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NORVERAPAMIL

Product Name
NORVERAPAMIL
CAS No.
67018-85-3
Chemical Name
NORVERAPAMIL
Synonyms
D591;NORVERAPAMIL;Norverapamil D6;Verapamil Impurity J;Crufomate Impurity 3;Verapamil EP Impurity J Monomer;(2RS)-2-(3,4-Dimethoxy-phenyl)-5-[[;2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(3,4-dimethoxyphenethylamino)valeronitrile;5-[(3,4-dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-isopropylbenzeneacetonitrile
CBNumber
CB0223348
Molecular Formula
C26H36N2O4
Formula Weight
440.58
MOL File
67018-85-3.mol
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NORVERAPAMIL Property

Boiling point:
586.1±50.0 °C(Predicted)
Density 
1.063±0.06 g/cm3(Predicted)
pka
9.79±0.19(Predicted)
CAS DataBase Reference
67018-85-3
EPA Substance Registry System
Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)- (67018-85-3)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0007901
Product name
NORVERAPAMIL
Purity
95.00%
Packaging
1MG
Price
$636.7
Updated
2021/12/16
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NORVERAPAMIL Chemical Properties,Usage,Production

Chemical Properties

Yellowish to brownish oil

Uses

Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

Definition

ChEBI: 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile is a secondary amino compound that is 3,4-dimethoxyphenylethylamine in which one of the hydrogens attached to the nitrogen has been replaced by a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group. It is an aromatic ether, a nitrile, a polyether and a secondary amino compound.

in vivo

Norverapamil (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively[4].

Animal Model:Male Sprague-Dawley rats[4]
Dosage:9 mg/kg (Pharmacokinetic Study)
Administration:Oral administration
Result:t1/2=9.4 hours; AUC=260 ng?h/mL; Cmax=41.6 ng/mL.

IC 50

L-type calcium channel

References

[1] Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66. DOI:10.1093/infdis/jiu095
[2] Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. PMID:10773005
[3] Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302. DOI:10.1016/j.ejps.2013.07.012
[4] Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):163-8. DOI:10.1007/BF03191168

NORVERAPAMIL Preparation Products And Raw materials

Raw materials

Preparation Products

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NORVERAPAMIL Suppliers

China 20 Germany 2 India 3 United Kingdom 2 United States 13 Global 40
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58

67018-85-3, NORVERAPAMILRelated Search:

(+/-)-Verapamil hydrochloride R(+)-VERAPAMIL HYDROCHLORIDE METHOXY-(-)-VERAPAMIL HYDROCHLORIDE (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile S(-)-VERAPAMIL NORVERAPAMIL HCL,(+-)-VERAPAMIL HYDROCHLORIDE, NOR-METHYL (NORVERAPAMIL HYDROCH,NORVERAPAMIL HYDROCHLORIDE Valeronitrile NORVERAPAMIL-D7 VERAPAMILETHYL METHANETHIOSULFONATE, BROMIDE NORVERAPAMIL METHOXYVERAPAMIL HYDROCHLORIDE (S)-(-)-Norverapamil Hydrochloride VERAPAMIL-D6, HYDROCHLORIDE (R)-(+)-Norverapamil Hydrochloride NORVERAPAMIL-D6, HYDROCHLORIDE NORVERAPAMIL-D7, HYDROCHLORIDE norgallopamil Norverapamil-d7 HCl

  • NORVERAPAMIL
  • Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)-ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-
  • D591
  • 2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(3,4-dimethoxyphenethylamino)valeronitrile
  • α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-isopropylbenzeneacetonitrile
  • Verapamil Impurity J
  • Norverapamil D6
  • 5-[(3,4-dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
  • (2RS)-2-(3,4-Dimethoxy-phenyl)-5-[[
  • Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-
  • Verapamil EP Impurity J Monomer
  • Crufomate Impurity 3
  • 67018-85-3
  • C26H36N2O4