MG-115

Product Name: MG-115
CAS No.: 133407-86-0
Chemical Name: MG-115
Synonyms: MG-115;Z-LLnV;(S)-MG115;Z-LL-NVA-CHO;MG115, Z-LLnV;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;z-leu-leu-norvalinal;Z-LEU-LEU-NVA-ALDEHYDE;MG-115 (DMSO solution)
CBNumber: CB0195607
Molecular Formula: C25H39N3O5
Formula Weight: 461.59
MOL File: 133407-86-0.mol

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MG-115 Property

Boiling point:: 678.8±55.0 °C(Predicted)
Density: 1.082±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble
form: powder
pka: 11.14±0.46(Predicted)
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 474780
Product name: MG-115
Purity: Potent reversible proteasome inhibitor (K
Packaging: 5mg
Price: $259
Updated: 2024/03/01

Sigma-Aldrich

Product number: C6706
Product name: Z-Leu-Leu-Norvalinal
Purity: ≥90% (HPLC), powder
Packaging: 1mg
Price: $99.3
Updated: 2023/06/20

Cayman Chemical

Product number: 15413
Product name: (S)-MG115
Purity: ≥95%
Packaging: 1mg
Price: $51
Updated: 2024/03/01

Cayman Chemical

Product number: 15413
Product name: (S)-MG115
Purity: ≥95%
Packaging: 5mg
Price: $128
Updated: 2024/03/01

Cayman Chemical

Product number: 15413
Product name: (S)-MG115
Purity: ≥95%
Packaging: 10mg
Price: $229
Updated: 2024/03/01

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MG-115 Chemical Properties,Usage,Production

Description

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (K_i = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

Uses

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]

Uses

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

Definition

ChEBI: N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.

General Description

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Biochem/physiol Actions

Product does not compete with ATP.

References

1. involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. imamura, t., haruta, t., takata, y., usui, i., iwata, m., ishihara, h., ishiki, m., ishibashi, o., ueno, e., sasaoka, t., kobayashi, m. j. biol. chem. (1998)

MG-115 Preparation Products And Raw materials

Raw materials

Preparation Products

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MG-115 Suppliers

China 65 Germany 2 Japan 2 Switzerland 2 United Kingdom 3 United States 14 USA 1 Global 89

ApexBio Technology LLC

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133407-86-0, MG-115Related Search:

Trypsin trysin-chymotrypsin Basic protease LACTACYSTIN MG-115 MG-132 Z-LLL-AMC Z-LEU-LEU-ARG-AMC Z-LEU-LEU-4,5-DEHYDRO-LEU-ALDEHYDE Z-LEU-LEU-GLU-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN MG-262 Z-LEU-LEU-GLU-AMC Z-LEU-LEU-LEU-FMK N-CBZ-LEU-LEU-GLU BETA-NAPHTHYLAMIDE GAMMA-SECRETASE INHIBITOR 1 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) 5 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE)

PROTEASOME INHIBITOR MG-115

N-CBZ-LEU-LEU-NORVALINAL

MG-115

Z-LL-NVA-CHO

Z-LEU-LEU-NVA-ALDEHYDE

Z-LEU-LEU-NVA-CHO

Z-LEU-LEU-NVA-H

Z-LEU-LEU-NVA-H (ALDEHYDE)

CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-NORVALINAL

CARBOBENZOXY-L-LEUCYL-L-LEUCYL-NORVALINAL

BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-NORVALINAL

z-leu-leu-norvalinal

N-carbobenzyloxy-Leu-Leu-norvalinal

MG115, Z-LLnV

Z-Leu-Leu-Norvalinal,MG115, Z-LLnV

(S)-MG115

MG-115 (DMSO solution)

Z-LLnV

MG-115 - CAS 133407-86-0 - Calbiochem

L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-

Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxopentan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate

133407-86-0

C25H39N3O5

Inhibitors

BioChemical

Biochemicals and Reagents

Application Index

Cell Signaling Enzymes

Proteasome, Calpain and Lysosomal Proteases

Proteasomes

Enzymes, Inhibitors, and Substrates

Calpain and Lysosomal Proteases

Proteasome Inhibitors

Aldehydes

and Substrates

Application Index

Bioactive Small Molecules

Biochemicals and Reagents

Building Blocks

C13-C60

Calpain and Proteasome Inhibitors

Carbonyl Compounds

Cell Biology

Cell Signaling and Neuroscience

Cell Signaling Enzymes

Chemical Synthesis

Endoplasmic Reticulum Stress

Enzymes

Inhibitors

Intracellular Protein Degradation

Nitric Oxide and Cell Stress

Organic Building Blocks

Proteasome

Proteasomes

Z

ProteasomeInhibitors

peptides