ChemicalBook > CAS DataBase List > 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene

Product Name
1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
CAS No.
1103738-29-9
Chemical Name
1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Synonyms
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene;Ipragliflozin intermediate 2;Benzene, 1-chloro-2-[(4-ethoxyphenyl)Methyl]-4-iodo-;SOTA-006;EOS-61384;EGT-OET(I);Dapagliflozin Impurity 78;Tricosanoic Acid Impurity 7;S-lodo-Z-chloro-^-ethoxydiphenylmethane;5-Iodo-2-chloro-4’-ethoxydiphenylmethane
CBNumber
CB02504720
Molecular Formula
C15H14ClIO
Formula Weight
372.63
MOL File
1103738-29-9.mol
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1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene Property

Melting point:
62 – 64°C
Boiling point:
411.2±40.0 °C(Predicted)
Density 
1.531±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Pale Yellow
InChI
InChI=1S/C15H14ClIO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(17)5-8-15(12)16/h3-8,10H,2,9H2,1H3
InChIKey
CZFRIPGHKLGMEU-UHFFFAOYSA-N
SMILES
C1(Cl)=CC=C(I)C=C1CC1=CC=C(OCC)C=C1
CAS DataBase Reference
1103738-29-9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368090
Product name
1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Packaging
25g
Price
$385
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0362265
Product name
1-CHLORO-2-(4-ETHOXYBENZYL)-4-IODOBENZENE
Purity
95.00%
Packaging
5MG
Price
$503.68
Updated
2021/12/16
Matrix Scientific
Product number
100559
Product name
1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
Matrix Scientific
Product number
100559
Product name
1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
Ark Pharm
Product number
AK120832
Product name
1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Purity
98%
Packaging
5g
Price
$36
Updated
2021/12/16
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1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene Chemical Properties,Usage,Production

Uses

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene is used in the synthesis of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.

Synthesis

1103738-26-6

1103738-29-9

Under nitrogen protection, 1 g of (2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone and 10.88 g of dichloromethane were added to a 100 mL reaction flask and heated to 30-40 °C. Subsequently 2.88 g of acetonitrile and 0.2 g of sodium borohydride were added and the reaction was stirred at 30-40 °C for 0.5 hours. Slowly 0.84 g of trimethylchlorosilane was added dropwise and the temperature was maintained at 30-40 °C for 4 hours of reaction. After that, 0.6 g of sodium borohydride and 2.52 g of trimethylchlorosilane were added and the reaction was continued at 30-40°C for 4 hours. The reaction solution was cooled to 0-5 °C, 2.2 g of boron trifluoride diethyl ether was added slowly dropwise, the temperature was controlled to be lower than 10 °C, and then the temperature was raised to 30-35 °C and maintained for 4 hours. Cooled again to 10-15 °C, added 0.6 g of sodium borohydride and 1.65 g of boron trifluoride diethyl ether, and heated to 30-35 °C for 4 hours. After the reaction was completed, cooled to 0-5 °C, 20 mL of dichloromethane was added, 20 mL of 12% sodium carbonate solution was added slowly dropwise, and stirring was continued for 20 minutes after the drop. The liquid was separated and the aqueous phase was extracted twice with 40 mL of dichloromethane. The organic phases were combined, washed with water once, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain a light yellow oily crude product. The crude product was dissolved in 3mL of toluene, heated to 60°C, slowly added 12mL of methanol dropwise, cooled to -10°C and crystallized for 8 hours. Filtering, drying, to get 0.85g white solid product, yield 86%.

References

[1] Patent: US2009/30198, 2009, A1. Location in patent: Page/Page column 9
[2] Patent: US2010/16422, 2010, A1. Location in patent: Page/Page column 5-6
[3] Patent: CN106316803, 2017, A. Location in patent: Paragraph 0018
[4] Patent: EP2332947, 2011, A1. Location in patent: Page/Page column 7-8
[5] Patent: EP2661256, 2018, B1. Location in patent: Paragraph 0096

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene Suppliers

China 268 India 16 United States 5 Global 289
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Pharmaffiliates Analytics and Synthetics P. Ltd
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A.J Chemicals
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Stereokem, Inc.
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View Lastest Price from 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 1103738-29-9
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-15
Hebei Zhuanglai Chemical Trading Co Ltd
Product
1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 1103738-29-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-09
Hebei Dangtong Import and export Co LTD
Product
4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene 1103738-29-9
Price
US $300.00-260.00/kg
Min. Order
100kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-06

1103738-29-9, 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzeneRelated Search:

Benzyl chloride Dapagliflozin 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Empagliflozin Canagliflozin heMihydrate 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone PF-04971729 Ipragliflozin Canagliflozin 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE Crizotinib 5-bromo-2-chloro-4’-ethoxydiphenylmethane (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone

  • Benzene, 1-chloro-2-[(4-ethoxyphenyl)Methyl]-4-iodo-
  • 4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene
  • 1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
  • 1-Chloro-2-[(4-ethoxyphenyl)Methyl]-4-iodobenzene
  • 1-CHLORO-2(4-ETHOXYPHENYYL)METHYL-4-IODOBENZENE
  • 1-(2-Chloro-5-iodobenzyl)-4-ethoxybenzene
  • SOTA-006
  • EGT-OET(I)
  • EOS-61384
  • Ipragliflozin intermediate 2
  • 4-（5-LODO-2-CHLOROBENZYL）PHENYL ETHYL ETHER
  • 4-(5-Iodo-2-chlorobenzyl)phenyl Ethyl Ether
  • Dapagliflozin Impurity 78
  • 1-Chloro-4-iodo-2-(4-ethoxybenzyl)benzene
  • S-lodo-Z-chloro-^-ethoxydiphenylmethane
  • 5-Iodo-2-chloro-4’-ethoxydiphenylmethane
  • 5-lodo-2-chIoro-4’-ethoxydiphenyImethane
  • 2-(4-ethoxybenzyl)-4-iodo-1-chloro benzene
  • Tricosanoic Acid Impurity 7
  • 1103738-29-9
  • C15H14ClIO
  • 1103738-29-9