6-O-Methyl-guanine
- Product Name
- 6-O-Methyl-guanine
- CAS No.
- 20535-83-5
- Chemical Name
- 6-O-Methyl-guanine
- Synonyms
- NSC 37364;O-METHYLGUANINE;O6-METHYLGUANINE;6-Methoxyguanine;6-O-Methylguanine;o(sup6)-methylguanine;6-O-Methylguanine 97%;Aminomethoxypurine,97%;Nelarabine Impurity 11;2-AMINO-6-METHOXYPURINE
- CBNumber
- CB0177812
- Molecular Formula
- C6H7N5O
- Formula Weight
- 165.15
- MOL File
- 20535-83-5.mol
6-O-Methyl-guanine Property
- Melting point:
- >300 °C(lit.)
- Boiling point:
- 598.5±53.0 °C(Predicted)
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly, Heated), Water (Slightly, Heated)
- form
- Solid
- pka
- 9.74±0.10(Predicted)
- color
- Off-White to Pale Yellow
- BRN
- 645384
- InChI
- InChI=1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
- InChIKey
- BXJHWYVXLGLDMZ-UHFFFAOYSA-N
- SMILES
- N1C2C(=NC(N)=NC=2OC)NC=1
- CAS DataBase Reference
- 20535-83-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 363057
- Product name
- 6-O-Methylguanine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $156.5
- Updated
- 2025/07/31
- Product number
- PHR1719
- Product name
- 6-O-Methylguanine
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $141
- Updated
- 2024/03/01
- Product number
- A1151
- Product name
- 2-Amino-6-methoxypurine
- Purity
- >97.0%(T)
- Packaging
- 100mg
- Price
- $68
- Updated
- 2025/07/31
- Product number
- M311800
- Product name
- 6-O-Methylguanine
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 016882
- Product name
- 6-O-Methylguanine
- Packaging
- 10mg
- Price
- $340
- Updated
- 2021/12/16
6-O-Methyl-guanine Chemical Properties,Usage,Production
Chemical Properties
Off-white solid
Uses
Antitumor agent
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Definition
ChEBI: A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.
Application
6-O-Methyl-guanine is a key molecular tool for studying DNA damage, repair mechanisms, and cancer chemotherapy. It is a potent mutagenic and carcinogenic DNA damage product induced by alkylating agents (such as certain environmental carcinogens and chemotherapeutic drugs). It can mispair with thymine (T), leading to G:C to A:T base transition mutations during DNA replication. Therefore, O⁶-MeG is widely used in in vitro and cellular experiments to simulate DNA damage states and study how cells remove this damage through repair proteins such as O⁶-methylguanine-DNA methyltransferase (MGMT).
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
6-O-Methyl-guanine Preparation Products And Raw materials
Raw materials
Preparation Products
6-O-Methyl-guanine Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from 6-O-Methyl-guanine manufacturers
- Product
- 6-Methoxyguanine 20535-83-5
- Price
- US $3.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-16
- Product
- 6-Methoxyguanine 20535-83-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
- Product
- 6-O-Methylguanine 20535-83-5
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11