Ethyl 2-aminopyridine-3-carboxylate
- Product Name
- Ethyl 2-aminopyridine-3-carboxylate
- CAS No.
- 13362-26-0
- Chemical Name
- Ethyl 2-aminopyridine-3-carboxylate
- Synonyms
- AKOS 90517;BUTTPARK 23\07-65;RARECHEM AL BI 1234;Nicorandil Impurity 47;ETHYL 2-AMINONICOTINATE;Ethyl2-Aminonicotinate>Nicotinic Acid Impurity 12;Nicotinic acid Impurity 10;Ethyl 2-aMinonicotinic acid;Ethyl 2-aminonicotinate ,97%
- CBNumber
- CB0352475
- Molecular Formula
- C8H10N2O2
- Formula Weight
- 166.18
- MOL File
- 13362-26-0.mol
Ethyl 2-aminopyridine-3-carboxylate Property
- Melting point:
- 96-98°C
- Boiling point:
- 133°C/12mmHg(lit.)
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO, Methanol
- pka
- 4.84±0.36(Predicted)
- form
- Solid
- color
- Yellow
- InChI
- InChI=1S/C8H10N2O2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3,(H2,9,10)
- InChIKey
- KIAGEDYOPMHRRB-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC=C1C(OCC)=O
- CAS DataBase Reference
- 13362-26-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E1146
- Product name
- Ethyl 2-Aminonicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- E1146
- Product name
- Ethyl 2-Aminonicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $127
- Updated
- 2025/07/31
- Product number
- E705500
- Product name
- Ethyl2-Aminopyridine-3-carboxylate
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR15285
- Product name
- Ethyl 2-Aminonicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4H58-1-W9
- Product name
- Ethyl 2-aminonicotinate
- Purity
- 98%
- Packaging
- 5G
- Price
- $24
- Updated
- 2021/12/16
Ethyl 2-aminopyridine-3-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
A pyrimidine derivative with diuretic activity.
Synthesis
5345-47-1
64-17-5
13362-26-0
2-Aminonicotinic acid (1) (5 g, 36 mmol) and ethanol (100 mL) were used as feedstock to which concentrated sulfuric acid (10 mL) was added. The reaction mixture was heated to reflux for 16 hours and subsequently cooled to room temperature. The completion of the reaction was confirmed by LC-MS analysis. The volatiles were removed under vacuum, water was added, and the crude product was alkalized with 1N NaOH solution to pH 8.0. The product was extracted twice with ethyl acetate, and the organic phases were combined, dried over magnesium sulfate, and then concentrated to afford ethyl (2) 2-aminonicotinate (6.0 g, 100% yield) as a white crystalline solid. hplc-ms analysis results: retention time t R = 0.41 min (UV 254 nm); mass calculated value C8H10N2O2 166.1, measured value LCMS m/z 167.1 (M + H).
References
[1] Patent: WO2008/82490, 2008, A2. Location in patent: Page/Page column 70
[2] Patent: TWI525093, 2016, B. Location in patent: Page/Page column 101;
[3] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 64; 134
[4] Patent: WO2007/86080, 2007, A2. Location in patent: Page/Page column 37
[5] Heterocycles, 1993, vol. 36, # 11, p. 2513 - 2522
Ethyl 2-aminopyridine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-aminopyridine-3-carboxylate manufacturers
- Product
- Ethyl 2-aminopyridine-3-carboxylate 13362-26-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
- Product
- Ethyl 2-aminopyridine-3-carboxylate 13362-26-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- Ethyl 2-aminopyridine-3-carboxylate 13362-26-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11