2-Bromo-5-iodopyridine
- Product Name
- 2-Bromo-5-iodopyridine
- CAS No.
- 73290-22-9
- Chemical Name
- 2-Bromo-5-iodopyridine
- Synonyms
- 2-BROMO-5-IODOPYRIDINE;2-Bromo-5-Iodine Pyridine;Pyridine, 2-bromo-5-iodo-;2-Bromo-5-iodopyridine 96%;2-Bromo-5-iodopyridine,97%;2-Bromo-5-iodopyridine >JR-6787, 2-Bromo-5-iodopyridine, 97%;2-Bromo-5-iodopyridine ISO 9001：2015 REACH
- CBNumber
- CB0338941
- Molecular Formula
- C5H3BrIN
- Formula Weight
- 283.89
- MOL File
- 73290-22-9.mol
2-Bromo-5-iodopyridine Property
- Melting point:
- 121-123 °C (lit.)
- Boiling point:
- 278.6±20.0 °C(Predicted)
- Density
- 2.347±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.23±0.10(Predicted)
- form
- Powder
- color
- White to off-white
- Sensitive
- Light Sensitive
- BRN
- 109100
- InChI
- InChI=1S/C5H3BrIN/c6-5-2-1-4(7)3-8-5/h1-3H
- InChIKey
- LLKRSJVPTKFSLS-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C(I)C=C1
- CAS DataBase Reference
- 73290-22-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 652598
- Product name
- 2-Bromo-5-iodopyridine
- Purity
- 96%
- Packaging
- 5g
- Price
- $93.94
- Updated
- 2025/07/31
- Product number
- 652598
- Product name
- 2-Bromo-5-iodopyridine
- Purity
- 96%
- Packaging
- 25g
- Price
- $157
- Updated
- 2025/07/31
- Product number
- B3765
- Product name
- 2-Bromo-5-iodopyridine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- B3765
- Product name
- 2-Bromo-5-iodopyridine
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $87
- Updated
- 2025/07/31
- Product number
- B688875
- Product name
- 2-Bromo-5-iodopyridine
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
2-Bromo-5-iodopyridine Chemical Properties,Usage,Production
Chemical Properties
White crystalline
Uses
2-Bromo-5-iodopyridine can be used to develop fluorescent compounds (manisyl-substituted terpyridine, bipyridine, and phenanthroline). It is also a useful reagent for investigating the structure/activity relationships of non-nucleoside adenosine kinase inhibitors.
Synthesis
20511-12-0
73290-22-9
General procedure for the synthesis of 2-bromo-5-iodopyridine from 2-amino-5-iodopyridine: Bromine (3 mL) was slowly added dropwise to a mixture of 2-amino-5-iodopyridine (5 g, 20 mmol) dissolved in 48% aqueous hydrobromic acid (10 mL), and the reaction system was cooled by an ice bath to maintain the reaction at low temperature. Subsequently, sodium nitrite (3.4 g, dissolved in 5 mL of water) solution was added dropwise, and the reaction temperature was controlled not to exceed 15 °C. After the dropwise addition, a solution of sodium hydroxide (16 g) in water (40 mL) was added. A brown solid precipitated from the reaction mixture and was extracted with dichloromethane (50 mL). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the target product 2-bromo-5-iodopyridine (4.4 g, 78% yield).
References
[1] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 5, p. 2656 - 2663
[2] Journal of Organic Chemistry, 2009, vol. 74, # 15, p. 5228 - 5236
[3] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 3, p. 467 - 479
[4] Patent: WO2005/92304, 2005, A2. Location in patent: Page/Page column 42
[5] Tetrahedron, 2002, vol. 58, # 14, p. 2885 - 2890
2-Bromo-5-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-5-iodopyridine Suppliers
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View Lastest Price from 2-Bromo-5-iodopyridine manufacturers
- Product
- 2-Bromo-5-iodopyridine 73290-22-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Bromo-5-iodopyridine 73290-22-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-17
- Product
- 2-Bromo-5-iodopyridine 73290-22-9
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24