Ethyl (3S)-piperidine-3-carboxylate

Product Name: Ethyl (3S)-piperidine-3-carboxylate
CAS No.: 37675-18-6
Chemical Name: Ethyl (3S)-piperidine-3-carboxylate
Synonyms: H-S-3PIP-OET;(S)-nipecotate;(S)-ETHYL-NIPECOTATE;Ethyl L-nipecotate, 97%;ETHYL (S)-(+)-NIPECOTATE;(S)-(+)-ETHYL NIPECOTATE;(3s)-(+)-ethyl Nipecotate;(S)-1-BOC-ETHYL NIPECOTATE;(S)-Ethyl piperidine-3-ca...;(S)-NIPECOTIC ACID ETHYL ESTER
CBNumber: CB0380304
Molecular Formula: C8H15NO2
Formula Weight: 157.21
MOL File: 37675-18-6.mol

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Ethyl (3S)-piperidine-3-carboxylate Property

Boiling point:: 102-104 °C/7 mmHg(lit.)
Density: 1.043 g/mL at 25 °C
refractive index: n20/D 1.471
Flash point:: 77 °C
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 9.35±0.10(Predicted)
form: clear liquid
color: Colorless to Almost colorless
Specific Gravity: 1.012
optical activity: -3.4°(C=0.01 g/ml, CHCL3, 20°C, 589nm)
Sensitive: Light, Air & Moisture Sensitive
CAS DataBase Reference: 37675-18-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41
Safety Statements: 26-36/37/39-39-36
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 696439
Product name: (S)-Ethyl piperidine-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $53.27
Updated: 2025/07/31

TCI Chemical

Product number: N0679
Product name: Ethyl (S)-(+)-3-Piperidinecarboxylate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $95
Updated: 2025/07/31

TCI Chemical

Product number: N0679
Product name: Ethyl (S)-(+)-3-Piperidinecarboxylate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $337
Updated: 2025/07/31

TRC

Product number: E926940
Product name: (S)-Ethyl piperidine-3-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: E926940
Product name: (S)-Ethyl piperidine-3-carboxylate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

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Ethyl (3S)-piperidine-3-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

Reactant for synthesis of:

DPP-4 inhibitors
JAK2 inhibitors
Serotonin and noradrenaline reuptake inhibitors
Human tryptase inhibitors
Anti-thrombotic nicecotamides

Reactive for oxidative C-arylation of free (NH)-heterocycles via direct (sp3) C-H bond functionalization

Synthesis

183316-65-6

37675-18-6

The general procedure for the synthesis of ethyl (S)-3-piperidinecarboxylate from the compound (CAS:183316-65-6) was as follows: 20.0 g of ethyl piperidinate (70.16 g, 0.446 mmol) and D-tartaric acid (67 g, 1.0 eq.) were dissolved in preheated to 95% ethanol (350 mL). The resulting solution was cooled to room temperature and then filtered and the crystals were washed with pre-cooled 95% ethanol. Subsequently, the crystals were recrystallized in 95% ethanol (550 mL) to give tartrate (38.5 g, 56% yield). The resulting tartrate (38.5 g) was dissolved in water (300 mL), cooled to 0 °C and neutralized with 3M NaOH solution. The neutralized solution was extracted with dichloromethane (5 x 100 mL), the organic phases were combined and dried with anhydrous sodium sulfate, and finally concentrated under reduced pressure to give a clarified oily product (19.0 g, 89% yield). Mass spectrometry (CIMS) analysis showed MH+ = 158.

References

[1] Patent: US2004/122018, 2004, A1. Location in patent: Page 208

Ethyl (3S)-piperidine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl (3S)-piperidine-3-carboxylate Suppliers

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View Lastest Price from Ethyl (3S)-piperidine-3-carboxylate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl (3S)-piperidine-3-carboxylate 37675-18-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-24

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl (3S)-piperidine-3-carboxylate 37675-18-6
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

Wuhan Xinhao Biotechnology Co., Ltd

Product: Ethyl (3S)-piperidine-3-carboxylate 37675-18-6
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-03-19

37675-18-6, Ethyl (3S)-piperidine-3-carboxylateRelated Search:

Ethyl nipecotate Ethylparaben Ethyl formate Benzocaine Ethyl acetate Ethyl cellulose Ethanol Ethyl acrylate Nipecotic acid Urethane Ethyl 4-piperidinecarboxylate RESMETHRIN Ethyl (S)-nipecotate L-tartrate COCAETHYLENE Piperidine Ethyl chloroformate Diethyl ether 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI)

(S)-(+)-ETHYL NIPECOTATE

(S)-ETHYL-NIPECOTATE

3-Piperidinecarboxylicacid, ethyl ester, (S)-

(3s)-(+)-ethyl Nipecotate

(S)-ETHYL PIPERIDINE-3-CARBOXYLATE

(S)-(+)-NIPECOTIC ACID ETHYL ESTER

(S)-NIPECOTIC ACID ETHYL ESTER

(S)-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER

(S)-(+)-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER

ETHYL (S)-(+)-NIPECOTATE

H-S-3PIP-OET

ETHYL (S)-(+)-3-PIPERIDINECARBOXYLATE

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ETHYL (S)-PIPERIDINE-3-CARBOXYLATE

S-Ethyl 3-piperidinecarboxylate

(S)-Piperidine-3-carboxylicacidethylesterhydrochloride

(S)-1-BOC-ETHYL NIPECOTATE

Ethyl (3S)-piperidine-3-carboxylate

(3S)-Ethyl piperidine-3-carboxylate

(S)-Ethyl piperidine-3-ca...

Ethyl (S)-nipecotate, (3S)-3-(Ethoxycarbonyl)piperidine

Ethyl L-nipecotate, 97%

Ethyl (S)-(+)-Nipecotate (S)-(+)-Nipecotic Acid Ethyl Ester (S)-(+)-3-Piperidinecarboxylic Acid Ethyl Ester

(S)-nipecotate

Ethyl(S)-(+)-3-Piperidinecarboxylate&gt

3-Piperidinecarboxylic acid, ethyl ester, (3S)-

(S)-Piperidine-3-carboxylic acid et

(<i>S</i>)-Ethyl piperidine-3-carboxylate

37675-18-6

7675-18-6

3675-18-6

Chiral Building Blocks

Esters (Chiral)

Piperidine

Heterocyclic Compounds

Chiral Building Blocks

Esters (Chiral)

Synthetic Organic Chemistry

Nitrogen cyclic compounds