ChemicalBook > CAS DataBase List > 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

Product Name
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
CAS No.
314771-88-5
Chemical Name
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
Synonyms
Afatinib intermediate C;7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)a...;N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl];N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-;N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-;N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine;7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)aMino-6-nitroquinazoline;(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-aMine;7-((S)-tetrahydrofuran-3-yloxy) -N-(3-chloro-4-fluorophenyl) -6-nitroquinazolin-4-amine;N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinaMine
CBNumber
CB02602866
Molecular Formula
C18H14ClFN4O4
Formula Weight
404.78
MOL File
314771-88-5.mol
More
Less

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- Property

Boiling point:
585.0±50.0 °C(Predicted)
Density 
1.534±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
5.07±0.70(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
C367720
Product name
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Packaging
1g
Price
$215
Updated
2021/12/16
TRC
Product number
C367720
Product name
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Packaging
10g
Price
$635
Updated
2021/12/16
TRC
Product number
C367720
Product name
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Packaging
25g
Price
$1075
Updated
2021/12/16
AK Scientific
Product number
3302AH
Product name
4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
Packaging
25g
Price
$1113
Updated
2021/12/16
ChemScene
Product number
CS-M0992
Product name
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Packaging
25g
Price
$732
Updated
2021/12/16
More
Less

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- Chemical Properties,Usage,Production

