Formoterol fumarate dihydrate
- Product Name
- Formoterol fumarate dihydrate
- CAS No.
- 183814-30-4
- Chemical Name
- Formoterol fumarate dihydrate
- Synonyms
- Formoterol fumarate dihydrate;Unii-W34shf8J2k;Formoterol hemifumar;forMaMide fuMarate dihydrate;Formoterol Fumarate (100 mg);Formoterol fumarate 2-hydrate;Arformoterol Fumarate Dihydrate;Formoterol hemifumarate monohydrate;Formoterol fumarate dihydrate, >=99%;Formoterol fumarate dihydrate ,98.5%
- CBNumber
- CB02130563
- Molecular Formula
- C23H28N2O8
- Formula Weight
- 460.48
- MOL File
- 183814-30-4.mol
Formoterol fumarate dihydrate Property
- Melting point:
- 116-120°C
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL
- form
- solid
- color
- white to off-white
- InChIKey
- RATSWNOMCHFQGJ-XODSYJLDSA-N
- SMILES
- C(/C(=O)O)=C\C(=O)O.[C@@H](C1C=CC(O)=C(NC=O)C=1)(O)CN[C@@H](C)CC1C=CC(OC)=CC=1 |&1:8,22,r|
- CAS DataBase Reference
- 183814-30-4
Safety
- RIDADR
- UN 2811 6.1 / PGII
- WGK Germany
- 3
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H332Harmful if inhaled
H370Causes damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
N-Bromosuccinimide Price
- Product number
- F9552
- Product name
- Formoterol fumarate dihydrate
- Purity
- >98% (HPLC)
- Packaging
- 10mg
- Price
- $221
- Updated
- 2024/03/01
- Product number
- PHR2703
- Product name
- Formoterol fumarate
- Purity
- PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial,certifiedrefer
- Packaging
- 500MG
- Price
- $400
- Updated
- 2024/03/01
- Product number
- F0372000
- Product name
- Formoterol fumarate dihydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 10mg
- Price
- $181
- Updated
- 2022/05/15
- Product number
- F9552
- Product name
- Formoterol fumarate dihydrate
- Purity
- >98% (HPLC)
- Packaging
- 50mg
- Price
- $761
- Updated
- 2024/03/01
- Product number
- F0372000
- Product name
- Formoterol fumarate dihydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- f0372000
- Price
- $153
- Updated
- 2024/03/01
Formoterol fumarate dihydrate Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
Formoterol is a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic.
Uses
ForMoterol FuMarate Dihydrate is a selective β2-adrenergic receptor agonist,it is used as an antiasthmatic.
Biological Activity
Potent, selective and long-acting β 2 -adrenoceptor agonist. Displays 330-fold selectivity for β 2 over β 1 receptors (pK d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD 2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.
Biochem/physiol Actions
β2-Adrenoreceptor agonist.
Drug interactions
The efficacy and tolerability of glycopyrronium/formoterol fumarate metered dose inhaler, a fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate 14.4/10 μg (equivalent to glycopyrrolate/formoterol fumarate 18/9.6 μg) delivered by metered dose inhaler using innovative co-suspension delivery technology, was investigated in patients (n = 292) with COPD [12C]. There were no meaningful pharmacokinetic interactions, whether drug–drug or due to formulation, between glycopyrronium and formoterol following treatment with formulated using a new co-suspension delivery technology. The incidence of cardiovascular events of special interest was low (stroke, 0%–0.4%; cardiac ischemia, 0.4%–2.3%; cardiac failure, 1.3%–2.5%; arrhythmia, 1.3%–3.2%), and no important trends in clinical laboratory results, vital signs, or electrocardiograms were observed[1].
References
[1] Aagaard, Lise . "A worldwide yearly survey of new data in adverse drug reactions." (2014).
Formoterol fumarate dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Formoterol fumarate dihydrate manufacturers
- Product
- (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate dihydrate 183814-30-4
- Price
- US $65.00-650.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-20
- Product
- Formoterol fumarate dihydrate 183814-30-4
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 99
- Supply Ability
- 20kg/month
- Release date
- 2024-04-15
- Product
- Formoterol Fumarate Dihydrate 183814-30-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 TONS
- Release date
- 2022-11-07