ChemicalBook > CAS DataBase List > 2,5-Difluoronitrobenzene

2,5-Difluoronitrobenzene

Product Name
2,5-Difluoronitrobenzene
CAS No.
364-74-9
Chemical Name
2,5-Difluoronitrobenzene
Synonyms
1,4-DIFLUORO-2-NITROBENZENE;AKOS BBS-00006468;2,5-Difluoronitroben;3,5-diflurobenzalcohol;2,5-Difluotonitrobenzene;2,5-DIFLUORONITROBENZENE;1,4-difluoro-2-nitro-benzen;2,5-Difluoro-1-nitrobenzene;2,5-Difluoronitrobenzene98%;1-Nitro-2,5-difluorobenzene
CBNumber
CB0219938
Molecular Formula
C6H3F2NO2
Formula Weight
159.09
MOL File
364-74-9.mol
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2,5-Difluoronitrobenzene Property

Melting point:
-11.7 °C (lit.)
Boiling point:
206.5 °C (lit.)
Density 
1.467 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.509(lit.)
Flash point:
194 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
color 
Clear yellow
Specific Gravity
1.467
Water Solubility 
insoluble
BRN 
2210200
InChI
InChI=1S/C6H3F2NO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H
InChIKey
XNJAYQHWXYJBBD-UHFFFAOYSA-N
SMILES
C1(F)=CC=C(F)C=C1[N+]([O-])=O
CAS DataBase Reference
364-74-9(CAS DataBase Reference)
NIST Chemistry Reference
2,5-Difluoronitrobenzene(364-74-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
2810
WGK Germany 
3
RTECS 
CZ5715000
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29049090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
196622
Product name
2,5-Difluoronitrobenzene
Purity
97%
Packaging
25g
Price
$42.6
Updated
2025/07/31
TCI Chemical
Product number
D1700
Product name
2,5-Difluoronitrobenzene
Purity
>98.0%(GC)
Packaging
25g
Price
$141
Updated
2025/07/31
TRC
Product number
D447738
Product name
2,5-Difluoronitrobenzene
Packaging
500mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
075112
Product name
2,5-Difluoronitrobenzene
Purity
95+%
Packaging
10g
Price
$36
Updated
2021/12/16
Apolloscientific
Product number
PC2860
Product name
2,5-Difluoronitrobenzene
Purity
98%
Packaging
100g
Price
$40
Updated
2021/12/16
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2,5-Difluoronitrobenzene Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

2,5-Difluoronitrobenzene was used in the synthesis of :

  • N-alkylated 2-arylaminobenzimidazoles
  • quinoxalinones
  • N-(2-nitro-4-fluorophenyl)-l,2,3,4-tetrahydroisoquinoline

Synthesis

98-95-3

402-67-5

369-34-6

364-74-9

350-46-9

1493-27-2

GENERAL STEPS: In a FEP or PFA reactor fitted with a PTFE-lined magnetic stir bar and connected to a gas scrubber bottle, substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (2 mL per mL of C6H5R), and BF3-Et2O (1.3-1.5 mmol/mmol C6H5R) were added. The mixture was stirred at 0-5 °C (ice bath) for 10-15 min, followed by batchwise addition of XeF2 (1.2-1.3 mmol/mmol C6H5R). After each addition, the mixture was stirred at 22-25 °C for 3-5 min and recooled. After the addition was completed, the dark solution was continued to be stirred at 22-25 °C for 15-30 min. At the end of the reaction, the reaction was quenched by the addition of 10% aqueous KHCO3, the upper organic layer was separated and filtered through a short column packed with silica gel (40-60 μm) and subsequently dried with magnesium sulfate. The final products were analyzed by 19F NMR and GC/MS. The major products are listed in the table and the others are as follows (with GC/MS data).

References

[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8

2,5-Difluoronitrobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-Difluoronitrobenzene Suppliers

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View Lastest Price from 2,5-Difluoronitrobenzene manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2,5-Difluoronitrobenzene 364-74-9
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-08
Shaanxi Dideu Medichem Co. Ltd
Product
2,5-Difluoronitrobenzene 364-74-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20T
Release date
2024-06-11
Honest Joy Holdings Limited
Product
2,5-Difluoronitrobenzene 364-74-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.5%
Supply Ability
100 tons
Release date
2022-02-18

364-74-9, 2,5-DifluoronitrobenzeneRelated Search:

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