(+/-) 14-HDOHE

Product Name: (+/-) 14-HDOHE
CAS No.: 87042-40-8
Chemical Name: (+/-) 14-HDOHE
Synonyms: (14-HDHA;(+/-) 14-HDOHE;14-HYDROXY DOCOSAHEXAENOIC ACID;(+/-)14-HYDROXY-4Z,7Z,10Z,12E,16Z,19Z-DOCOSAHEXAENOIC ACID;4,7,10,12,16,19-Docosahexaenoic acid, 14-hydroxy-, (4Z,7Z,10Z,12E,16Z,19Z)-
CBNumber: CB0230764
Molecular Formula: C22H32O3
Formula Weight: 344.48768
MOL File: 87042-40-8.mol

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(+/-) 14-HDOHE Property

Boiling point:: 510.0±50.0 °C(Predicted)
Density: 0.995±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka: 4.58±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 33550
Product name: (±)14-HDHA
Packaging: .025mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 33550
Product name: (±)14-HDHA
Packaging: .05mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 33550
Product name: (±)14-HDHA
Packaging: .1mg
Price: $273
Updated: 2024/03/01

Cayman Chemical

Product number: 33550
Product name: (±)14-HDHA
Packaging: .25mg
Price: $602
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: LIP0000630
Product name: (+/-)14-HYDROXY-4Z,7Z,10Z,12E,16Z,19Z-DOCOSAHEXAENOIC ACID
Purity: 95.00%
Packaging: 50μG
Price: $452.1
Updated: 2021/12/16

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(+/-) 14-HDOHE Chemical Properties,Usage,Production

Description

(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.^1,2 It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.^3,4,5 DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA.^6,7,5 14(S)-HDoHE is also produced by salmon gills upon stimulation with calcium ionophore.⁸ 14(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC₅₀ values of about 70, 3.6, and 5.3 μM, respectively.^7,9 (±)14-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

Definition

ChEBI: 14-HDoHE is a hydroxydocosahexaenoic acid that consists of (4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoic acid bearing an additional 14-hydroxy substituent. It has a role as a human xenobiotic metabolite. It is a hydroxydocosahexaenoic acid and a secondary allylic alcohol. It is a conjugate acid of a 14-HDoHE(1-).

References

1. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate J. Lipid Res. 25(5),507-517(1984).
2. Reynaud, D., Thickitt, C.P., and Pace-Asciak, C.R. Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by α-tocopherol-directed autoxidation Anal. Biochem. 214(1),165-170(1993).
3. VanRollins, M., Baker, R.C., Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes J. Biol. Chem. 259(9),5776-5783(1984).
4. Yamane, M., Abe, A., and Yamane, S. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate J. Chromatogr. 652(2),123-136(1994).
5. Kim, H.Y., Karanian, J.W., Shingu, T., et al. Sterochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate Prostaglandins 40(5),473-490(1990).
6. Avelda?o, M.I., and Sprecher, H. Synthesis of hydroxy fatty acids from 4,7,10,13,16,19-[1-¹⁴C] docosahexaenoic acid by human platelets J. Biol. Chem. 258(15),9339-9343(1983).
7. Lagarde, M., Croset, M., Guichardant, M., et al. Role of lipoxygenase products in platelet function: Relation to fatty acid modified phospholipids Adv. Exp. Med. Biol. 192,327-335(1985).
8. Bell, J.G., Dick, J.R., and Sargent, J.R. Effect of diets rich in linoleic or α-linoleic acid on phospholipid fatty acid composition and eicosanoid production in Atlantic Salmon (Salmo salar) Lipids 28,819-826(1993).
9. Karanian, J.W., Kim, H.Y., and Salem, N., Jr. Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619)-induced smooth muscle contraction J. Pharmacol. Exp. Ther. 270(3),1105-1109(1994).

(+/-) 14-HDOHE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-) 14-HDOHE Suppliers

China 8 Switzerland 1 United States 4 Global 13

Yichang Zhongyitai Trading Co., Ltd.

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Alfa Chemistry

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

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Alfa Chemistry

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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TargetMol Chemicals Inc.

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Shanghai Maclean Biochemical Technology Co., LTD

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Shanghai Yifei Biotechnology Co. , Ltd.

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87042-40-8, (+/-) 14-HDOHERelated Search:

METHYL ISOCYANOACETATE PHENYLSELENOL SALCOMINE Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE COBALT(II) ACETYLACETONATE TERT-BUTYL ISOCYANIDE Cupric acetylacetonate Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ferric acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE Ethyl isocyanoacetate Aluminum acetylacetonate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE

(+/-) 14-HDOHE

14-HYDROXY DOCOSAHEXAENOIC ACID

(+/-)14-HYDROXY-4Z,7Z,10Z,12E,16Z,19Z-DOCOSAHEXAENOIC ACID

(14-HDHA

4,7,10,12,16,19-Docosahexaenoic acid, 14-hydroxy-, (4Z,7Z,10Z,12E,16Z,19Z)-

87042-40-8