ChemicalBook > CAS DataBase List > 2-Bromo-5-iodopyridine

2-Bromo-5-iodopyridine

Product Name
2-Bromo-5-iodopyridine
CAS No.
73290-22-9
Chemical Name
2-Bromo-5-iodopyridine
Synonyms
2-BROMO-5-IODOPYRIDINE;2-Bromo-5-Iodine Pyridine;Pyridine, 2-bromo-5-iodo-;2-Bromo-5-iodopyridine 96%;2-Bromo-5-iodopyridine,97%;2-Bromo-5-iodopyridine >JR-6787, 2-Bromo-5-iodopyridine, 97%;2-Bromo-5-iodopyridine ISO 9001：2015 REACH
CBNumber
CB0338941
Molecular Formula
C5H3BrIN
Formula Weight
283.89
MOL File
73290-22-9.mol
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2-Bromo-5-iodopyridine Property

Melting point:
121-123 °C (lit.)
Boiling point:
278.6±20.0 °C(Predicted)
Density 
2.347±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-1.23±0.10(Predicted)
form 
Powder
color 
White to off-white
Sensitive 
Light Sensitive
BRN 
109100
InChI
InChI=1S/C5H3BrIN/c6-5-2-1-4(7)3-8-5/h1-3H
InChIKey
LLKRSJVPTKFSLS-UHFFFAOYSA-N
SMILES
C1(Br)=NC=C(I)C=C1
CAS DataBase Reference
73290-22-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41
Safety Statements 
26-36/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
652598
Product name
2-Bromo-5-iodopyridine
Purity
96%
Packaging
5g
Price
$93.94
Updated
2025/07/31
Sigma-Aldrich
Product number
652598
Product name
2-Bromo-5-iodopyridine
Purity
96%
Packaging
25g
Price
$157
Updated
2025/07/31
TCI Chemical
Product number
B3765
Product name
2-Bromo-5-iodopyridine
Purity
>97.0%(GC)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
B3765
Product name
2-Bromo-5-iodopyridine
Purity
>97.0%(GC)
Packaging
25g
Price
$87
Updated
2025/07/31
TRC
Product number
B688875
Product name
2-Bromo-5-iodopyridine
Packaging
10g
Price
$140
Updated
2021/12/16
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2-Bromo-5-iodopyridine Chemical Properties,Usage,Production

Chemical Properties

White crystalline

Uses

2-Bromo-5-iodopyridine can be used to develop fluorescent compounds (manisyl-substituted terpyridine, bipyridine, and phenanthroline). It is also a useful reagent for investigating the structure/activity relationships of non-nucleoside adenosine kinase inhibitors.

Synthesis

20511-12-0

73290-22-9

General procedure for the synthesis of 2-bromo-5-iodopyridine from 2-amino-5-iodopyridine: Bromine (3 mL) was slowly added dropwise to a mixture of 2-amino-5-iodopyridine (5 g, 20 mmol) dissolved in 48% aqueous hydrobromic acid (10 mL), and the reaction system was cooled by an ice bath to maintain the reaction at low temperature. Subsequently, sodium nitrite (3.4 g, dissolved in 5 mL of water) solution was added dropwise, and the reaction temperature was controlled not to exceed 15 °C. After the dropwise addition, a solution of sodium hydroxide (16 g) in water (40 mL) was added. A brown solid precipitated from the reaction mixture and was extracted with dichloromethane (50 mL). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the target product 2-bromo-5-iodopyridine (4.4 g, 78% yield).

References

[1] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 5, p. 2656 - 2663
[2] Journal of Organic Chemistry, 2009, vol. 74, # 15, p. 5228 - 5236
[3] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 3, p. 467 - 479
[4] Patent: WO2005/92304, 2005, A2. Location in patent: Page/Page column 42
[5] Tetrahedron, 2002, vol. 58, # 14, p. 2885 - 2890

2-Bromo-5-iodopyridine Preparation Products And Raw materials

Raw materials

1,2-DIIODOETHANE Tetrahydrofuran 2,5-Dibromopyridine n-Butyllithium

Preparation Products

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2-Bromo-5-iodopyridine Suppliers

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View Lastest Price from 2-Bromo-5-iodopyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Bromo-5-iodopyridine 73290-22-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Bromo-5-iodopyridine 73290-22-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-17
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Bromo-5-iodopyridine 73290-22-9
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24

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