4-(Methylthio)benzaldehyde

Product Name: 4-(Methylthio)benzaldehyde
CAS No.: 3446-89-7
Chemical Name: 4-(Methylthio)benzaldehyde
Synonyms: MTAD;4-ALDEHYDE THIOANISOLE;P-(METHYLTHIO)BENZALDEHYDE;p-Methylmercaptobenzaldehyde;4-(Methylsulfanyl)benzaldehyde;thio)benzaL;AKOS BBS-00003173;4-Thioanisaldehyde;4-Formylthioanisole;4-(methylthio)-benzaldehyd
CBNumber: CB0307859
Molecular Formula: C8H8OS
Formula Weight: 152.21
MOL File: 3446-89-7.mol

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4-(Methylthio)benzaldehyde Property

Melting point:: 6 °C
Boiling point:: 86-90 °C1 mm Hg(lit.)
Density: 1.144 g/mL at 25 °C(lit.)
refractive index: n20/D 1.646(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
Specific Gravity: 1.144
color: Clear yellow
Water Solubility: Not miscible in water.
Sensitive: Stench
BRN: 636158
InChIKey: QRVYABWJVXXOTN-UHFFFAOYSA-N
LogP: 2.24 at 30℃
CAS DataBase Reference: 3446-89-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzaldehyde, 4-(methylthio)-(3446-89-7)
EPA Substance Registry System: Benzaldehyde, 4-(methylthio)- (3446-89-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 23-24/25-36-26-7/9
RIDADR: UN 3334
WGK Germany: 3
F: 13
Hazard Note: Irritant/Stench
TSCA: Yes
HS Code: 29309070

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 222771
Product name: 4-(Methylthio)benzaldehyde
Purity: 95%
Packaging: 10g
Price: $47.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 222771
Product name: 4-(Methylthio)benzaldehyde
Purity: 95%
Packaging: 50g
Price: $140
Updated: 2025/07/31

TCI Chemical

Product number: M0739
Product name: 4-(Methylthio)benzaldehyde
Purity: >97.0%(GC)
Packaging: 25g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: M0739
Product name: 4-(Methylthio)benzaldehyde
Purity: >97.0%(GC)
Packaging: 250g
Price: $200
Updated: 2025/07/31

TRC

Product number: M330660
Product name: 4-(Methylthio)benzaldehyde
Packaging: 10g
Price: $110
Updated: 2021/12/16

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4-(Methylthio)benzaldehyde Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

4-(Methylthio)benzaldehyde is a building block for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of sulfur-containing terpyridine ligands. It is the intermediate for the synthesis of a class of pyrrole derivatives showing analgesic/anti-inflammatory activity.

Synthesis Reference(s)

Synthetic Communications, 24, p. 2665, 1994 DOI: 10.1080/00397919408010580

Synthesis

37794-15-3

3446-89-7

In the standard synthetic method, diphenyl sulfoxide (2.2 g, 0.01 mol) is mixed with brominated silica (18.18 g, 40 mmol Br/g silica) in a nonprotonic solvent such as dichloromethane (2 mL) or carbon tetrachloride. The reaction was carried out at room temperature while atmospheric water needed to be removed for 5 min. Upon completion of the reaction, the product was separated by simple filtration, followed by evaporation of the solvent to give diphenyl sulfide in its pure state (yield 1.84 g, 99%).

References

[1] Synthetic Communications, 2007, vol. 37, # 22, p. 4079 - 4083
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 8, p. 2525 - 2526
[3] Tetrahedron Letters, 2009, vol. 50, # 49, p. 6872 - 6876
[4] Journal of Sulfur Chemistry, 2014, vol. 35, # 1, p. 7 - 13
[5] Journal of Sulfur Chemistry, 2017, vol. 38, # 6, p. 597 - 603

4-(Methylthio)benzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

4-(METHYLTHIO)BENZYLAMINE Sulindac

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4-(Methylthio)benzaldehyde Suppliers

Americas 1 Belgium 2 China 181 Europe 3 Germany 9 India 19 Italy 2 Japan 6 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 16 United States 34 USA 1 Global 280

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Energy Chemical

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View Lastest Price from 4-(Methylthio)benzaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(Methylthio)benzaldehyde 3446-89-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(Methylthio)benzaldehyde 3446-89-7
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(Methylthio)benzaldehyde 3446-89-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

3446-89-7, 4-(Methylthio)benzaldehydeRelated Search:

Mercaptoacetic acid p-Tolualdehyde 2-(Trifluoromethyl)benzaldehyde 3-Mercaptopropionic acid 3-Methoxybenzaldehyde 3-(Trifluoromethyl)benzaldehyde 2-Ethylhexyl mercaptoacetate 4-Hydroxybenzaldehyde 4-Dimethylaminobenzaldehyde o-Anisaldehyde ISOMETHIOZIN p-Anisaldehyde Benzaldehyde Calcium thioglycolate Anisonitrile 4-Methoxycinnamic acid 3,3,4,4-diphenylsulfonetetracarboxylicdianhydride 2-Mercaptoethanol

4-(methylthio)-benzaldehyd

p-Methylmercaptobenzaldehyde

METHYLMERCAPTOBENZALDEHYDE(4-)

4-ALDEHYDE THIOANISOLE

4-METHYLMERCAPTOBENZALDEHYDE

(4-METHYLTHIOCYCLOHEXYL)METHANOL

4-(METHYLTHIO)BENZALDEHYDE

AKOS BBS-00003173

4-(Methylthio)benzaldehyde, 4-Thioanisaldehyde, P-(Methylthio)benzaldehyde

4-(Methylthio)Benzaldehyde97%

4-Thioanisaldehyde

PARA-METHYLTHIOBENZALDEHYDE

4-(METHYLTHIO)BENZALDEHYDE / 4-THIOANISALDEHYDE

4-(METHYLTHIO)BENZALDEHYDE 98+%

Methyl 4-formylphenyl sulfide

Methyl(4-formylphenyl) sulfide

4-(METHYLTHIO)BENZALDEHYDE (4-ALDEHYDETHIOANISOLE)

4-(Methylthio)benzaldehyde,4-(Methylmercapto)benzaldehyde

4-MercaptoMethyl-benzaldehyde

4-Formylthioanisole, 4-(Methylmercapto)benzaldehyde

4-(Methylthio)benzaldehyde, 97% 5ML

P-(METHYLTHIO)BENZALDEHYDE

MTAD

4-(Methylsulfanyl)benzaldehyde

thio)benzaL

4-(Methylthio)benzaldehyde&gt

Benzaldehyde, 4-(methylthio)-

4-Formylthioanisole

TIANFU-CHEM - 4-(Methylthio)benzaldehyde

3446-89-7

CH3SC6H4CHO

Organic Building Blocks

Carbonyl Compounds

Aldehydes

Building Blocks

C8

Aromatic Aldehydes & Derivatives (substituted)