ChemicalBook > CAS DataBase List > beta-Methyl vinyl phosphate (MAP)

beta-Methyl vinyl phosphate (MAP)

Product Name
beta-Methyl vinyl phosphate (MAP)
CAS No.
90776-59-3
Chemical Name
beta-Methyl vinyl phosphate (MAP)
Synonyms
MVP;BETA-METHYL VINYL PHOSPHATE;4-NITROBENZYL (4R,5S,6S)-3-(DIPHENYLOXY)PHOSPHORYLOXY-6-[(1R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3,2,0]HEPT-2-ENE-2-CARBOXYLATE;EOS-61118;MAP Or MVP;WIDELY MAP;1-beta-Methyl;beta-Methyl vinyl ph;Tebipenem Impurity 1;Biapenem Impurity 10
CBNumber
CB0325503
Molecular Formula
C29H27N2O10P
Formula Weight
594.51
MOL File
90776-59-3.mol
More
Less

beta-Methyl vinyl phosphate (MAP) Property

Melting point:
129-131?C
Boiling point:
722.4±60.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.36±0.20(Predicted)
color 
White to Off-White
InChIKey
STULDTCHQXVRIX-PIYXRGFCSA-N
SMILES
N12[C@@]([H])([C@@H]([C@H](O)C)C1=O)[C@@H](C)C(OP(OC1=CC=CC=C1)(OC1=CC=CC=C1)=O)=C2C(OCC1=CC=C([N+]([O-])=O)C=C1)=O
CAS DataBase Reference
90776-59-3(CAS DataBase Reference)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
N1231
Product name
4-Nitrobenzyl (4R,5S,6S)-3-[(Diphenylphosphono)oxy]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Packaging
5G
Price
$110
Updated
2025/07/31
TCI Chemical
Product number
N1231
Product name
4-Nitrobenzyl (4R,5S,6S)-3-[(Diphenylphosphono)oxy]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Packaging
25G
Price
$329
Updated
2025/07/31
TRC
Product number
N493650
Product name
4-Nitrobenzyl(4R,5S,6S)-3-[(Diphenylphosphono)oxy]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Packaging
5g
Price
$110
Updated
2021/12/16
Usbiological
Product number
486340
Product name
MVP
Packaging
100ul
Price
$499
Updated
2021/12/16
Ark Pharm
Product number
AK-49159
Product name
(4R,5R,6S)-4-Nitrobenzyl3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Purity
97%
Packaging
250mg
Price
$6
Updated
2021/12/16
More
Less

beta-Methyl vinyl phosphate (MAP) Chemical Properties,Usage,Production

Description

A chemical compound.

Uses

Meropenem intermediate. A 1β-methyl carbapenem derivative as antibacterial agent.

Synthesis

104873-15-6

2524-64-3

93711-81-0

General procedure for the synthesis of the compound (CAS: 93711-81-0) from 4-β-methylazabicyclohexyl ketone ester (X) and diphenyl chlorophosphate: a solution of 4-β-methylazabicyclohexyl ketone ester (X) was cooled in an ice bath to -10 to -15 °C, and diisopropylethylamine (14.57 g, 0.113 mol) and diphenyl chlorophosphate were added sequentially, protected by nitrogen gas (27.54 g, 0.102 mol). The reaction mixture was kept stirred at the same temperature for 5 hours until the complete disappearance of compound (X) was confirmed by TLC detection. At the end of the reaction, a large number of white crystals were precipitated from the reaction mixture, after which petroleum ether (300 mL) and 3.5% aqueous sodium dihydrogen phosphate (300 mL) were added to the mixture and the crystals were washed by stirring. After filtration, the filter cake was washed with petroleum ether (100 mL) and water (500 mL) in turn, and after drying, the target product PNB (4R,5S,6S)-3-(diphenoxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid ester (XI) (49.3 g, yield : 81%; purity: 98%). The physicochemical properties of the product were as follows: [α]D25 = +40~+44° (c = 0.5, methanol); melting point: 125-126°C; IR (KBr) νmax cm-1 : 1780, 1745, 1605; 1H NMR (CDCl3) δ: 1.24 (3H, d), 1.35 (3H, d), 2.38 (1H, d, J = 3.2 Hz), 3.35 (1H, dd), 3.52 (1H, m), 4.26 (1H, dd), 4.30 (1H, m), 5.24-5.41 (2H, ABq), 7.29 (10H, m), 7.58 and 8.18 (2H, d).

