ChemicalBook > CAS DataBase List > ML-327

ML-327

Product Name
ML-327
CAS No.
1883510-31-3
Chemical Name
ML-327
Synonyms
-327;ML-327;ML327;ML-327;ML 327;ML327, 10 mM in DMSO;Abmole M9309-2mg ML327 1883510-31-3;ML-327,Autophagy,Myc,Inhibitor,ML 327,ML327,inhibit,c-Myc;N-(3-(2-Oxo-1,2-dihydropyridine-3-carboxamido)propyl)-5-phenylisoxazole-3-carboxamide;3-Pyridinecarboxamide, 1,2-dihydro-2-oxo-N-[3-[[(5-phenyl-3-isoxazolyl)carbonyl]amino]propyl]-
CBNumber
CB03364073
Molecular Formula
C19H18N4O4
Formula Weight
366.37
MOL File
1883510-31-3.mol
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ML-327 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 32 mg/mL (87.34 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M425195
Product name
ML327
Packaging
1mg
Price
$660
Updated
2021/12/16
Crysdot
Product number
CD31004951
Product name
ML-327
Purity
97%
Packaging
1g
Price
$842
Updated
2021/12/16
DC Chemicals
Product number
DC10711
Product name
ML-327
Purity
>98%
Packaging
250mg
Price
$1050
Updated
2021/12/16
Crysdot
Product number
CD31004951
Product name
ML-327
Purity
97%
Packaging
50mg
Price
$108
Updated
2021/12/16
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ML-327 Chemical Properties,Usage,Production

Uses

ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).

Biological Activity

ML327 is a regulator of E-cadherin transcription th at restores E-cadherin expression in cancer cell lines and partially reverses Epithelial-to-Mesenchymal Transition (EMT). It is a potent inducer of mesenchymal-to-epithelial transition (MET) in epithelial cancers. Apparently ML327 blocks MYC expression in neuroblastomas. It induces apoptosis in cancer cells and sensitizes Ewing sarcoma cells to TRAIL.

in vivo

ML327 treatment significantly reduces tumor volume by three-fold over the two-week treatment period (p=0.02). Tumor explant weights are approximately three-fold smaller in the ML327-treated mice (p=0.01). Mice treated with ML327 lost 12% more body weight than vehicle treated mice. ML327 treatment results in a two-fold decrease in MYCN expression, confirming that ML327 inhibits xenograft MYCN expression (p=0.0035)[1].

ML-327 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML-327 Suppliers

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1883510-31-3, ML-327Related Search:

Decyltrimethylammonium chloride Nodinitib-1 9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine PTP1B-IN-2 ML264 ML216 ML385 ML365 ML 141 ML355 M348 ml390 (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

  • ML-327
  • ML327;ML-327;ML 327
  • -327
  • 3-Pyridinecarboxamide, 1,2-dihydro-2-oxo-N-[3-[[(5-phenyl-3-isoxazolyl)carbonyl]amino]propyl]-
  • N-(3-(2-Oxo-1,2-dihydropyridine-3-carboxamido)propyl)-5-phenylisoxazole-3-carboxamide
  • ML-327,Autophagy,Myc,Inhibitor,ML 327,ML327,inhibit,c-Myc
  • ML327, 10 mM in DMSO
  • Abmole M9309-2mg ML327 1883510-31-3
  • 1883510-31-3