ChemicalBook > CAS DataBase List > Veratric Acid

Veratric Acid

Product Name
Veratric Acid
CAS No.
93-07-2
Chemical Name
Veratric Acid
Synonyms
VERATRIC ACID;NSC 7721;AKOS 220-15;reratric acid;VERATRIC ACID(RG);AKOS BBS-00003717;Veratrumenoic acid;Veratric acid (8CI);RARECHEM AL BO 0042;DiMethoxybenzoic aci
CBNumber
CB0176264
Molecular Formula
C9H10O4
Formula Weight
182.17
MOL File
93-07-2.mol
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Veratric Acid Property

Melting point:
179-182 °C(lit.)
Boiling point:
275.56°C (rough estimate)
Density 
1.2481 (rough estimate)
refractive index 
1.4500 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
0.5g/l
pka
4.35±0.10(Predicted)
form 
Crystalline Powder
color 
Almost white to beige or reddish
Water Solubility 
slightly soluble
Merck 
14,9953
BRN 
518285
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
DAUAQNGYDSHRET-UHFFFAOYSA-N
LogP
1.610
CAS DataBase Reference
93-07-2(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 3,4-dimethoxy-(93-07-2)
EPA Substance Registry System
Benzoic acid, 3,4-dimethoxy- (93-07-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
DG8598750
TSCA 
Yes
HS Code 
29189090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D131806
Product name
3,4-Dimethoxybenzoic acid
Purity
≥99%
Packaging
100g
Price
$86.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.45140
Product name
3,4-Dimethoxybenzoic acid
Purity
Msynth?plus
Packaging
250G
Price
$179
Updated
2022/05/15
Sigma-Aldrich
Product number
8.45140
Product name
3,4-Dimethoxybenzoic acid
Purity
Msynth?plus
Packaging
1KG
Price
$575
Updated
2022/05/15
TCI Chemical
Product number
D0631
Product name
3,4-Dimethoxybenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
D0631
Product name
3,4-Dimethoxybenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$197
Updated
2024/03/01
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Veratric Acid Chemical Properties,Usage,Production

Description

Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits and has antioxidant and anti-inflammatory activities. It also acts as a protective agent against hypertension-associated cardiovascular remodeling. Veratric acid reduces upregulated COX-2 expression and levels of PGE2 and IL-6 after UVB irradiation. This compound could be reduced to veratrine aldehyde, and alcohol was performed with enzyme extracts from a wood-degrading basidiomycete, Polystictus (Trametes) versicolor[1].

Chemical Properties

white to slightly yellow powder

Uses

3,4-Dimethoxybenzoic acid plays an important role in producing antibiotics and various dyes. They are used as intermediates for pharmaceuticals (especially for antipyretic analgesic, antirheumatism) and other organic synthesis. It is used as matrix for ionization of peptides, proteins and carbohydrates.

Uses

3,4-Dimethoxybenzoic acid is a derivative of Protocatechuic Acid.3,4-Dimethoxybenzoic acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.

Definition

ChEBI: A member of the class of benzoic acids that is benzoic acid substituted by methoxy groups at positions 2 and 3.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 26, p. 299, 1978 DOI: 10.1248/cpb.26.299
Tetrahedron Letters, 43, p. 4985, 2002 DOI: 10.1016/S0040-4039(02)00929-2

in vitro

Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation, and HDAC3 expression in RAW264.7 cells.
Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis.
Veratric acid reduces upregulated COX-2 expression and levels of PGE2, and IL-6 after UVB irradiation.

Purification Methods

Crystallise the acid from Et2O, H2O or aqueous acetic acid. It has m 180-181o after sublimation at 80o/1mm. [Beilstein 10 H 393, 10 I 188, 10 II 261, 10 III 1404, 10 IV 1406.]

References

[1] Gross, Georg G. “From lignins to tannins: Forty years of enzyme studies on the biosynthesis of phenolic compounds.” Phytochemistry 69 18 (2008): Pages 3018-3031.

