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Methyl 2-bromo-3-methylbenzoate

Product Name
Methyl 2-bromo-3-methylbenzoate
CAS No.
131001-86-0
Chemical Name
Methyl 2-bromo-3-methylbenzoate
Synonyms
Methyl 2-bromo-3-met;Methyl 2-Bromo-m-toluate;METHYL 2-BROMO-3-METHYLBENZOATE;Methyl 3-Methyl-2-Bromobenzoate;2-Bromo-m-toluic acid methyl ester;Methyl2-bromo-3-methylbenzoate,98%;Methyl 2-Bromo-3-Methoxynicotinate;2-BROMO-3-METHYL-BENZOIC ACID METHYL ESTER;Benzoic acid, 2-bromo-3-methyl-, methyl ester;2-Bromo-m-toluic acid methyl ester (COOCH3=1)
CBNumber
CB0265359
Molecular Formula
C9H9BrO2
Formula Weight
229.07
MOL File
131001-86-0.mol
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Methyl 2-bromo-3-methylbenzoate Property

Boiling point:
267.4±20.0 °C(Predicted)
Density 
1.433±0.06 g/cm3(Predicted)
refractive index 
1.5530 to 1.5570
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
color 
Red
Water Solubility 
Slightly soluble in water.
CAS DataBase Reference
131001-86-0
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Safety

HS Code 
2916310090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2546
Product name
Methyl 2-Bromo-3-methylbenzoate
Purity
>98.0%(GC)
Packaging
5g
Price
$39
Updated
2025/07/31
TCI Chemical
Product number
M2546
Product name
Methyl 2-Bromo-3-methylbenzoate
Purity
>98.0%(GC)
Packaging
25g
Price
$152
Updated
2025/07/31
Usbiological
Product number
454854
Product name
Methyl 2-bromo-3-methylbenzoate
Packaging
100mg
Price
$305
Updated
2021/12/16
TRC
Product number
M296263
Product name
Methyl 2-Bromo-3-methylbenzoate
Packaging
250mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
073025
Product name
Methyl 2-bromo-3-methylbenzoate
Purity
95+%
Packaging
5g
Price
$57
Updated
2021/12/16
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Methyl 2-bromo-3-methylbenzoate Chemical Properties,Usage,Production

Chemical Properties

brown liquid

Uses

Methyl 2-bromo-3-methylbenzoate is used as pharmaceutical intermediate.

Synthesis

67-56-1

53663-39-1

131001-86-0

A mixed solution of 2-bromo-3-methylbenzoic acid (5 g, 23.2 mmol) and concentrated sulfuric acid (0.5 mL) in anhydrous methanol (100 mL) was heated to reflux for 20 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure by rotary evaporator. The concentrated residue was dissolved in dichloromethane (50 mL) and washed with saturated sodium bicarbonate solution (30 mL) to neutralize the acid. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated again under reduced pressure by rotary evaporator to afford methyl 2-bromo-3-methylbenzoate (4.43 g, 19.3 mmol, 83% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.46 (s, 3H), 3.93 (s, 3H), 7.24 (t, J = 8.0 Hz, 1H), 7.34 (dd, J = 1.0 Hz, J = 8.0 Hz, 1H), 7.46 (dd, J = 1.0 Hz, J = 8.0 Hz, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 2, p. 644 - 651
[2] Journal of the American Chemical Society, 2016, vol. 138, # 18, p. 5813 - 5816
[3] Patent: WO2004/37806, 2004, A1. Location in patent: Page 45
[4] Patent: WO2018/205948, 2018, A1. Location in patent: Page/Page column 49
[5] Patent: WO2004/37806, 2004, A1. Location in patent: Page 71

Methyl 2-bromo-3-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-bromo-3-methylbenzoate manufacturers

Career Henan Chemical Co
Product
Methyl 2-bromo-3-methylbenzoate 131001-86-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg; 10kg; 100kg
Release date
2019-08-30

131001-86-0, Methyl 2-bromo-3-methylbenzoateRelated Search:

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  • METHYL 2-BROMO-3-METHYLBENZOATE
  • 2-Bromo-m-toluic acid methyl ester (COOCH3=1)
  • 2-Bromo-m-toluic acid methyl ester
  • 2-BROMO-3-METHYL-BENZOIC ACID METHYL ESTER
  • Methyl 2-Bromo-3-Methoxynicotinate
  • Methyl 3-Methyl-2-Bromobenzoate
  • Methyl 2-bromo-3-met
  • Benzoic acid, 2-bromo-3-methyl-, methyl ester
  • Methyl2-bromo-3-methylbenzoate,98%
  • Methyl 2-Bromo-m-toluate
  • Methyl 2-Bromo-3-Methylbenzoate/Methyl 3-Methyl-2-Bromobenzoate
  • 131001-86-0
  • Acids & Esters
  • Bromine Compounds
  • Aromatic Esters