storage

-20°C Freezer, Under Inert Atmosphere

References

[1] Patent: WO2007/104219, 2007, A1. Location in patent: Page/Page column 15
[2] Journal of Organic Chemistry, 1992, vol. 57, # 15, p. 4243 - 4249
[3] Journal of Antibiotics, 1998, vol. 51, # 8, p. 757 - 770
[4] Patent: WO2007/31858, 2007, A2. Location in patent: Page/Page column 13
[5] Patent: EP2014666, 2009, A1. Location in patent: Page/Page column 10

beta-Methyl vinyl phosphate (MAP) Preparation Products And Raw materials

Raw materials

lead oxide Acetonitrile Ceric ammonium nitrate Ethanol N,N-Dimethylformamide Potassium hydroxide tert-Butyldimethylsilyl chloride Triethylamine Chloroform L-Threonine Ethyl chloroformate Sodium nitrite Imidazole p-Anisidine Ethyl acetate Hydrochloric acid Dichloromethane Methanol Hexamethyldisilazane PETROLEUM ETHER Zinc bromide n-Butyllithium Ethyl chloroacetate

Preparation Products

More
Less

beta-Methyl vinyl phosphate (MAP) Suppliers

Canada 1 China 333 China Hong Kong 1 Europe 2 Germany 2 India 6 Japan 1 South Korea 1 United Kingdom 6 United States 23 Global 376
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Youth (Shanghai) Chemical Technology Co., Ltd.
Tel
--
Fax
--
Email
sales_youthchem@163.com
Country
United States
ProdList
55
Advantage
0
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
ACS International GmbH
Tel
--
Fax
--
Email
info@acsint.com
Country
United States
ProdList
214
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
W & J PharmaChem, Inc.
Tel
--
Fax
--
Email
info@wjpharmachem.com
Country
United States
ProdList
595
Advantage
50
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
More
Less

View Lastest Price from beta-Methyl vinyl phosphate (MAP) manufacturers

Hebei Fengjia New Material Co., Ltd
Product
beta-Methyl vinyl phosphate (MAP) 90776-59-3
Price
US $5.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-09-10
Hebei Chuanghai Biotechnology Co., Ltd
Product
beta-Methyl vinyl phosphate (MAP) 90776-59-3
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2022-09-21
Hebei Yanxi Chemical Co., Ltd.
Product
beta-Methyl vinyl phosphate (MAP) 90776-59-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-16

90776-59-3, beta-Methyl vinyl phosphate (MAP)Related Search:

Allyl methacrylate Chlorodiphenylphosphine Dichlorodiphenylsilane Zinc phosphate Sodium Phosphate Monobasic Monohydrate Clindamycin phosphate Creatine phosphate p-(2-Methoxyethyl) phenol phosphate ester starch 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one Trisodium phosphate METHYLCYCLOPENTADIENE DIMER 1,5-Diphenylcarbazide Side chain for meropenem 2-(METHYLSULFONYL)ETHANOL Dicyclopentadiene 1-Hydroxyethylidene-1,1-diphosphonic acid Ferric phosphate

