ChemicalBook > CAS DataBase List > Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

Product Name
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
CAS No.
211555-08-7
Chemical Name
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
Synonyms
Janex 3;WHI-P180, >98%;WHI-P180(Janex 3);WHI P180;JANEX3;WHIP180;JANEX-3;3-(6,7-dimethoxyquinazolin-4-ylamino)phenol;3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-;3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference);WHI-P-180,HER1,Janex3,WHI P180,RET,EGFR,Vascular endothelial growth factor receptor,Inhibitor,Janex-3,WHIP180,inhibit,WHI-P180,VEGFR,ErbB-1,Epidermal growth factor receptor
CBNumber
CB02667258
Molecular Formula
C16H15N3O3
Formula Weight
297.31
MOL File
211555-08-7.mol
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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Property

Boiling point:
476.5±40.0 °C(Predicted)
Density 
1.336±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
pka
9.58±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
681500
Product name
WHI-P180
Purity
A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.
Packaging
1MG
Price
$259
Updated
2024/03/01
Cayman Chemical
Product number
23452
Product name
WHI-P180
Purity
≥98%
Packaging
500μg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
23452
Product name
WHI-P180
Purity
≥98%
Packaging
1mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
23452
Product name
WHI-P180
Purity
≥98%
Packaging
5mg
Price
$684
Updated
2024/03/01
ChemScene
Product number
CS-1702
Product name
WHI-P180
Purity
99.76%
Packaging
50mg
Price
$1080
Updated
2021/12/16
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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Chemical Properties,Usage,Production

Biological Activity

WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively.

in vivo

WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.

target

TargetValue
RET
(Cell-free assay)
4.5 nM
KDR
(Cell-free assay)
66 nM

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Suppliers

Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
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58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
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55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5800
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50
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
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Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4566
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55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
1005
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55
Nanjing Huang Tai Pharmaceutical Technology Co. Ltd.
Tel
025-58803135 18551845925
Fax
025-58803650
Email
3569572487@qq.com
Country
China
ProdList
274
Advantage
58
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View Lastest Price from Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- manufacturers

Career Henan Chemical Co
Product
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- 211555-08-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

211555-08-7, Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-Related Search:


  • Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
  • 3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol
  • Janex 3
  • 3-(6,7-dimethoxyquinazolin-4-ylamino)phenol
  • 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference)
  • WHI P180;JANEX3;WHIP180;JANEX-3
  • WHI-P180(Janex 3)
  • WHI-P180, >98%
  • WHI-P-180,HER1,Janex3,WHI P180,RET,EGFR,Vascular endothelial growth factor receptor,Inhibitor,Janex-3,WHIP180,inhibit,WHI-P180,VEGFR,ErbB-1,Epidermal growth factor receptor
  • 211555-08-7
  • Inhibitors