ChemicalBook > CAS DataBase List > 2-(Cyanomethyl)benzimidazole

2-(Cyanomethyl)benzimidazole

Product Name
2-(Cyanomethyl)benzimidazole
CAS No.
4414-88-4
Chemical Name
2-(Cyanomethyl)benzimidazole
Synonyms
2-(1H-benzo[d]imidazol-2-yl)acetonitrile;1h-benzimidazole-2-acetonitrile;AKOS BC-1506;96.0%(GC&AURORA KA-5429;IFLAB-BB F0266-2601;LABOTEST-BB LT00159463;2-kyanmethylbenzimidazol;CYANOMETHYLBENZIMIDAZOLE;2-cyanomethyl-benzimidazol
CBNumber
CB0351933
Molecular Formula
C9H7N3
Formula Weight
157.17
MOL File
4414-88-4.mol
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2-(Cyanomethyl)benzimidazole Property

Melting point:
200-205 °C (dec.)(lit.)
Boiling point:
271.83°C (rough estimate)
Density 
1.2279 (rough estimate)
refractive index 
1.5330 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
11.01±0.10(Predicted)
color 
White to Brown
Water Solubility 
Insoluble in water.
BRN 
128461
InChIKey
BWOVACANEIVHST-UHFFFAOYSA-N
CAS DataBase Reference
4414-88-4(CAS DataBase Reference)
EPA Substance Registry System
1H-Benzimidazole-2-acetonitrile (4414-88-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-37/39-24/25
RIDADR 
3276
WGK Germany 
3
RTECS 
DD5650000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29332900
Toxicity
LD50 ivn-mus: 56 mg/kg CSLNX* NX#04148
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B5291
Product name
(2-Benzimidazolyl)acetonitrile
Purity
97%
Packaging
10g
Price
$97.2
Updated
2025/07/31
TCI Chemical
Product number
B2821
Product name
(2-Benzimidazolyl)acetonitrile
Purity
>96.0%(GC)(T)
Packaging
5g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
B2821
Product name
(2-Benzimidazolyl)acetonitrile
Purity
>96.0%(GC)(T)
Packaging
25g
Price
$151
Updated
2025/07/31
TRC
Product number
C990120
Product name
2-(Cyanomethyl)benzimidazole
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
C990120
Product name
2-(Cyanomethyl)benzimidazole
Packaging
500mg
Price
$65
Updated
2021/12/16
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2-(Cyanomethyl)benzimidazole Chemical Properties,Usage,Production

Chemical Properties

LIGHT BEIGE FINE CRYSTALLINE POWDER

Uses

2-Benzimidazoleacetonitrile, is used as a pharmaceutical intermediate. It is also used as an intermediate in organic synthesis.

Safety Profile

Poison by intravenous route. Seealso NITRILES. When heated to decomposition it emitstoxic fumes of NOx.

Synthesis

105-56-6

95-54-5

4414-88-4

To the dry solid of o-phenylenediamine (1.08 g, 10 mmol) was added ethyl cyanoacetate (1.13 g, 10 mmol). The reaction mixture was placed in an oil bath and heated at 120 °C for 30 min, followed by cooling to room temperature. Upon completion of the reaction, the product was collected by filtration and ground with diethyl ether for purification. Finally, recrystallization was carried out from ethanol to give 2-cyanomethylbenzimidazole.

References

[1] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 3, p. 309 - 318
[2] ChemMedChem, 2016, vol. 11, # 5, p. 539 - 548
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 853 - 869
[4] European Journal of Medicinal Chemistry, 2017, vol. 136, p. 270 - 282
[5] Chinese Chemical Letters, 2010, vol. 21, # 5, p. 519 - 523

2-(Cyanomethyl)benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

COUMARIN 7 Solvent Red 196 Coumarin 30 Solvent Red 197
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View Lastest Price from 2-(Cyanomethyl)benzimidazole manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(2-Benzimidazolyl)acetonitrile 4414-88-4
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(Cyanomethyl)benzimidazole 4414-88-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(Cyanomethyl)benzimidazole 4414-88-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

4414-88-4, 2-(Cyanomethyl)benzimidazoleRelated Search:

Phenformin Acetonitrile 2-Phenylbenzimidazole-5-sulfonic acid 2-GUANIDINOBENZIMIDAZOLE 2-Phenylbenzimidazole 2-Methylbenzimidazole 5-Nitrobenzimidazole Benzimidazole 2-Chloromethylbenzimidazole (1-Methyl-1H-benzoimidazol-2-yl)acetonitrile 2-(1H-BENZIMIDAZOL-2-YL)-4-CHLORO-3-OXOBUTANENITRILE Alkyl benzimidazole benzimidazolone 2-(Cyanomethyl)benzimidazole AKOS BC-1508 BUTTPARK 125\40-73 AURORA 12449 2-(1H-BENZO[D]IMIDAZOL-2-YL)-2-(5-BROMO-2-CHLORO-6-METHYLPYRIMIDIN-4-YL)ACETONITRILE

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