to stratify. The aqueous phase was extracted with ethyl acetate (20 mL x 3) and the organic phases were combined. The organic phase was washed with 10 mL of deionized water and dried over anhydrous sodium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to give a light brown liquid methyl 2-bromonicotinate (97.7 g) in 90.5% yield.
References
[1] Patent: CN104945317, 2018, B. Location in patent: Paragraph 0065; 0067; 0068
Methyl 2-bromonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-bromonicotinate manufacturers
- Product
- Methyl 2-Bromonicotinate 52718-95-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2-Bromo-3-pyridinecarboxylic acid methyl ester 52718-95-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-05-24