Flomoxef
- Product Name
- Flomoxef
- CAS No.
- 99665-00-6
- Chemical Name
- Flomoxef
- Synonyms
- FMOX;Flumarin;FLOMOXEF;FLOMOEXF;Flomoxef Acid;Flomoxef Monomer;Flomoxef USP/EP/BP;Flomoxef Acid(Sodium);8-Pyridinecarboxamide,N-phenyl-;Flomoxef Sodium、Flumarin、Sodium Flomoxef
- CBNumber
- CB0328847
- Molecular Formula
- C15H18F2N6O7S2
- Formula Weight
- 496.47
- MOL File
- 99665-00-6.mol
Flomoxef Property
- Melting point:
- 82.5-87.5°
- Density
- 1.85±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- soluble in DMSO, Methanol
- form
- Solid
- pka
- 3.26±0.40(Predicted)
- color
- Off-White
- CAS DataBase Reference
- 99665-00-6(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- F401850
- Product name
- Flomoxef
- Packaging
- 1.0mg
- Price
- $630
- Updated
- 2021/12/16
- Product number
- API0007274
- Product name
- FLOMOXEF
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $636
- Updated
- 2021/12/16
- Product number
- API0007274
- Product name
- FLOMOXEF
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1686.3
- Updated
- 2021/12/16
Flomoxef Chemical Properties,Usage,Production
Description
Flomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.
Originator
Shionogi (Japan)
Uses
Flomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.
Definition
ChEBI: Flomoxef is a second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents. It has a role as an antibacterial drug. It is a N-acyl-amino acid, an oxacephem and an organonitrogen heterocyclic antibiotic.
brand name
Flumari
Antimicrobial activity
An oxa-cephem which differs from latamoxef in the side
chains carried at the 7-amino and C-3 positions, but which
retains the 7-methoxy group that confers β-lactamase stability.
The methyl group of the methylthiotetrazole side chain of
latamoxef has been modified to hydroxymethyl in an attempt
to avoid the undesirable side effects, while the side chain at
the 7-amino position is F2-CH-S-CH2-.
Activity is similar to that of latamoxef, but activity against
Staph. aureus is improved and it is claimed to be a poor inducer
of penicillin-binding protein 2′, which is associated with resistance
in methicillin-resistant strains.
Intravenous injection of 2 g achieves a peak plasma concentration
of around 50 mg/L, falling to 2.6 mg/L after 6 h.
The plasma half-life is about 50 min. It appears to be well distributed
and penetrates moderately well into lung, mucosal
tissue of the middle ear and bone.
Flomoxef does not seem to be prone to the effects on platelet
function of latamoxef and it has a less marked effect on
vitamin K metabolism. It does not cause a disulfiram-like
reaction with alcohol.
It is available in Japan, where it appears safe and effective
in a wide range of infections.
Flomoxef Preparation Products And Raw materials
Raw materials
Preparation Products
Flomoxef Suppliers
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
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- Tel
- 1-631-485-4226; 16314854226
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- Tel
- +1-781-999-5354 +1-00000000000
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- United States
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- Tel
- +16313385890
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- United States
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- Sales@BoscheSci.com
- Country
- United States
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View Lastest Price from Flomoxef manufacturers
- Product
- Flomoxef 99665-00-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2021-11-05
- Product
- Flomoxef 99665-00-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2023-10-24
- Product
- Flomoxef 99665-00-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11