Formoterol fumarate dihydrate
- Product Name
- Formoterol fumarate dihydrate
- CAS No.
- 183814-30-4
- Chemical Name
- Formoterol fumarate dihydrate
- Synonyms
- Formoterol fumarate dihydrate;Unii-W34shf8J2k;Formoterol hemifumar;forMaMide fuMarate dihydrate;Formoterol Fumarate (100 mg);Formoterol fumarate 2-hydrate;Arformoterol Fumarate Dihydrate;Formoterol Hemifumarate Dihydrate;Formoterol hemifumarate monohydrate;Formoterol fumarate dihydrate, >=99%
- CBNumber
- CB02130563
- Molecular Formula
- C23H28N2O8
- Formula Weight
- 460.48
- MOL File
- 183814-30-4.mol
Formoterol fumarate dihydrate Property
- Melting point:
- 116-120°C
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL
- form
- solid
- color
- white to off-white
- InChIKey
- RATSWNOMCHFQGJ-XODSYJLDSA-N
- SMILES
- C(/C(=O)O)=C\C(=O)O.[C@@H](C1C=CC(O)=C(NC=O)C=1)(O)CN[C@@H](C)CC1C=CC(OC)=CC=1 |&1:8,22,r|
- CAS DataBase Reference
- 183814-30-4
Safety
- RIDADR
- UN 2811 6.1 / PGII
- WGK Germany
- 3
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H332Harmful if inhaled
H370Causes damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
N-Bromosuccinimide Price
- Product number
- F9552
- Product name
- Formoterol fumarate dihydrate
- Purity
- >98% (HPLC)
- Packaging
- 10mg
- Price
- $221
- Updated
- 2024/03/01
- Product number
- PHR2703
- Product name
- Formoterol fumarate
- Purity
- PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial,certifiedrefer
- Packaging
- 500MG
- Price
- $400
- Updated
- 2024/03/01
- Product number
- F0372000
- Product name
- Formoterol fumarate dihydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 10mg
- Price
- $181
- Updated
- 2022/05/15
- Product number
- F9552
- Product name
- Formoterol fumarate dihydrate
- Purity
- >98% (HPLC)
- Packaging
- 50mg
- Price
- $761
- Updated
- 2024/03/01
- Product number
- F0372000
- Product name
- Formoterol fumarate dihydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- f0372000
- Price
- $153
- Updated
- 2024/03/01
Formoterol fumarate dihydrate Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
Formoterol is a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic.
Uses
ForMoterol FuMarate Dihydrate is a selective β2-adrenergic receptor agonist,it is used as an antiasthmatic.
Biological Activity
Potent, selective and long-acting β 2 -adrenoceptor agonist. Displays 330-fold selectivity for β 2 over β 1 receptors (pK d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD 2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.
Biochem/physiol Actions
β2-Adrenoreceptor agonist.
Drug interactions
The efficacy and tolerability of glycopyrronium/formoterol fumarate metered dose inhaler, a fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate 14.4/10 μg (equivalent to glycopyrrolate/formoterol fumarate 18/9.6 μg) delivered by metered dose inhaler using innovative co-suspension delivery technology, was investigated in patients (n = 292) with COPD [12C]. There were no meaningful pharmacokinetic interactions, whether drug–drug or due to formulation, between glycopyrronium and formoterol following treatment with formulated using a new co-suspension delivery technology. The incidence of cardiovascular events of special interest was low (stroke, 0%–0.4%; cardiac ischemia, 0.4%–2.3%; cardiac failure, 1.3%–2.5%; arrhythmia, 1.3%–3.2%), and no important trends in clinical laboratory results, vital signs, or electrocardiograms were observed[1].
References
[1] Aagaard, Lise . "A worldwide yearly survey of new data in adverse drug reactions." (2014).
Formoterol fumarate dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Formoterol fumarate dihydrate Suppliers
View Lastest Price from Formoterol fumarate dihydrate manufacturers
- Product
- Formoterol Fumarate Monohydrate/ dihydrate 183814-30-4
- Price
- US $0.00/g/Bag
- Min. Order
- 10g
- Purity
- 98.5%min; JP14
- Supply Ability
- 20kg/month
- Release date
- 2021-06-03
- Product
- Formoterol Fumarate Dihydrate 183814-30-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 TONS
- Release date
- 2022-11-07
- Product
- (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate dihydrate 183814-30-4
- Price
- US $65.00-650.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-20