5-HYDROXYINDOLE-3-ACETIC ACID
- Product Name
- 5-HYDROXYINDOLE-3-ACETIC ACID
- CAS No.
- 54-16-0
- Chemical Name
- 5-HYDROXYINDOLE-3-ACETIC ACID
- Synonyms
- 5-HIAA;HIAA;2-(5-hydroxy-1H-indol-3-yl)acetic acid;5-oxyindoleaceticacid;5-HYDROXY-3-INDOLEACETIC ACID;5&＃039;5-HO-IAA;NSC 90432;Nature Product;TIMTEC-BB SBB003639
- CBNumber
- CB0362913
- Molecular Formula
- C10H9NO3
- Formula Weight
- 191.18
- MOL File
- 54-16-0.mol
5-HYDROXYINDOLE-3-ACETIC ACID Property
- Melting point:
- 161-164 °C (dec.) (lit.)
- Boiling point:
- 326.92°C (rough estimate)
- Density
- 1.2722 (rough estimate)
- refractive index
- 1.5310 (estimate)
- storage temp.
- -20°C
- solubility
- Soluble in ethanol (50 mg/ml).
- pka
- 4.54±0.30(Predicted)
- form
- crystalline
- color
- off-white to purple
- Sensitive
- Light Sensitive
- BRN
- 168797
- Stability:
- Air Sensitive, Light Sensitive
- InChIKey
- DUUGKQCEGZLZNO-UHFFFAOYSA-N
- CAS DataBase Reference
- 54-16-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- H8876
- Product name
- 5-Hydroxyindole-3-acetic acid
- Purity
- ≥98% (HPLC), crystalline
- Packaging
- 100mg
- Price
- $36.1
- Updated
- 2024/03/01
- Product number
- H8876
- Product name
- 5-Hydroxyindole-3-acetic acid
- Purity
- ≥98% (HPLC), crystalline
- Packaging
- 1g
- Price
- $178
- Updated
- 2024/03/01
- Product number
- H0355
- Product name
- 5-Hydroxyindole-3-acetic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $320
- Updated
- 2024/03/01
- Product number
- H0355
- Product name
- 5-Hydroxyindole-3-acetic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 100mg
- Price
- $43
- Updated
- 2024/03/01
- Product number
- J61435
- Product name
- 5-Hydroxyindole-3-acetic acid, 98%
- Packaging
- 500mg
- Price
- $77.65
- Updated
- 2024/03/01
5-HYDROXYINDOLE-3-ACETIC ACID Chemical Properties,Usage,Production
Description
5-hydroxy Indole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT; ). It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for detection of neuroendocrine tumors and an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. 5-HIAA has also been associated with autism, insomnia, and chronic migraine.
Chemical Properties
beige crystalline powder
Uses
5-Hydroxyindole-3-acetic acid is a major serotonin metabolite.
Uses
5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.
Definition
ChEBI: A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
General Description
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Mechanism of action
The primary product of the metabolism of serotonin. Formed by the oxidative deamination of serotonin by monoamine oxidase, presumably the A isozyme, 5-HIAA is subsequently cleared by an active transport mechanism. Unlike serotonin, 5-HIAA is not a neurotransmitter and thus its formation contributes to the termination of the synaptic actions of serotonin. Inhibition of monoamine oxidase activity enhances and prolongs the actions of serotonin.
5-HYDROXYINDOLE-3-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-HYDROXYINDOLE-3-ACETIC ACID manufacturers
- Product
- (5-hydroxyindol-3-yl)acetic acid 54-16-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-14