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Oxybutynin hydrochloride

Product Name
Oxybutynin hydrochloride
CAS No.
1508-65-2
Chemical Name
Oxybutynin hydrochloride
Synonyms
Tropax;Cystrin;Dridase;Inobase;mj4309-1;ditropan;MJ 50-58;Pollakisu;Oxybutynin HC;OXYBUTYNIN HCL
CBNumber
CB0178112
Molecular Formula
C22H32ClNO3
Formula Weight
393.95
MOL File
1508-65-2.mol
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Oxybutynin hydrochloride Property

Melting point:
122-124°C
storage temp. 
room temp
solubility 
H2O: soluble50mg/mL
form 
powder
color 
white
CAS DataBase Reference
1508-65-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
GV2800000
HS Code 
29221990
Toxicity
LD50 orally in rats: 1220 mg/kg (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2547
Product name
Oxybutynin Chloride
Packaging
500MG
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
O2881
Product name
Oxybutynin chloride
Purity
≥98% (TLC), powder
Packaging
1g
Price
$88.2
Updated
2024/03/01
Sigma-Aldrich
Product number
1485103
Product name
Oxybutynin chloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
23825
Product name
Oxybutynin (hydrochloride)
Purity
≥98%
Packaging
1g
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
23825
Product name
Oxybutynin (hydrochloride)
Purity
≥98%
Packaging
5g
Price
$210
Updated
2024/03/01
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Oxybutynin hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Ditropan, Marion , US ,1975

Uses

An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells

Uses

anticholinergic

Uses

An antagonist of M1, M2, & M3 muscarinic acetylcholine receptors

Manufacturing Process

A mixture of 394.2 grams of methyl phenylcyclohexylglycolate and 293.1 grams of 4-diethylamino-2-butynyl acetate was dissolved with warming in 2.6 liters of n-heptane. The solution was heated with stirring to a temperature of 60° to 70°C and 8.0 grams of sodium methoxide were added. The temperature of the mixture was then raised until the solvent began to distill. Distillation was continued at a gradual rate and aliquots of the distillate were successively collected and analyzed for the presence of methyl acetate by measurement of the refractive index. The reaction was completed when methyl acetate no longer distilled, and the refractive index observed was that of pure heptane (nD26 = 1.3855). About 3? hours were required for the reaction to be completed.
The reaction mixture was then allowed to cool to room temperature, washed with water, and extracted with four 165 ml portions of 2 N hydrochloric acid. The aqueous extracts were combined and stirred at room temperature to permit crystallization of the hydrochloride salt of the desired product. Crystallization was completed by cooling the slurry in an ice bath, and the product was collected by filtration, pressed dry, and recrystallized from 750 ml of water. Yield of pure crystalline material, 323 grams.

brand name

Ditropan (ALZA).

Therapeutic Function

Spasmolytic

Biological Activity

oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

Biochem/physiol Actions

Muscarinic acetylcholine receptor antagonist; inhibits proliferation of bladder smooth muscle cells, perhaps by downregulation of growth promoting genes.

Clinical Use

Urinary frequency, urgency and incontinence
Neurogenic bladder instability and nocturnal enuresis

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. An eye irritant. Human systemic effects: coma, mydriasis, rate changes. An anticholinergic agent. When heated to decomposition it e

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.
Other antimuscarinic agents: increased antimuscarinic effects.

Metabolism

Oxybutynin undergoes extensive first-pass metabolism, particularly by the cytochrome P450 isoenzyme
CYP3A4. One of the metabolites, N-desethyloxybutynin is pharmacologically active.
Oxybutynin and its metabolites are excreted in the urine and faeces.

Oxybutynin hydrochloride Preparation Products And Raw materials

Raw materials

Cyclohexanol

Preparation Products

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View Lastest Price from Oxybutynin hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Oxybutynin hydrochloride 1508-65-2
Price
US $0.00/Kg/Bag
Min. Order
100g
Purity
99%-102%
Supply Ability
10kgs
Release date
2021-08-03
Shaanxi Dideu Medichem Co. Ltd
Product
Oxybutynin hydrochloride 1508-65-2
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08
Hebei Yanxi Chemical Co., Ltd.
Product
Oxybutynin hydrochloride 1508-65-2
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-18

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