ChemicalBook > CAS DataBase List > tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate

Product Name
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
CAS No.
365998-36-3
Chemical Name
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
Synonyms
CarbaMic acid, N-[(1R,2S,5S)-2-aMino-5-[(diMethylaMino)carbonyl]cyclohexyl]-, 1,1-diMethylethyl ester;Edoxaban INTERMEDIATES Ⅰ;tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate;(1S,2R,4S)-N2-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine;D-1315;(5H-Pyrrolo[3;Edoxaban Impurity 47;Paracetamol Impurity 27;InterMediate of Edoxaban;Edoxaban INTERMEDIATES Ⅲ
CBNumber
CB02652836
Molecular Formula
C14H27N3O3
Formula Weight
285.38
MOL File
365998-36-3.mol
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tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Property

Boiling point:
434.4±45.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
Solid
pka
11.90±0.60(Predicted)
Appearance
White to off-white Solid
optical activity
-38.5°(C=0.01g/mL, MEOH, 20°C, 589nm)
InChI
InChI=1S/C14H27N3O3/c1-14(2,3)20-13(19)16-11-8-9(6-7-10(11)15)12(18)17(4)5/h9-11H,6-8,15H2,1-5H3,(H,16,19)/t9-,10-,11+/m0/s1
InChIKey
JCHIBKSSZNWERE-GARJFASQSA-N
SMILES
C(OC(C)(C)C)(=O)N[C@@H]1C[C@@H](C(N(C)C)=O)CC[C@@H]1N
CAS DataBase Reference
365998-36-3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B809495
Product name
tert-Butyl[(1R,2S,5S)-2-Amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate
Packaging
1g
Price
$250
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0065742
Product name
TERT-BUTYL N-[(1R,2S,5S)-2-AMINO-5-(DIMETHYLCARBAMOYL)CYCLOHEXYL]CARBAMATE
Purity
95.00%
Packaging
5MG
Price
$458.62
Updated
2021/12/16
SynQuest Laboratories
Product number
4256-1-70
Product name
tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate
Purity
97.0%
Packaging
1g
Price
$490
Updated
2021/12/16
SynQuest Laboratories
Product number
4256-1-70
Product name
tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate
Purity
97.0%
Packaging
5G
Price
$790
Updated
2021/12/16
SynQuest Laboratories
Product number
4256-1-70
Product name
tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate
Purity
97.0%
Packaging
250mg
Price
$190
Updated
2021/12/16
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tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Chemical Properties,Usage,Production

Description

Tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate is a pharmaceutical intermediate compound used in the preparation of Edoxaban. Edoxaban is an oral anticoagulant drug used for the treatment of strokes due to blood clots, thrombosis, heart disease and cirrhosis of the liver.

Uses

Tert-butyl(1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate is an organic synthesis intermediates and pharmaceutical intermediates, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. It is a reagent used in the synthesis of cis-1,2-diaminocyclohexane derivative. It is also mainly used as raw material to synthesize reversible factor Xa inhibitor drug edoxaban[1]. The drug has been approved by the U.S. Food and Drug Administration as a direct oral anticoagulant and is the fourth direct oral anticoagulant approved for clinical use[2-3].

Referance：[1] Frantisek Nehaj, Juraj Sokol, Jela Ivankova, Michal Mokan, Marian Mokan, Jan Stasko, Edoxaban affects TRAP-dependent platelet aggregation, Journal of Thrombosis and Thrombolysis, 2020, 49, 578-583.
[2] Juraj Sokol, Frantisek Nehaj, Jela Ivankova, Michal Mokan, Lenka Lisa, Jana Zolkova, Lubica Vadelova, Marian Mokan, Jan Stasko, Impact of Edoxaban on Thrombin-Dependent Platelet Aggregation,Clinical and Applied Thrombosis/Hemostasis, 2020.
[3] Mara Poulakos, Jacqueline N Walker, Umima Baig, Tosin David, Edoxaban: A direct oral anticoagulant, American Journal of Health-System Pharmacy, 2017,74, 117–129.

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Suppliers

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View Lastest Price from tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD
Product
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate 365998-36-3
Price
US $0.00-0.00/KG
Min. Order
0.001KG
Purity
99.99%
Supply Ability
200000T
Release date
2025-06-16
Wuhan Biocar Pharmacy CO.,Ltd.
Product
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate 365998-36-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
600kg
Release date
2025-03-11
Anhui Ruihan Technology Co., Ltd
Product
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate 365998-36-3
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-09-08

365998-36-3, tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMateRelated Search:

Rivaroxaban Donepezil Edoxaban (TsOH salt) edoxaban 2-Amino-5-chloropyridine Edoxaban Impurity 8 N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester Oxalic acid 1-ethyl ester 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate Acetic acid, [(5-chloro-2-pyridinyl)aMino]oxo- 480450-71-3 Edoxaban Impurity 37 Edoxaban Impurity 12 (1R,2R,4S) 2-Amino-3-chloropyridine

  • (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester
  • CarbaMic acid, N-[(1R,2S,5S)-2-aMino-5-[(diMethylaMino)carbonyl]cyclohexyl]-, 1,1-diMethylethyl ester
  • Edoxaban INTERMEDIATES Ⅰ
  • Edoxaban INTERMEDIATES Ⅱ
  • Edoxaban INTERMEDIATES Ⅲ
  • InterMediate of Edoxaban
  • tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate
  • Tert-Butyl [(1R,2S,5S)-2-aMino-5-[(diMethylaMino)carbonyl]cyclohexyl]carbaMate(for Edoxaban)
  • (1S,2R,4S)-N2-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine
  • Carbamic acid, N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl este
  • Carbamic acid, N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester, ethanedioate (1:1)
  • N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl] -, 1,1-dimethylethyl ester
  • D-1315
  • (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]c
  • N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamic acid 1,1-dimethylethyl ester
  • (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl esterChemicalBook
  • (5H-Pyrrolo[3
  • 4-d]thiazole-5-carboxylic acid
  • 5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4
  • Carbamic acid,[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-,1,1-dimethylethyl ester
  • [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate
  • ert-butylN-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate
  • (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl este
  • Edoxaban Impurity 47
  • Carbamic acid,[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl...
  • (1R,2S,5S)-2-amino-5-[(dimethylamino) carbonyl]cyclohexyl]-,1,1-dimethylethy l ester
  • tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate ethanedioate
  • tert-butyl (1R,2S,5S)-5-(dimethylcarbamoyl)-2-aminocyclohexylcarbamate
  • Edoxaban Impurity 29 Monomer
  • tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
  • Edoxaban Impurity 30 (1R,2S,5S)
  • Paracetamol Impurity 27
  • tert-butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate (Intermediate of Edoxaban mesylate)
  • Ethyl-3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5- carboxamido)propanoate (Intermediate of Dabigatran etexilate mesylate)
  • 365998-36-3
  • 1243308-37-7