ChemicalBook > CAS DataBase List > Formoterol fumarate dihydrate

Formoterol fumarate dihydrate

Product Name
Formoterol fumarate dihydrate
CAS No.
183814-30-4
Chemical Name
Formoterol fumarate dihydrate
Synonyms
Formoterol fumarate dihydrate;Unii-W34shf8J2k;Formoterol hemifumar;forMaMide fuMarate dihydrate;Formoterol Fumarate (100 mg);Formoterol fumarate 2-hydrate;Arformoterol Fumarate Dihydrate;Formoterol Hemifumarate Dihydrate;Formoterol hemifumarate monohydrate;Formoterol fumarate dihydrate, >=99%
CBNumber
CB02130563
Molecular Formula
C23H28N2O8
Formula Weight
460.48
MOL File
183814-30-4.mol
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Formoterol fumarate dihydrate Property

Melting point:
116-120°C
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL
form 
solid
color 
white to off-white
InChIKey
RATSWNOMCHFQGJ-XODSYJLDSA-N
SMILES
C(/C(=O)O)=C\C(=O)O.[C@@H](C1C=CC(O)=C(NC=O)C=1)(O)CN[C@@H](C)CC1C=CC(OC)=CC=1 |&1:8,22,r|
CAS DataBase Reference
183814-30-4
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Safety

RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H332Harmful if inhaled

H370Causes damage to organs

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F9552
Product name
Formoterol fumarate dihydrate
Purity
>98% (HPLC)
Packaging
10mg
Price
$221
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2703
Product name
Formoterol fumarate
Purity
PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial,certifiedrefer
Packaging
500MG
Price
$400
Updated
2024/03/01
Sigma-Aldrich
Product number
F0372000
Product name
Formoterol fumarate dihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
10mg
Price
$181
Updated
2022/05/15
Sigma-Aldrich
Product number
F9552
Product name
Formoterol fumarate dihydrate
Purity
>98% (HPLC)
Packaging
50mg
Price
$761
Updated
2024/03/01
Sigma-Aldrich
Product number
F0372000
Product name
Formoterol fumarate dihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
f0372000
Price
$153
Updated
2024/03/01
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Formoterol fumarate dihydrate Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Formoterol is a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic.

Uses

ForMoterol FuMarate Dihydrate is a selective β2-adrenergic receptor agonist,it is used as an antiasthmatic.

Biological Activity

Potent, selective and long-acting β 2 -adrenoceptor agonist. Displays 330-fold selectivity for β 2 over β 1 receptors (pK d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD 2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.

Biochem/physiol Actions

β2-Adrenoreceptor agonist.

Drug interactions

The efficacy and tolerability of glycopyrronium/formoterol fumarate metered dose inhaler, a fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate 14.4/10 μg (equivalent to glycopyrrolate/formoterol fumarate 18/9.6 μg) delivered by metered dose inhaler using innovative co-suspension delivery technology, was investigated in patients (n = 292) with COPD [12C]. There were no meaningful pharmacokinetic interactions, whether drug–drug or due to formulation, between glycopyrronium and formoterol following treatment with formulated using a new co-suspension delivery technology. The incidence of cardiovascular events of special interest was low (stroke, 0%–0.4%; cardiac ischemia, 0.4%–2.3%; cardiac failure, 1.3%–2.5%; arrhythmia, 1.3%–3.2%), and no important trends in clinical laboratory results, vital signs, or electrocardiograms were observed[1].

References

[1] Aagaard, Lise . "A worldwide yearly survey of new data in adverse drug reactions." (2014).

Formoterol fumarate dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Formoterol fumarate dihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Formoterol Fumarate Monohydrate/ dihydrate 183814-30-4
Price
US $0.00/g/Bag
Min. Order
10g
Purity
98.5%min; JP14
Supply Ability
20kg/month
Release date
2021-06-03
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Formoterol Fumarate Dihydrate 183814-30-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 TONS
Release date
2022-11-07
Zibo Hangyu Biotechnology Development Co., Ltd
Product
(R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate dihydrate 183814-30-4
Price
US $65.00-650.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-20

183814-30-4, Formoterol fumarate dihydrateRelated Search:

CHLOROPHOSPHONAZO III Chlorantraniliprole 1-Hydroxyethylidene-1,1-diphosphonic acid Arformoterol tartrate Fumaric acid Dimethyl fumarate Formoterol Ketotifen fumarate Benzamide 4-Ethyl-5-fluoro-6-hydroxypyrimidine N,N-Dimethylformamide Formamide Ferrous fumarate Formoterol fumarate FOROXYMITHINE FUMARATE Formoterol fumarate dihydrate

  • Formamide, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, rel-, (2E)-2-butenedioate (2:1) (salt), dihydrate
  • Unii-W34shf8J2k
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  • Formoterol fumarate dihydrateQ: What is Formoterol fumarate dihydrate Q: What is the CAS Number of Formoterol fumarate dihydrate Q: What is the storage condition of Formoterol fumarate dihydrate
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