ChemicalBook > CAS DataBase List > 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene

Product Name: 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
CAS No.: 1103738-29-9
Chemical Name: 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Synonyms: 1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene;Ipragliflozin intermediate 2;Benzene, 1-chloro-2-[(4-ethoxyphenyl)Methyl]-4-iodo-;SOTA-006;EOS-61384;EGT-OET(I);Dapagliflozin Impurity 78;Tricosanoic Acid Impurity 7;S-lodo-Z-chloro-^-ethoxydiphenylmethane;5-Iodo-2-chloro-4’-ethoxydiphenylmethane
CBNumber: CB02504720
Molecular Formula: C15H14ClIO
Formula Weight: 372.63
MOL File: 1103738-29-9.mol

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1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene Property

Melting point:: 62 – 64°C
Boiling point:: 411.2±40.0 °C(Predicted)
Density: 1.531±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Pale Yellow
InChI: InChI=1S/C15H14ClIO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(17)5-8-15(12)16/h3-8,10H,2,9H2,1H3
InChIKey: CZFRIPGHKLGMEU-UHFFFAOYSA-N
SMILES: C1(Cl)=CC=C(I)C=C1CC1=CC=C(OCC)C=C1
CAS DataBase Reference: 1103738-29-9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C368090
Product name: 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Packaging: 25g
Price: $385
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0362265
Product name: 1-CHLORO-2-(4-ETHOXYBENZYL)-4-IODOBENZENE
Purity: 95.00%
Packaging: 5MG
Price: $503.68
Updated: 2021/12/16

Matrix Scientific

Product number: 100559
Product name: 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

Matrix Scientific

Product number: 100559
Product name: 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

Ark Pharm

Product number: AK120832
Product name: 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Purity: 98%
Packaging: 5g
Price: $36
Updated: 2021/12/16

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1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene Chemical Properties,Usage,Production

Uses

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene is used in the synthesis of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.

Synthesis

1103738-26-6

1103738-29-9

Under nitrogen protection, 1 g of (2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone and 10.88 g of dichloromethane were added to a 100 mL reaction flask and heated to 30-40 °C. Subsequently 2.88 g of acetonitrile and 0.2 g of sodium borohydride were added and the reaction was stirred at 30-40 °C for 0.5 hours. Slowly 0.84 g of trimethylchlorosilane was added dropwise and the temperature was maintained at 30-40 °C for 4 hours of reaction. After that, 0.6 g of sodium borohydride and 2.52 g of trimethylchlorosilane were added and the reaction was continued at 30-40°C for 4 hours. The reaction solution was cooled to 0-5 °C, 2.2 g of boron trifluoride diethyl ether was added slowly dropwise, the temperature was controlled to be lower than 10 °C, and then the temperature was raised to 30-35 °C and maintained for 4 hours. Cooled again to 10-15 °C, added 0.6 g of sodium borohydride and 1.65 g of boron trifluoride diethyl ether, and heated to 30-35 °C for 4 hours. After the reaction was completed, cooled to 0-5 °C, 20 mL of dichloromethane was added, 20 mL of 12% sodium carbonate solution was added slowly dropwise, and stirring was continued for 20 minutes after the drop. The liquid was separated and the aqueous phase was extracted twice with 40 mL of dichloromethane. The organic phases were combined, washed with water once, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain a light yellow oily crude product. The crude product was dissolved in 3mL of toluene, heated to 60°C, slowly added 12mL of methanol dropwise, cooled to -10°C and crystallized for 8 hours. Filtering, drying, to get 0.85g white solid product, yield 86%.

References

[1] Patent: US2009/30198, 2009, A1. Location in patent: Page/Page column 9
[2] Patent: US2010/16422, 2010, A1. Location in patent: Page/Page column 5-6
[3] Patent: CN106316803, 2017, A. Location in patent: Paragraph 0018
[4] Patent: EP2332947, 2011, A1. Location in patent: Page/Page column 7-8
[5] Patent: EP2661256, 2018, B1. Location in patent: Paragraph 0096

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 1103738-29-9
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-15

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 1103738-29-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-09

Hebei Dangtong Import and export Co LTD

Product: 4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene 1103738-29-9
Price: US $300.00-260.00/kg
Min. Order: 100kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-06

1103738-29-9, 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzeneRelated Search:

Benzyl chloride Dapagliflozin 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Empagliflozin Canagliflozin heMihydrate 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone PF-04971729 Ipragliflozin Canagliflozin 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE Crizotinib 5-bromo-2-chloro-4’-ethoxydiphenylmethane (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone

Benzene, 1-chloro-2-[(4-ethoxyphenyl)Methyl]-4-iodo-

4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene

1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene

1-Chloro-2-[(4-ethoxyphenyl)Methyl]-4-iodobenzene

1-CHLORO-2(4-ETHOXYPHENYYL)METHYL-4-IODOBENZENE

1-(2-Chloro-5-iodobenzyl)-4-ethoxybenzene

SOTA-006

EGT-OET(I)

EOS-61384

Ipragliflozin intermediate 2

4-（5-LODO-2-CHLOROBENZYL）PHENYL ETHYL ETHER

4-(5-Iodo-2-chlorobenzyl)phenyl Ethyl Ether

Dapagliflozin Impurity 78

1-Chloro-4-iodo-2-(4-ethoxybenzyl)benzene

S-lodo-Z-chloro-^-ethoxydiphenylmethane

5-Iodo-2-chloro-4’-ethoxydiphenylmethane

5-lodo-2-chIoro-4’-ethoxydiphenyImethane

2-(4-ethoxybenzyl)-4-iodo-1-chloro benzene

Tricosanoic Acid Impurity 7

1103738-29-9

C15H14ClIO

1103738-29-9