ChemicalBook > CAS DataBase List > VU-29

VU-29

Product Name: VU-29
CAS No.: 890764-36-0
Chemical Name: VU-29
Synonyms: VU-29;VU-29/VU29;VU-29 ，S1970;VU-29, 10 mM in DMSO;N-(1,3-Diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide;N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide;BenzaMide, N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitro-;mGluR,hippocampal,inhibit,rat,LTP,VU29,potentiator,VU-29,allosteric,Metabotropic glutamate receptors,Inhibitor,LTD
CBNumber: CB02526230
Molecular Formula: C22H16N4O3
Formula Weight: 384.39
MOL File: 890764-36-0.mol

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VU-29 Property

Melting point:: 221-223℃
Boiling point:: 545.0±45.0 °C(Predicted)
Density: 1.30
storage temp.: Store at RT
solubility: Soluble to 100 mM in DMSO
form: Powder
pka: 11.17±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4458
Product name: VU29
Purity: ≥99%(HPLC)
Packaging: 10
Price: $199
Updated: 2021/12/16

Tocris

Product number: 4458
Product name: VU29
Purity: ≥99%(HPLC)
Packaging: 50
Price: $738
Updated: 2021/12/16

Usbiological

Product number: 257073
Product name: VU 29
Packaging: 10mg
Price: $466
Updated: 2021/12/16

TRC

Product number: D678873
Product name: DPAP
Packaging: 2.5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0028668
Product name: VU-29
Purity: 98.04%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

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VU-29 Chemical Properties,Usage,Production

Uses

DPAP is a potent, postive allosteric, potentiator at mGluR-5.

in vivo

VU-29 (500 nM) potentiates DHPG induced increases in phosphoinositide (PI) hydrolysis in rat hippocampal slices. VU-29 potentiates threshold TBS-induced long term potentiation (LTP) in rat hippocampal CA1 region. VU-29 (1 μM) potentiates chemically induced mGluR-long term depression (LTD) in area CA1 of the rat hippocampus. VU-29 (1 μM) potentiates stimulus-induced NMDA receptor-independent LTD^[1].

IC 50

rat mGluR5: 9 nM (EC₅₀); rat mGluR1: 557 nM (EC₅₀); rat mGluR2: 1.5 μM (EC₅₀); hmGluR4: 154 nM (EC₅₀); rat mGluR5: 224 nM (Ki)

VU-29 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU-29 Suppliers

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890764-36-0, VU-29Related Search:

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU0134992(hydrochloride) VU6005649 VU 591 hydrochloride VU0810464 VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 6008667 (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121 VU 0360223 VU 0364439 VU0650786

VU-29

BenzaMide, N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitro-

N-(1,3-Diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide

N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide

mGluR,hippocampal,inhibit,rat,LTP,VU29,potentiator,VU-29,allosteric,Metabotropic glutamate receptors,Inhibitor,LTD

VU-29/VU29

VU-29, 10 mM in DMSO

VU-29 ，S1970

890764-36-0