2-Amino-3-hydroxypyridine

Product Name: 2-Amino-3-hydroxypyridine
CAS No.: 16867-03-1
Chemical Name: 2-Amino-3-hydroxypyridine
Synonyms: 2-AMINO-PYRIDIN-3-OL;2-AMINO-3-PYRIDINOL;2-amino-3-pyridi;2-AMINO-3-PYRIDOL;2-amino-3-pyridino;2-Amino-3-hydroxypyr;3-PYRIDINOL, 2-AMINO-;Fampridine Impurity 11;Dopexamine Impurity 14;2-Amino-3-pyridinol 13C
CBNumber: CB0302223
Molecular Formula: C5H6N2O
Formula Weight: 110.11
MOL File: 16867-03-1.mol

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2-Amino-3-hydroxypyridine Property

Melting point:: 168-172 °C (lit.)
Boiling point:: 206.4°C (rough estimate)
Density: 1.2111 (rough estimate)
vapor pressure: 0.007-0.28Pa at 20-50℃
refractive index: 1.4800 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 5.15±0.10(Predicted)
form: Crystalline Powder
color: Grayish-beige to brownish
BRN: 109868
InChIKey: BMTSZVZQNMNPCT-UHFFFAOYSA-N
LogP: -0.25 at 23℃ and pH7.02-7.04
Surface tension: 72.6mN/m at 1.053g/L and 20℃
CAS DataBase Reference: 16867-03-1(CAS DataBase Reference)
NIST Chemistry Reference: 2-Amino-3-hydroxypyridine(16867-03-1)

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Safety

Hazard Codes: Xi,T,Xn
Risk Statements: 36/37/38-25-40
Safety Statements: 26-45-37/39-28A-36-22
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 122513
Product name: 2-Amino-3-hydroxypyridine
Purity: 98%
Packaging: 100g
Price: $416
Updated: 2023/06/20

TCI Chemical

Product number: A1089
Product name: 2-Amino-3-hydroxypyridine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $159
Updated: 2025/07/31

Sigma-Aldrich

Product number: 122513
Product name: 2-Amino-3-hydroxypyridine
Purity: 98%
Packaging: 25g
Price: $135
Updated: 2025/07/31

TRC

Product number: A611658
Product name: 2-Amino-3-hydroxypyridine
Packaging: 50g
Price: $110
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-7S
Product name: 2-Amino-3-hydroxypyridine
Packaging: 500g
Price: $111
Updated: 2021/12/16

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2-Amino-3-hydroxypyridine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 14, p. 203, 1977 DOI: 10.1002/jhet.5570140206

General Description

2-Amino-3-hydroxypyridine forms complexes with number of transition metals. It inhibits the corrosion of aluminium and copper in acidic solutions. It undergoes condensation with 2-hydroxy-1-naphthaldehyde and 2-hydroxybenzaldehyde to form Schiffs bases. It is useful in the preparation of clinical anti-inflammatory analgesics.

Synthesis

15128-82-2

16867-03-1

General method: 3-hydroxy-2-nitropyridine (1 eq.), hexafluoroisopropanol (HFIP, 10 eq.) and iron powder (5 eq.) were added to the reaction tube and mixed. Subsequently, 2N aqueous hydrochloric acid solution was slowly added to the reaction mixture. The reaction mixture was stirred at room temperature for 30 minutes and then neutralized with saturated aqueous sodium bicarbonate (NaHCO3) solution. The organic layer was extracted three times with aqueous sodium bicarbonate and combined. The organic layers were subsequently washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford the target product 2-amino-3-hydroxypyridine.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 37, p. 3646 - 3649
[2] Journal of the Chemical Society, <1957> 4625,
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 350,352
[4] Biochemical Journal, 1950, vol. 46, p. 506
[5] Patent: US1889303, 1930,

2-Amino-3-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-3-hydroxypyridine Suppliers

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View Lastest Price from 2-Amino-3-hydroxypyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-3-hydroxypyridine 16867-03-1
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-09-08

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 2-Amino-3-hydroxypyridine 16867-03-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-08-27

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-3-hydroxypyridine 16867-03-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-04

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2-Amino-3-hydroxypyridine Vetec(TM) reagent grade, 98%

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2-Amino-3-hydroxypyridine ISO 9001：2015 REACH

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Fampridine Impurity 11

Dopexamine Impurity 14

2-Amino-3-hydroxypyridine, 10 mM in DMSO

16867-03-1

16867-03-01

16837-03-1

C5H6NO

AMINE

C5

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C5

Chemical Synthesis

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Pyridines derivates

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pharmacetical

Pyridines, Pyrimidines, Purines and Pteredines