NORVERAPAMIL

Product Name: NORVERAPAMIL
CAS No.: 67018-85-3
Chemical Name: NORVERAPAMIL
Synonyms: D591;NORVERAPAMIL;Norverapamil D6;Verapamil Impurity J;Crufomate Impurity 3;Verapamil EP Impurity J Monomer;(2RS)-2-(3,4-Dimethoxy-phenyl)-5-[[;2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(3,4-dimethoxyphenethylamino)valeronitrile;5-[(3,4-dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-isopropylbenzeneacetonitrile
CBNumber: CB0223348
Molecular Formula: C26H36N2O4
Formula Weight: 440.58
MOL File: 67018-85-3.mol

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NORVERAPAMIL Property

Boiling point:: 586.1±50.0 °C(Predicted)
Density: 1.063±0.06 g/cm3(Predicted)
pka: 9.79±0.19(Predicted)
CAS DataBase Reference: 67018-85-3
EPA Substance Registry System: Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)- (67018-85-3)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0007901
Product name: NORVERAPAMIL
Purity: 95.00%
Packaging: 1MG
Price: $636.7
Updated: 2021/12/16

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NORVERAPAMIL Chemical Properties,Usage,Production

Chemical Properties

Yellowish to brownish oil

Uses

Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

Definition

ChEBI: 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile is a secondary amino compound that is 3,4-dimethoxyphenylethylamine in which one of the hydrogens attached to the nitrogen has been replaced by a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group. It is an aromatic ether, a nitrile, a polyether and a secondary amino compound.

in vivo

Norverapamil (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively^[4].

Animal Model:	Male Sprague-Dawley rats^[4]
Dosage:	9 mg/kg (Pharmacokinetic Study)
Administration:	Oral administration
Result:	t_1/2=9.4 hours; AUC=260 ng?h/mL; C_max=41.6 ng/mL.

IC 50

L-type calcium channel

References

[1] Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66. DOI:10.1093/infdis/jiu095
[2] Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. PMID:10773005
[3] Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302. DOI:10.1016/j.ejps.2013.07.012
[4] Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):163-8. DOI:10.1007/BF03191168

NORVERAPAMIL Preparation Products And Raw materials

Raw materials

Preparation Products

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NORVERAPAMIL Suppliers

China 20 Germany 2 India 3 United Kingdom 2 United States 13 Global 40

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Artis Chemistry (Shanghai) Co. Ltd.

Tel: 86-21-60936353
Fax: 86-21-60936352
Country: China
ProdList: 335
Advantage: 58

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@yongstandards.com
Country: China
ProdList: 10000
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
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CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
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sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
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Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
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Nanjing Shizhou Biology Technology Co.,Ltd

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Hubei Xinyang Medical Technology Co., Ltd

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cjbscvictory

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Beijing Jin Ming Biotechnology Co., Ltd.

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Email: psaitong@jm-bio.com
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Nanjing Shizhou Biology Technology Co.,Ltd

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TargetMol Chemicals Inc.

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Country: China
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Cato Research Chemicals Inc.

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Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

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Changzhou Xianglong Pharmaceutical Technology Co., Ltd.,

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Hubei Yangxin Medical Technology Co., Ltd.

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DAYANG CHEM (HANGZHOU) CO.,LTD

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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67018-85-3, NORVERAPAMILRelated Search:

(+/-)-Verapamil hydrochloride R(+)-VERAPAMIL HYDROCHLORIDE METHOXY-(-)-VERAPAMIL HYDROCHLORIDE (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile S(-)-VERAPAMIL NORVERAPAMIL HCL,(+-)-VERAPAMIL HYDROCHLORIDE, NOR-METHYL (NORVERAPAMIL HYDROCH,NORVERAPAMIL HYDROCHLORIDE Valeronitrile NORVERAPAMIL-D7 VERAPAMILETHYL METHANETHIOSULFONATE, BROMIDE NORVERAPAMIL METHOXYVERAPAMIL HYDROCHLORIDE (S)-(-)-Norverapamil Hydrochloride VERAPAMIL-D6, HYDROCHLORIDE (R)-(+)-Norverapamil Hydrochloride NORVERAPAMIL-D6, HYDROCHLORIDE NORVERAPAMIL-D7, HYDROCHLORIDE norgallopamil Norverapamil-d7 HCl

NORVERAPAMIL

Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)-ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-

D591

2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(3,4-dimethoxyphenethylamino)valeronitrile

α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-isopropylbenzeneacetonitrile

Verapamil Impurity J

Norverapamil D6

5-[(3,4-dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile

(2RS)-2-(3,4-Dimethoxy-phenyl)-5-[[

Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-

Verapamil EP Impurity J Monomer

Crufomate Impurity 3

67018-85-3

C26H36N2O4