ChemicalBook > CAS DataBase List > 4-Fluorothiophenol
4-Fluorothiophenol
- Product Name
- 4-Fluorothiophenol
- CAS No.
- 371-42-6
- Chemical Name
- 4-Fluorothiophenol
- Synonyms
- 4-Fluorothiphenol;4-FLUOROBENZENETHIOL;4-MERCAPTOFLUOROBENZENE;uorothiophenoL;Fluorothiophenol2;4-Fluorthiophenol;4-fluorothiophene;P-FLUOROTHIOPHENOL;4-FLUOROTHIOPHENOL;p-Fluorobenzenethiol
- CBNumber
- CB0312680
- Molecular Formula
- C6H5FS
- Formula Weight
- 128.17
- MOL File
- 371-42-6.mol
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4-Fluorothiophenol Property
- Melting point:
- 43-46°C
- Boiling point:
- 164-168 °C
- Density
- 1.203 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.550(lit.)
- Flash point:
- 130 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- soluble in Chloroform, Methanol
- form
- Liquid
- pka
- 6.40±0.10(Predicted)
- Specific Gravity
- 1.203
- color
- Clear colorless to light yellow
- Water Solubility
- Not miscible or difficult to mix in water.
- Sensitive
- Stench
- BRN
- 1446350
- InChIKey
- OKIHXNKYYGUVTE-UHFFFAOYSA-N
- CAS DataBase Reference
- 371-42-6(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 10-36/37/38
- Safety Statements
- 26-36-45-16-7/9
- RIDADR
- UN 3336 3/PG 3
- WGK Germany
- 3
- F
- 9-13-23
- Hazard Note
- Irritant/Stench
- TSCA
- N
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29309070
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- F15315
- Product name
- 4-Fluorothiophenol
- Purity
- 98%
- Packaging
- 10g
- Price
- $80
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- F15315
- Product name
- 4-Fluorothiophenol
- Purity
- 98%
- Packaging
- 25g
- Price
- $83.5
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0393
- Product name
- 4-Fluorobenzenethiol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $27
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0393
- Product name
- 4-Fluorobenzenethiol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $74
- Updated
- 2025/07/31
TRC
- Product number
- F489550
- Product name
- 4-Fluorothiophenol
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
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4-Fluorothiophenol Chemical Properties,Usage,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
It is used in the synthesis of Bicalutamide, an anti-cancer drug.
Definition
ChEBI: 4-Fluorothiophenol is a thiol.
Synthesis
460-00-4
371-42-6
The general procedure for the synthesis of p-fluorothiophenol from p-bromofluorobenzene is as follows: In a Schlenk tube, pre-dried in an oven, the aryl halide p-bromofluorobenzene (0.5 mmol), sodium thiosulphate (100 mg), cesium carbonate (1 mmol, 325 mg), an appropriate amount of tris(dibenzylideneacetone)dipalladium/palladium acetate, and Xphos ligands were added in turn to the tube and placed in a magnetic stirring chamber. Sub. The Schlenk tube was evacuated and replaced three times with argon, followed by the addition of an appropriate amount of solvent. The reaction mixture was stirred at room temperature until uniformly dispersed. Next, the reaction tube was placed in an oil bath at 80°C and stirred for 24 hours. Upon completion of the reaction, the solids were separated by filtration and washed with ether. Zinc powder (0.5 g) and 10% hydrochloric acid solution (5 mL) were added to the resulting solid under cooling conditions in an ice water bath. After stirring for 1 h, the reaction mixture was extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product of p-fluorothiophenol of satisfactory purity. For part of the relatively stable product, it can be further purified by column chromatography.
References
[1] Tetrahedron Letters, 2011, vol. 52, # 2, p. 205 - 208
[2] Chemische Berichte, 1939, vol. 72, p. 594
[3] Journal of the Chemical Society, 1962, p. 1062 - 1067
4-Fluorothiophenol Preparation Products And Raw materials
Raw materials
Iodotrimethylsilane
Hexane
Sodium thiosulfate
Fluorobenzene
Sodium borohydride
Chloroform
Chlorosulfonic acid
Dichloromethane
Sodium hydroxide
Isopropyl alcohol
Preparation Products
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View Lastest Price from 4-Fluorothiophenol manufacturers
Hebei Fengjia New Material Co., Ltd
- Product
- 4-Fluorothiophenol 371-42-6
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-09-09
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-Fluorothiophenol 371-42-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-18
Yancheng Green Chemicals Co.,Ltd
- Product
- 4-Fluorothiophenol 371-42-6
- Price
- US $233.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 10 tons
- Release date
- 2021-06-30
371-42-6, 4-FluorothiophenolRelated Search:
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