ChemicalBook > CAS DataBase List > UNC 0631

UNC 0631

Product Name
UNC 0631
CAS No.
1320288-19-4
Chemical Name
UNC 0631
Synonyms
CS-793;UN 0631;UNC 0631;UNC 0631, >=98%;UNC0631/UNC-0631;UNC 0631 USP/EP/BP;UNC 0631, 10 mM in DMSO;UNC0631; UNC 0631; UNC-0631;N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-(4-isopropyl-1,4-diazepa n-1-yl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;N-(1-(cyclohexylmethyl)piperidin-4- yl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-(3-(piperidin-1- yl)propoxy)quinazolin-4-amine
CBNumber
CB02668659
Molecular Formula
C37H61N7O2
Formula Weight
635.93
MOL File
1320288-19-4.mol
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UNC 0631 Property

Boiling point:
763.4±70.0 °C(Predicted)
Density 
1.114±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥12.66 mg/mL in EtOH with ultrasonic; ≥18.35 mg/mL in DMSO with gentle warming
form 
solid
pka
9.34±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11084
Product name
UNC0631
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
11084
Product name
UNC0631
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
11084
Product name
UNC0631
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
11084
Product name
UNC0631
Purity
≥98%
Packaging
25mg
Price
$353
Updated
2024/03/01
TRC
Product number
C988155
Product name
N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
Packaging
5mg
Price
$100
Updated
2021/12/16
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UNC 0631 Chemical Properties,Usage,Production

Uses

UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.[Cayman Chemical]

Uses

N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine, is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP.

Biological Activity

unc 0631 is a potent inhibitor of protein lysine methyltransferase g9a (also known as kmt1c or ehmt2) with the ic50 value of 4nm [1].unc 0631 has been revealed to inhibit the g9a in sahh-coupled with the ic50 of 4nm. besides, unc 0631 has been found to be highly potent in reducing h3k9me2 levels in mda-mb-231 cells with the icw ic50 of 25nm. in addition, unc 0631 has been shown the high in vitro potency against g9a and improved lipophilicity. besides, unc 0631 has also been reported to have low cell toxicity in mda-mb-231 cells with the ic50 value of 2.8μm in mtt assay. in different cell lines, unc 0631 has been demonstrated to potently reduce h3k9me2 levels with the icw ic50 of 25nm, 18nm, 26nm, 24nm, 51nm, 72nm and 46nm in mda-mb-231, mcf7, pc3, 22rv1, hct116 wt, hct 116 p53 and imr90 cell lines, respectively [1].

IC 50

G9a: 4 nM (IC50)

References

[1] liu f1, barsyte-lovejoy d, allali-hassani a, he y, herold jm, chen x, yates cm, frye sv, brown pj, huang j, vedadi m, arrowsmith ch, jin j.optimization of cellular activity of g9a inhibitors 7-aminoalkoxy-quinazolines. j med chem. 2011 sep 8;54( 17):6139-50.

UNC 0631 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from UNC 0631 manufacturers

Career Henan Chemica Co
Product
UNC 0631 1320288-19-4
Price
US $0.01/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1kg; 5kg; 10kg
Release date
2020-10-28

1320288-19-4, UNC 0631Related Search:

UNC0321 (trifluoroacetate salt) UNC 1999 4SC-202 CEP-32496 N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine PURVALANOL A Testolactone GDC-0077 AGI6780 CC0651 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine IDO-IN-7 XL 228 N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea 5-Azacytidine Vorinostat MM-102 Methotrexate

  • UNC 0631, >=98%
  • N-(1-(cyclohexylmethyl)piperidin-4- yl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-(3-(piperidin-1- yl)propoxy)quinazolin-4-amine
  • N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-(4-isopropyl-1,4-diazepa n-1-yl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
  • UNC 0631
  • UNC0631/UNC-0631
  • N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine
  • N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine UNC0631
  • CS-793
  • UNC0631; UNC 0631; UNC-0631
  • 4-Quinazolinamine, N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-
  • UNC 0631 USP/EP/BP
  • UN 0631
  • UNC 0631, 10 mM in DMSO
  • 1320288-19-4
  • C37H61N7O2
  • Inhibitors
  • Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals