L-Phenylalanine benzyl ester hydrochloride

Product Name: L-Phenylalanine benzyl ester hydrochloride
CAS No.: 2462-32-0
Chemical Name: L-Phenylalanine benzyl ester hydrochloride
Synonyms: L-Phenylalanine Benzyl Ester HCl;Nsc522226;PHE-OBZL HCL;anine BenzyL;H-PHE-OBZL HCL;H-PHE-OBZL.HCI;H-PHE-OBZL·HCL;H-L-Phe-OBzl*HCl;PHENYLALANINE-OBZL HCL;H-Phe-OBzl hydrochloride
CBNumber: CB0330248
Molecular Formula: C16H18ClNO2
Formula Weight: 291.77
MOL File: 2462-32-0.mol

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L-Phenylalanine benzyl ester hydrochloride Property

Melting point:: 197-200 °C
alpha: -13 º (c=1% in 80% acetic acid)
refractive index: -12 ° (C=1, 80% acetic acid)
storage temp.: Inert atmosphere,Room Temperature
Water Solubility: Soluble in water
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Crystalline Powder
color: White to off-white
optical activity: [α]20/D 13±1°, c = 1% in acetic acid: water (4:1)
BRN: 3919200
InChI: InChI=1/C16H17NO2.ClH/c17-15(11-13-7-3-1-4-8-13)16(18)19-12-14-9-5-2-6-10-14;/h1-10,15H,11-12,17H2;1H/t15-;/s3
InChIKey: CEXFHIYDTRNBJD-AVAJOTNLNA-N
SMILES: C1(=CC=CC=C1)C[C@H](N)C(=O)OCC1C=CC=CC=1.Cl |&1:7,r|
CAS DataBase Reference: 2462-32-0(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 78060
Product name: L-Phenylalanine benzyl ester hydrochloride
Purity: ≥99.0% (AT)
Packaging: 5g
Price: $68.67
Updated: 2025/07/31

TCI Chemical

Product number: P1718
Product name: L-Phenylalanine Benzyl Ester Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: P1718
Product name: L-Phenylalanine Benzyl Ester Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $125
Updated: 2025/07/31

Usbiological

Product number: 239373
Product name: L-Phenylalanine benzyl ester hydrochloride
Packaging: 5g
Price: $170
Updated: 2021/12/16

TRC

Product number: P319445
Product name: L-Phenylalanine Benzyl Ester Hydrochloride
Packaging: 5g
Price: $70
Updated: 2021/12/16

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L-Phenylalanine benzyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

L-Phenylalanine Benzyl Ester Hydrochloride is a commonly used reactant for the synthesis of L-isoserine derivatives as aminopeptidase N inhibitors and PF-04449913 as a potent and orally bioavailable inhibitor of smoothened.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

66617-58-1

2462-32-0

The general procedure for the synthesis of L-phenylalanine benzyl ester hydrochloride from (S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropionate was as follows: benzyl (2S)-2-(tert-butoxycarbonylamino)-3-phenylpropionate (12.8 g, 36 mmol) was dissolved in an ether solution of 2 M HCl (90 mL) and a dioxane solution of 4 M HCl (18 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was diluted with hexane (100 mL) and subsequently filtered to afford L-phenylalanine benzyl ester hydrochloride (7.98 g, 76% yield) as a white fine powder. The product was characterized by 1H NMR (CD3OD, 400 MHz): δ (ppm) 7.40-7.15 (m, 10H), 5.23 (s, 2H), 4.36-4.31 (m, 1H), 3.26-3.12 (m, 2H).

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 9, p. 4235 - 4243
[2] Patent: US9441012, 2016, B2. Location in patent: Page/Page column 67
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 14, p. 1497 - 1499
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, vol. 27, # 2, p. 302 - 310
[5] Chemistry - A European Journal, 2012, vol. 18, # 21, p. 6528 - 6541

L-Phenylalanine benzyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-Phenylalanine benzyl ester hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Phe-OBzl.HCl 2462-32-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-18

Hebei Chuanghai Biotechnology Co., Ltd

Product: L-Phenylalanine benzyl ester hydrochloride 2462-32-0
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-Phenylalanine benzyl ester hydrochloride 2462-32-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

2462-32-0, L-Phenylalanine benzyl ester hydrochlorideRelated Search:

Methyl acrylate Benzyl alcohol Topotecan hydrochloride PHENYL VALERATE L-Alanine methyl ester hydrochloride Ethyl L-phenylalaninate hydrochloride DL-Phenylalanine N-(tert-Butoxycarbonyl)-L-phenylalanine Benzyl benzoate D-Phenylalanine Benzyl bromide Phenprobamate Ethyl 3-aminopropanoate hydrochloride Tris(trimethylsilyl)phosphate Methyl L-phenylalaninate hydrochloride L-Phenylglycinol L-Phenylalanine L-Alanine isopropyl ester hydrochloride

benzyl 3-phenyl-L-alaninate hydrochloride

L-Phenylalanine Benzyl Ester HCl

H-PHE-OBZL·HCL

L-Phenylalanine benzyl ester hydrochloride≥ 99% (HPLC)

H-PHE-OBZL HCL

PHE-OBZL HCL

PHENYLALANINE-OBZL HCL

L-PHENYLALANINE BENZYL ESTER HYDROCHLORIDE

L-PHENYLALANINE BENZYL ESTER HYDROCHLORIDE SALT

H-PHE-OBZL.HCI

H-L-Phe-OBzl*HCl

Nsc522226

l-phenylalanine benzyl ester hydrovhloride

H-Phe-OBzl hydrochloride

benzyl (2S)-2-aMino-3-phenylpropanoate hydrochloride

(S)-benzyl 2-aMino-3-phenylpropanoate hydrochloride

Phenylalanine, benzyl ester hydrochloride

L-PhenylalanineBenzylEsterHydrochloride&gt

anine BenzyL

L-Phenylalanine, phenylmethyl ester, hydrochloride (1:1)

L-Phenylalanine benzyl ester hydrochloride USP/EP/BP

L-Phenylalanine Benzyl Ester Hydrochloride extrapure, 99%

<sc>L</sc>-Phenylalanine benzyl ester hydrochloride

L-Phenylalanine benzyl ester hydrochloride 99%

2462-32-0

462-32-0

2462-30-0

C16H17NO2ClH

C6H5CH2CHNH2COOCH2C6H5HCl

C16H17NO2HCl

C6H17NO2HCl

Amino Acid Derivatives

Phenylalanine

Peptide Synthesis

Specialty Synthesis

Phenylalanine [Phe, F]

Amino Acids and Derivatives

Amino Acid Benzyl Esters

Amino Acids (C-Protected)

Biochemistry

Amino hydrochloride

Amino Acid Derivatives

Peptide Synthesis

Phenylalanine

Amino Acid Derivatives

Amino Acids