N3-PEG6-tBu
- Product Name
- N3-PEG6-tBu
- CAS No.
- 406213-76-1
- Chemical Name
- N3-PEG6-tBu
- Synonyms
- N3-PEG6-tBu;Azido-PEG6-C2-Boc;Azido-PEG6-COOtBu;Azido-PEG6-tBu Ester;N3-PEG6-CH2CH2COOtBu;Azido-PEG6-CH2CH2COOtBu;Azido-PEG7-t-butyl ester;Azido-PEG7-t-butly ester;N3-PEG6-CH2CH2COOt<;tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate
- CBNumber
- CB02546988
- Molecular Formula
- C19H37N3O8
- Formula Weight
- 435.51238
- MOL File
- 406213-76-1.mol
N3-PEG6-tBu Property
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C19H37N3O8/c1-19(2,3)30-18(23)4-6-24-8-10-26-12-14-28-16-17-29-15-13-27-11-9-25-7-5-21-22-20/h4-17H2,1-3H3
- InChIKey
- HRNUWAOLFSWRDG-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AS103950
- Product name
- N3-PEG6-CH2CH2COOtBu
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $322
- Updated
- 2021/12/16
- Product number
- BP-20507
- Product name
- Azido-PEG6-t-butylester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- 280703
- Product name
- N3-PEG6-tBu
- Packaging
- 1g
- Price
- $610
- Updated
- 2021/12/16
- Product number
- AS103950
- Product name
- N3-PEG6-CH2CH2COOtBu
- Purity
- 95+%
- Packaging
- 1g
- Price
- $634
- Updated
- 2021/12/16
- Product number
- 280703
- Product name
- N3-PEG6-tBu
- Packaging
- 5g
- Price
- $1583
- Updated
- 2021/12/16
N3-PEG6-tBu Chemical Properties,Usage,Production
Description
Azido-PEG6-t-butyl ester is a PEG molecule consisting of an azide group and a t-butyl ester moiety. he azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG5 spacer increases solubility in aqueous media.
Uses
Azido-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-C2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N3-PEG6-tBu Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N3-PEG6-tBu manufacturers
- Product
- azido-PEG6-t-Butyl ester 406213-76-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23