Methyl 2-bromo-3-methylbenzoate
- Product Name
- Methyl 2-bromo-3-methylbenzoate
- CAS No.
- 131001-86-0
- Chemical Name
- Methyl 2-bromo-3-methylbenzoate
- Synonyms
- Methyl 2-bromo-3-met;Methyl 2-Bromo-m-toluate;METHYL 2-BROMO-3-METHYLBENZOATE;Methyl 3-Methyl-2-Bromobenzoate;2-Bromo-m-toluic acid methyl ester;Methyl2-bromo-3-methylbenzoate,98%;Methyl 2-Bromo-3-Methoxynicotinate;2-BROMO-3-METHYL-BENZOIC ACID METHYL ESTER;Benzoic acid, 2-bromo-3-methyl-, methyl ester;2-Bromo-m-toluic acid methyl ester (COOCH3=1)
- CBNumber
- CB0265359
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 131001-86-0.mol
Methyl 2-bromo-3-methylbenzoate Property
- Boiling point:
- 267.4±20.0 °C(Predicted)
- Density
- 1.433±0.06 g/cm3(Predicted)
- refractive index
- 1.5530 to 1.5570
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Liquid
- color
- Red
- Water Solubility
- Slightly soluble in water.
- CAS DataBase Reference
- 131001-86-0
Safety
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2546
- Product name
- Methyl 2-Bromo-3-methylbenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- M2546
- Product name
- Methyl 2-Bromo-3-methylbenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- 454854
- Product name
- Methyl 2-bromo-3-methylbenzoate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- M296263
- Product name
- Methyl 2-Bromo-3-methylbenzoate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 073025
- Product name
- Methyl 2-bromo-3-methylbenzoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $57
- Updated
- 2021/12/16
Methyl 2-bromo-3-methylbenzoate Chemical Properties,Usage,Production
Chemical Properties
brown liquid
Uses
Methyl 2-bromo-3-methylbenzoate is used as pharmaceutical intermediate.
Synthesis
67-56-1
53663-39-1
131001-86-0
A mixed solution of 2-bromo-3-methylbenzoic acid (5 g, 23.2 mmol) and concentrated sulfuric acid (0.5 mL) in anhydrous methanol (100 mL) was heated to reflux for 20 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure by rotary evaporator. The concentrated residue was dissolved in dichloromethane (50 mL) and washed with saturated sodium bicarbonate solution (30 mL) to neutralize the acid. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated again under reduced pressure by rotary evaporator to afford methyl 2-bromo-3-methylbenzoate (4.43 g, 19.3 mmol, 83% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.46 (s, 3H), 3.93 (s, 3H), 7.24 (t, J = 8.0 Hz, 1H), 7.34 (dd, J = 1.0 Hz, J = 8.0 Hz, 1H), 7.46 (dd, J = 1.0 Hz, J = 8.0 Hz, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 2, p. 644 - 651
[2] Journal of the American Chemical Society, 2016, vol. 138, # 18, p. 5813 - 5816
[3] Patent: WO2004/37806, 2004, A1. Location in patent: Page 45
[4] Patent: WO2018/205948, 2018, A1. Location in patent: Page/Page column 49
[5] Patent: WO2004/37806, 2004, A1. Location in patent: Page 71
Methyl 2-bromo-3-methylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-bromo-3-methylbenzoate Suppliers
- Tel
- --
- Fax
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- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
- 50
View Lastest Price from Methyl 2-bromo-3-methylbenzoate manufacturers
- Product
- Methyl 2-bromo-3-methylbenzoate 131001-86-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 10kg; 100kg
- Release date
- 2019-08-30