ChemicalBook > CAS DataBase List > Flomoxef

Flomoxef

Product Name
Flomoxef
CAS No.
99665-00-6
Chemical Name
Flomoxef
Synonyms
FMOX;Flumarin;FLOMOXEF;FLOMOEXF;Flomoxef Acid;Flomoxef Monomer;Flomoxef USP/EP/BP;Flomoxef Acid(Sodium);8-Pyridinecarboxamide,N-phenyl-;Flomoxef Sodium、Flumarin、Sodium Flomoxef
CBNumber
CB0328847
Molecular Formula
C15H18F2N6O7S2
Formula Weight
496.47
MOL File
99665-00-6.mol
More
Less

Flomoxef Property

Melting point:
82.5-87.5°
Density 
1.85±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
soluble in DMSO, Methanol
form 
Solid
pka
3.26±0.40(Predicted)
color 
Off-White
CAS DataBase Reference
99665-00-6(CAS DataBase Reference)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
F401850
Product name
Flomoxef
Packaging
1.0mg
Price
$630
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007274
Product name
FLOMOXEF
Purity
95.00%
Packaging
0.5MG
Price
$636
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007274
Product name
FLOMOXEF
Purity
95.00%
Packaging
1G
Price
$1686.3
Updated
2021/12/16
More
Less

Flomoxef Chemical Properties,Usage,Production

Description

Flomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.

Originator

Shionogi (Japan)

Uses

Flomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.

Definition

ChEBI: Flomoxef is a second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents. It has a role as an antibacterial drug. It is a N-acyl-amino acid, an oxacephem and an organonitrogen heterocyclic antibiotic.

brand name

Flumari

Antimicrobial activity

An oxa-cephem which differs from latamoxef in the side chains carried at the 7-amino and C-3 positions, but which retains the 7-methoxy group that confers β-lactamase stability. The methyl group of the methylthiotetrazole side chain of latamoxef has been modified to hydroxymethyl in an attempt to avoid the undesirable side effects, while the side chain at the 7-amino position is F2-CH-S-CH2-.
Activity is similar to that of latamoxef, but activity against Staph. aureus is improved and it is claimed to be a poor inducer of penicillin-binding protein 2′, which is associated with resistance in methicillin-resistant strains.
Intravenous injection of 2 g achieves a peak plasma concentration of around 50 mg/L, falling to 2.6 mg/L after 6 h. The plasma half-life is about 50 min. It appears to be well distributed and penetrates moderately well into lung, mucosal tissue of the middle ear and bone.
Flomoxef does not seem to be prone to the effects on platelet function of latamoxef and it has a less marked effect on vitamin K metabolism. It does not cause a disulfiram-like reaction with alcohol.
It is available in Japan, where it appears safe and effective in a wide range of infections.

Flomoxef Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Flomoxef Suppliers

Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
More
Less

View Lastest Price from Flomoxef manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Flomoxef 99665-00-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-11-05
Hebei Yanxi Chemical Co., Ltd.
Product
Flomoxef 99665-00-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
20tons
Release date
2023-10-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
Flomoxef 99665-00-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

99665-00-6, FlomoxefRelated Search:


  • FLOMOXEF
  • 5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)-
  • FLOMOXEF [5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)- ]
  • 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, (6R,7R)-
  • Flumarin
  • FMOX
  • (-)-(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • [6R,7R,(-)]-7α-[[2-(Difluoromethylthio)acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-[(difluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-,(6R,7R)-
  • (6R,7R)-7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • (6R-cis)7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • (6R-cis)-7-[[[(Difluoromethyl)thio]acetyl]amino]-3_[[[1-(2-hy-droxyethyl)-1H-tetrazol-5-y1]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-[[2-(difluoromethylsulfanyl)acetyl]amino]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-[[2-(difluoromethylthio)-1-oxoethyl]amino]-3-[[[1-(2-hydroxyethyl)-5-tetrazolyl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Flomoxef Sodium、Flumarin、Sodium Flomoxef
  • Flomoxef USP/EP/BP
  • FLOMOEXF
  • Flomoxef Acid
  • 8-Pyridinecarboxamide,N-phenyl-
  • Flomoxef Monomer
  • Flomoxef Acid(Sodium)
  • 99665-00-6
  • C15H18F2N6O7S2
  • C15H18N6O7F2S2
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals