Alantolactone

Product Name: Alantolactone
CAS No.: 546-43-0
Chemical Name: Alantolactone
Synonyms: HELENINE;ALANTOLACETONE;Alantolactone/Helenine;4a.H-Eudesma-5,11(13)-dien-12-oic acid, 8b-hydroxy-, g-lactone;helenin;Eupatal;NSC 93131;NSC 333843;Alant camphor;ALANTOLACTONE
CBNumber: CB0194433
Molecular Formula: C15H20O2
Formula Weight: 232.32
MOL File: 546-43-0.mol

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Alantolactone Property

Melting point:: 78-79 C
Boiling point:: 275 C
alpha: D +175° (chloroform)
Density: 1.0610 (rough estimate)
refractive index: 1.4360 (estimate)
storage temp.: -20°C
solubility: DMSO: soluble15mg/mL (clear solution)
form: powder
color: white to beige
LogP: 3.380
CAS DataBase Reference: 546-43-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-43
Safety Statements: 26-36-36/37-24/25
WGK Germany: 3
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0415
Product name: Alantolactone
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $67.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0415
Product name: Alantolactone
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $441
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89156
Product name: Alantolactone
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $430
Updated: 2024/03/01

Cayman Chemical

Product number: 29762
Product name: Alantolactone
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 29762
Product name: Alantolactone
Packaging: 10mg
Price: $116
Updated: 2024/03/01

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Alantolactone Chemical Properties,Usage,Production

Description

The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone-mix, used to detect sensitization to Compositae.

Chemical Properties

Crystalline powder

Uses

anthelmintic, antibacterial, antineoplastic

Uses

Alantolactone has been used:

in cell viability assay
to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
in assessment of degranulation

Uses

Alantolactone is sesquiterpene lactone that possesses anti-inflammatory property. Alantolactone have been studied to be developed as a novel agent against human liver cancer.

Definition

ChEBI: A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.

Contact allergens

The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone mix used to detect sensitization to Compositae-Asteraceae.

storage

Store at -20°C

Alantolactone Preparation Products And Raw materials

Raw materials

Preparation Products

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Alantolactone Suppliers

Canada 2 China 230 Europe 3 France 1 Germany 2 India 3 South Korea 1 United Kingdom 7 United States 28 USA 1 Global 278

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View Lastest Price from Alantolactone manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Alantolactone 546-43-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

R&D Scientific Inc.

Product: Alantolactone 546-43-0
Price: US $580.00/g
Min. Order: 1g
Purity: 97
Supply Ability: 500 Kg
Release date: 2024-03-31

Anhui Ruihan Technology Co., Ltd

Product: Alantolactone 546-43-0
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000tons
Release date: 2023-08-22

546-43-0, AlantolactoneRelated Search:

ε-Caprolactone N,N-Dimethylacetamide ETHANE Dimethyl sebacate Dimethyl sulfate Dimethyl ether Dimethyl fumarate CHLOROPHOSPHONAZO III Dimethyl carbonate N,N-Dimethylformamide Dacthal Hyaluronic acid Dimethyl sulfoxide Dimethyl sulfone Ethyl 2-(Chlorosulfonyl)acetate Dichlorodimethylsilane Dimethyl sulfide Folic acid

HELENINE

8b-hydroxy-4ah-eudesm-5-en-12-oic acid

ALLANTOLACTONE

ALANTOLACETONE

ALANTOLACTONE

[3ar-(3aa,5b,8ab,9aa)]-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho-[2,3-b]furan-2(3h)-one

[3aR-(3aalpha,5beta,8abeta,9aalpha)]-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one

Alantolactone (Helenin)

helenin

4αH-Eudesma-5,11(13)-dien-12-oic acid, 8β-hydroxy-, γ-lactone (8CI)

Alant camphor

Alantolactone (6CI)

Elecampane camphor

Eupatal

Helenin (7CI)

Inula camphor

Naphtho[2,3-b]furan-2(3H)-one, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aR,5S,8aR,9aR)-

Naphtho[2,3-b]furan-2(3H)-one, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, [3aR-(3aα,5β,8aβ,9aα)]-

NSC 93131

8b-hydroxy-4aH-eudesm-s-en-12-oic acid

Naphtho[2,3-b]furan-2(3H)-one,3a,5,6,7,8,8a,9,9a-

octahydro-5,8a-dimethyl-3-methylene-,(3aR,5S,8aR,9aR)-

4a.H-Eudesma-5,11(13)-dien-12-oic acid, 8b-hydroxy-, g-lactone

(3aR)-3a,5,6,7,8,8a,9,9aα-Octahydro-5β,8aβ-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one

(3aR)-3aα,5,6,7,8,8a,9,9aα-Octahydro-5β,8aβ-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one

ALANTOLACTONE(RG)

Alantolactone/Helenine

Alantic anhydride

NSC 333843

3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one

Alantolactone, 98%, from Inula helenium L.

(3aR,5S,8aR,9aR)-5,8a-Dimethyl-3-methylene-3,3a,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(5H)-one

Alantolactone USP/EP/BP

Alantolactone Inula camphor

3aR-(3a?,5?,8a?,9a?)]-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one

(+)-Alantolactone

hymenolactone

546-43-0

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Alkaloids

chiral