Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

ChemicalBook > CAS DataBase List > Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

Product Name: Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
CAS No.: 211555-08-7
Chemical Name: Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
Synonyms: Janex 3;WHI-P180, >98%;WHI-P180(Janex 3);WHI P180;JANEX3;WHIP180;JANEX-3;3-(6,7-dimethoxyquinazolin-4-ylamino)phenol;3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-;3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference);WHI-P-180,HER1,Janex3,WHI P180,RET,EGFR,Vascular endothelial growth factor receptor,Inhibitor,Janex-3,WHIP180,inhibit,WHI-P180,VEGFR,ErbB-1,Epidermal growth factor receptor
CBNumber: CB02667258
Molecular Formula: C16H15N3O3
Formula Weight: 297.31
MOL File: 211555-08-7.mol

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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Property

Boiling point:: 476.5±40.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 9.58±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 681500
Product name: WHI-P180
Purity: A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.
Packaging: 1MG
Price: $259
Updated: 2024/03/01

Cayman Chemical

Product number: 23452
Product name: WHI-P180
Purity: ≥98%
Packaging: 500μg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 23452
Product name: WHI-P180
Purity: ≥98%
Packaging: 1mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 23452
Product name: WHI-P180
Purity: ≥98%
Packaging: 5mg
Price: $684
Updated: 2024/03/01

ChemScene

Product number: CS-1702
Product name: WHI-P180
Purity: 99.76%
Packaging: 50mg
Price: $1080
Updated: 2021/12/16

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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Chemical Properties,Usage,Production

Biological Activity

WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively.

in vivo

WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.

target

Target	Value
RET (Cell-free assay)	4.5 nM
KDR (Cell-free assay)	66 nM

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Suppliers

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View Lastest Price from Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- manufacturers

Career Henan Chemical Co

Product: Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- 211555-08-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

211555-08-7, Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-Related Search:

4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL WEHI-345 JAK3 INHIBITOR II JAK3 INHIBITOR I 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE WH-4-023 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE 3,4-Dimethoxyphenethylamine 2-Methylsulfonyl-4,6-dimethoxypyrimidine WHI-P97 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE JAK3 Inhibitor

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol

Janex 3

3-(6,7-dimethoxyquinazolin-4-ylamino)phenol

3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference)

WHI P180;JANEX3;WHIP180;JANEX-3

WHI-P180(Janex 3)

WHI-P180, >98%

WHI-P-180,HER1,Janex3,WHI P180,RET,EGFR,Vascular endothelial growth factor receptor,Inhibitor,Janex-3,WHIP180,inhibit,WHI-P180,VEGFR,ErbB-1,Epidermal growth factor receptor

211555-08-7

Inhibitors