Veratric Acid Preparation Products And Raw materials

Raw materials

Preparation Products

5,6-DIMETHOXYISOBENZOFURAN-1(3H)-ONE
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Veratric Acid Suppliers

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View Lastest Price from Veratric Acid manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
3,4-Dimethoxybenzoic acid 93-07-2
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000kg
Release date
2024-05-14
Jinan Finer Chemical Co., Ltd
Product
3,4-Dimethoxybenzoic acid 93-07-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
100mt/year
Release date
2021-07-08
Hebei Weibang Biotechnology Co., Ltd
Product
3,4-Dimethoxybenzoic acid 93-07-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-10-31

93-07-2, Veratric AcidRelated Search:

3-Methoxybenzoic acid 2-Methoxybenzoic acid 2,6-Dimethoxybenzaldehyde Dimethoxymethane Folic acid 1,1-Dimethoxyethane Glycine Dimethyldimethoxysilane Citric acid Ethyl 2-(Chlorosulfonyl)acetate 4-Methoxybenzoic acid Diphenyldimethoxysilane 4-[2-(DIMETHYLAMINO)ETHOXY]BENZONITRILE Itopride N-Oxide ETHYL 3,4-DIMETHOXYBENZOATE 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE 3,4-DIMETHOXYBENZOYL CHLORIDE Ascoric Acid Veratric Acid

  • NSC 7721
  • Protocatechuic Acid Dimethyl Ether Veratric Acid
  • (2R)-2,7,8-Trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
  • 3,4-DiMethoxybenzoic acid, 99+% 100GR
  • 3,4-DIMETHOXYBENZOIC ACID FOR SYNTHESIS
  • DiMethoxybenzoic aci
  • 3,4- twoMethoxybenzoic acid
  • 3,4-DIMETHOXYBENZOIC ACID (VERATRIC ACID)
  • 3,4-Bis(methyloxy)benzoic acid
  • Veratric acid (8CI)
  • 3,4-DIMETHOXYBENZOIC ACID, 99+%
  • 3,4-DIMETHOXYENZIOC ACID
  • 3,4-DimethoxbenzoicAcid99%
  • 3,4-Dimethoxybenzoic
  • Benzoic acid, 3,4-dimethoxy-
  • VERATRIC ACID(RG)
  • reratric acid
  • 3,4-DIMETHOXY BENZOIC ACID (VERATRIC ACID) ,99+%
  • 3,4-Dimethoxybenzoic acid≥ 99% (Titration)
  • DIMETHYLPROTOCATECHUIC ACID
  • RARECHEM AL BO 0042
  • PROTOCATECHUIC ACID DIMETHYL ETHER
  • 3,4-DIMETHOXYBENZOIC ACID
  • AKOS 220-15
  • AKOS BBS-00003717
  • VERATRIC ACID
  • 3,4-dimethoxy-benzoicaci
  • 3,4-Dimethylprotocatechuic acid
  • 3,4-dimethylprotocatechuicacid
  • Veratrumenoic acid
  • 3,4-Dimethoxybenzoic Acid &gt
  • 3,4-Dimethoxybenzoic Acid (Veratric
  • Mebeverine Impurity D
  • Itopride Impurity 15
  • Mebeverine EP Impurity D
  • 3,4-Dimethoxy benzoic acid (Veratric acid- 98%)
  • Veratric acid（3,4-Dimethoxybenzoic acid）
  • 3,4-Dimethoxybenzoic acid CAS：93-07-2
  • Mebeverine Hydrochloride Impurity D
  • Mebeverine Hydrochloride EP Impurity D
  • VERATRIC ACID ITOPRIDE/MEBEVERINE
  • Resulinic acid (3, 4-dimethoxybenzoic acid)
  • 93-07-2
  • 1993-7-2
  • 93-7-2
  • 1993-07-2
  • 193-07-2
  • 34152
  • CAS:1993-07-2
  • CH3O2C6H3COOH
  • CH3O2C6H3CO2H
  • Building Blocks
  • C9
  • Carboxylic Acids
  • Carbonyl Compounds
  • Organic Building Blocks
  • intermediate
  • Aromatics