  • p-nitrobenzyl (1r,5r,6s)-6-[(1r)-1-hydroxyethyl]-2-
  • P-NITROBENZYL (1R,5R,6S)-6-[(1R)-1-HYDROXYETHYL]-2-[(DIPHENYLPHOSPHONO)OXY]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLATE
  • P-NITROBENZYL (1R,5R,6S)-6-[(1R)-HYDROXY ETHYL]-2-[(DIPHENYLPHOSPHONO)OXY]-1-METHYL CARBAPEN-2EM-3-CARBOXYLATE
  • 3-(DIPHENOXY-PHOSPHORYLOXY)-6-(1-HYDROXY-ETHYL)-4-METHYL-7-OXO-1-AZA-BICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID 4-NITRO-BENZYL ESTER
  • (4r,5s,6s)-3-(diphenyloxy)phosphoryloxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate
  • 4-NITROBENZYL (1R,5R,6S)-6-[(1R)-1-HYDROXYETHYL]-2-[(DIPHENYLPHOSPHONO)OXY]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLATE
  • 4-NITROBENZYL-(1R,5R,6S)-6-[(1R)-1-HYDROXYETHYL]-2-[(DIPHENYLPHOSPHONO)OXY]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLIC ACID
  • beta-Methyl vinyl phosphate (MAP)
  • PNB(4R,5S,6S)-3-(diphenyl-oxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate
  • β-METHYL VINYL PHOSPHATE(MAP)
  • 1B-methyl vinyl phosphate
  • 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-,(4-nitrophenyl)methyl ester,(4R,5R,6S)-
  • MVP
  • MAP Or MVP
  • BETA-METHYL VINYL PHOSPHATE
  • (4R,5R,6S)-4-Nitrobenzyl 3-(diphenoxyphosphoryloxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • 1-beta-Methyl
  • 1SS-METHYL VINYL PHOSPHATE (MAP OR MVP)
  • P-Nitrobenzyl(4R,5S,6S)-3-(diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate
  • MAP/MVP-INTERMEDIATE OF MEROPENEM
  • ERTAPENEM INTERMEDIATE, (4R,5R,6S)-3-(DIPHENOXY-PHOSPHORYLOXY)-6-((R)-1-HYDROXY-ETHYL)-4-METHYL-7-OXO-1-AZA-BICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID 4-NITRO-BENZYL ESTER
  • (4R,5S,6S)-3-(DIPHENYLOXY)PHOSPHORYLOXY-6[(1R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABIYCCLO[3,2,0]HEPT-2-ENE-2-CARBOXYLATE
  • 4-NITROBENZYL (4R,5S,6S)-3-(DIPHENYLOXY)PHOSPHORYLOXY-6-[(1R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3,2,0]HEPT-2-ENE-2-CARBOXYLATE
  • 4-Nitrobenzyl (4R,5S,6S)-3-(Diphenyloxy)phosphoryl
  • β-methyl vinyl phosphate
  • 1B-MethylVinylPhosphate(MapOrMvp)(ForMeropenem)
  • 4-Nitrobenzyl-(1R,5R,6S)-6-[(1R)-1-hydroxyethyl]-2-[(diphenylphosphono)oxy]-1-methylcarbapen-2-em-3-ca
  • 4-Nitrobenzyl (4R,5S,6S)-3-[(Diphenylphosphono)oxy]-6-[(R)-1-hydroxyethyl]- 4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • 1-Methylvinylphosphate
  • beta-Methyl vinyl ph
  • MAP beta-Methyl vinyl phosphate
  • 1β-Methyl vinyl phosphate (MAP or MVP)
  • (4R,5R,6S)-4-NITROBENZYL-3-(DIPHENYLOXY)PHOSPHORYLOXY-6-(1R)1-HYDROXYETHYL)4METHYL-
  • (1β-Methyl vinyl phosphate) 4R- 4α, 5β, 6β(R*) -3- (diphenoxyphosphinyl)oxy -6-(1-hydroxyethyl)-4-Methyl-7-oxo-1-azabicyclo 3.2.0 hept-2-ene-2-carboxylic acid, (4-nitrophenyl)Methyl ester
  • MAP(1β-methylcarbapenem nucleus)
  • 4-nitrobenzyl(4R,5R,6S)-3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • Meropenem intermediate: 1b-methyl carbapenem derivative
  • Tebipenem Impurity 1
  • (4R,5S,6S)-4-Nitrobenzyl 3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-
  • (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
  • EOS-61118
  • MAP (meropenem main ring)
  • 4-Nitrobenzyl (4R,5S,6S)-3-(Diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-
  • P-nitrobenzyl(1r,5r,6s)-6-[(1r)-1-hydroxyethyl]-2- [(diphenylphosphono)oxy]-1-methylcarbapen-2-em-3-carboxylate MAP
  • 1β-methyl vinyl phosphate
  • (4R,5S,6S)-3-(Diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-
  • (4-nitrophenyl)methyl (4R,5R,6S)-3-diphenoxyphosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • P-nitrobenzyl(1r,5r,6s)-6-[(1r)-1-hydroxyethyl]-2-[(diphenylphosphono)oxy]-1-methylcarbapen-2-em-3-carboxylate
  • Biapenem Impurity 10
  • (4R,5S,6S)-3-(Diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyeth...
  • WIDELY MAP
  • _x000b_beta-Methyl vinyl phosphate (MAP)
  • Heterocyclic phosphate ester
  • 1β-methyl vinyl phosphate(MAP or MVP)
  • (4-Nitrophenyl)methyl (4R,5R,6S)-3-Diphenoxyphosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-a
  • (3S,4S)-3-((R)-1-(tert-Butyldimethylsilyloxy)ethyl)-4-((R)-1-formylethyl)-2-azetidinone
  • (5R,6S)-6-[(R)-1-Hydroxyethyl]-3-[(R)-2-tetrahydrofuryl]-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylicacid4-oxide
  • MeropenemMainRingMAP