Uses

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- Suppliers

China 159 India 6 United Kingdom 1 United States 3 Global 169
Arizest(Shanghai)Pharmatech Co.,Ltd
Tel
60753300-53010 13671599112
Email
geshi.zhuang@acebright.com
Country
China
ProdList
97
Advantage
58
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Feibo Chemical Technology Co., Ltd
Tel
021-58955608,2250286 15921236618
Email
blinkzeng@gmail.com
Country
China
ProdList
522
Advantage
62
Synches Co., Ltd.
Tel
021-53292253
Fax
021-53292253
Email
biz@synches.com
Country
China
ProdList
199
Advantage
64
Jinan Bond Chemical Technology Co., Ltd.
Tel
86-531-88280989
Fax
86-531-88280989
Email
mymail1996@126.com
Country
China
ProdList
256
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9458
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
ShangHai YingYi Chemical Technology Co., Ltd.
Tel
86-21-50700185 13764109623
Fax
86-21-50700185
Email
sale@inyelchem.com
Country
China
ProdList
178
Advantage
55
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
DONGSHENG CHIRAL PHARMA
Tel
18051538752
Email
3755454181@qq.com
Country
China
ProdList
435
Advantage
55
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-18601685-898 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2783
Advantage
60
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Jinan XuanDe Chemical Co., Ltd.
Tel
0531-88803958; 18866891188
Fax
0531-82777287
Email
zhaojiangxia@shiningpharm.com
Country
China
ProdList
276
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10274
Advantage
55
Nanjing YiFan Biological Technology Co., Ltd.
Tel
025-025-52700520 18914499889
Fax
025-52700520
Email
sales@yfbiotech.com
Country
China
ProdList
494
Advantage
58
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Tianjing Geneston Bio-tech Co.,Ltd.
Tel
022-60131465 18920720807
Fax
022-58558581
Email
zishan_1986@163.com
Country
China
ProdList
743
Advantage
58
Haiyan Difu Chemical Co., Ltd.
Tel
0573-86186729 15957397789
Fax
0573-86722262
Country
China
ProdList
71
Advantage
60
ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD
Tel
0571-87322520 18957127338
Fax
QQ:3007632051
Email
sales@zetchem.com
Country
China
ProdList
480
Advantage
55
Intelligence Pharm Science(Shanghai) Co., Ltd.
Tel
021-57898186
Fax
021-37699262
Country
China
ProdList
449
Advantage
55
Anqing CHICO Pharmaceutical Co., Ltd.
Tel
13585175604
Fax
+86-25-52261140
Email
sales@chicopharm.com
Country
China
ProdList
453
Advantage
65
Nanjing Chempioneer Pharmaceutical Co., Ltd.
Tel
18068075658
Fax
-
Email
sales@chempioneer.com
Country
China
ProdList
1811
Advantage
58
Wu han Spring Pharmaceutical Technology Co.,Ltd
Tel
027-87689766 13797071802
Fax
QQ:2042849844
Email
sales@sprchem.com
Country
China
ProdList
56
Advantage
55
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Yangzhou QinYuan Pharmaceutical Co., Ltd.
Tel
0514-80939770 13773367191
Fax
0514-82664689
Email
yzqyyykj@163.com
Country
China
ProdList
242
Advantage
55
Shanghai Rochi Pharmaceutical Co., Ltd.
Tel
021-38751876 15000076078
Fax
021-50275764
Email
Info@rochipharma.com
Country
China
ProdList
568
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Hunan Hezhong Pharmaceutical Co., Ltd.
Tel
027-87614241 3310618156
Fax
-
Email
3310618156@qq.com
Country
China
ProdList
62
Advantage
50
Jinan SanZhi Pharmaceutical Technology Co., Ltd.
Tel
15053191807
Fax
-
Email
sales_sanzhi@163.com
Country
China
ProdList
286
Advantage
55
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
BePharm Ltd
Tel
400-685-9117
Fax
021-51816740
Email
market@bepharm.com
Country
China
ProdList
15081
Advantage
60
Tonichem Pharmaceutical Technology Co., Ltd.
Tel
+86 (0752) 222-7171, +86 15815821171
Fax
+86 (0752) 222-6171
Country
China
ProdList
1120
Advantage
58
Sichuan Lanli Pharmaceutical Co., Ltd.
Tel
028-61186658 15881182642
Fax
028-61186658
Email
2377807226@qq.com
Country
China
ProdList
40
Advantage
58
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Roark Standards
Tel
0755-83552066 15986688328
Fax
0755-83552066
Email
service@roarkstandards.com
Country
China
ProdList
1442
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
ProdList
7181
Advantage
55
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-50664929, 13971561712
Fax
027-50664927 / QQ: 3452835437
Email
hubxys2001@163.com
Country
China
ProdList
1437
Advantage
55
BIO-PHARMACY (Wuhan) Co., Ltd.
Tel
0711-5919292 15307133740
Fax
0711-5919292
Email
3451683016@qq.com
Country
China
ProdList
1069
Advantage
58
Shanghai Elestone Pharmaceutical Technology Co., Ltd.
Tel
021-36680027/1762825045
Email
sales2@elestone.com.cn
Country
China
ProdList
296
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25004
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Shanghai Bojing Chemical Co., Ltd
Tel
021-37199966 13681836088
Fax
021-37597788
Email
bj@bj-chem.com
Country
China
ProdList
463
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4877
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4397
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
10056
Advantage
58
More
Less

View Lastest Price from 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- 314771-88-5
Price
US $1365.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-06-22
Nanjing Fred Technology Co., Ltd
Product
N-(3-chloro-4-fluorophenyl)-6-nitro-7-(((3s)-tetrahydro-3-furanyl)oxy)-4-quinazolinamine 314771-88-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
Henan Aochuang Chemical Co.,Ltd.
Product
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy] 314771-88-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

314771-88-5, 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-Related Search:

4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide Losartan potassium Afatinib Dimaleate impurity Alfatinib maleate trans-4-Dimethylaminocrotonic acid hydrochloride (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Afatinib 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Afatinib dimaleate (S)-(+)-3-Hydroxytetrahydrofuran Afatinib (BIBW 2992) 7-Fluoro-6-nitro-4-hydroxyquinazoline

  • 7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)aMino-6-nitroquinazoline
  • N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinaMine
  • Afatinib intermediate C
  • 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
  • (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-aMine
  • N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-
  • N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]
  • N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine
  • N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
  • 7-((S)-tetrahydrofuran-3-yloxy) -N-(3-chloro-4-fluorophenyl) -6-nitroquinazolin-4-amine
  • 7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)a...
  • (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine(AfatinibImpurity)
  • 314771-88-5
  • C18H14ClFN4O4
  • Afatinib Dimaleate