Valganciclovir hydrochloride
- Product Name
- Valganciclovir hydrochloride
- CAS No.
- 175865-59-5
- Chemical Name
- Valganciclovir hydrochloride
- Synonyms
- VALGANCICLOVIR HCL;Valcyte;Valcyt;Rs 079070-194;25MG/100MG/1KG;Unii-4p3T9qf9nz;Ro 107-9070/194;Valganciclovir hydrochlorid;VALGANCICLOVIR HYDROCHLORIDE;Valgancyclovir hydrochloride
- CBNumber
- CB0380410
- Molecular Formula
- C14H23ClN6O5
- Formula Weight
- 390.82
- MOL File
- 175865-59-5.mol
Valganciclovir hydrochloride Property
- Melting point:
- 162-164°C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- H2O: ≥8mg/mL
- form
- powder
- color
- white to tan
- Stability:
- Hygroscopic
- InChIKey
- ZORWARFPXPVJLW-MTFPJWTKSA-N
- CAS DataBase Reference
- 175865-59-5
Safety
- WGK Germany
- 3
- HS Code
- 2933595960
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR1626
- Product name
- Valganciclovir Hydrochloride
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $173
- Updated
- 2024/03/01
- Product number
- 1708004
- Product name
- Valganciclovir hydrochloride hydrate
- Packaging
- 500mg
- Price
- $678
- Updated
- 2024/03/01
- Product number
- V0158
- Product name
- Valganciclovir Hydrochloride
- Packaging
- 250MG
- Price
- $48
- Updated
- 2024/03/01
- Product number
- V0158
- Product name
- Valganciclovir Hydrochloride
- Packaging
- 1G
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 13875
- Product name
- Valganciclovir (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
Valganciclovir hydrochloride Chemical Properties,Usage,Production
Description
Valganciclovir hydrochloride, a prodrug of the antiviral ganciclovir, was launched in the US for the oral treatment of cytemegalovirus (CMV) retinitis, a sight-threatening complication in patients with AIDS. This L-Valyl ester prodrug can be prepared in three steps from the nucleoside analog ganciclovir by trimethylsilyl-protection of the amino group, coupling with N-benzyloxycarbonyl-L-valine-N-carboxyanhydride, hydrolysis with hydrochloric acid and hydrogenolysis of the Cbz-protecting group. Valganciclovir is well absorbed and rapidly hydrolyzed to ganciclovir by intracellular esterases in the intestinal mucosal cells and by hepatic esterases. Unlike ganciclovir, valganciclovir was demonstrated to be actively transported by the intestinal peptide transporter PEPT1 in Caco-2 cells. As a consequence, its absolute bioavailability in human was 10-fold higher compared to ganciclovir (6%). In clinical trials, it was shown that a twice-daily 900 mg dose of valganciclovir resulted in similar systemic ganciclovir exposure to 5 mg/kg twice-daily intravenous injection of ganciclovir. Valganciclovir concentrations could not be quantified in most patients within three to four hours. In a randomized non-blind phase III clinical trial, oral valganciclovir (900 mg twice daily for three weeks then 900 mg once daily for one week) was as effective as intravenous ganciclovir (5 mg/kg twice daily for three weeks then 5 mg/kg once daily). Oral treatment with valganciclovir avoided catheter-related infection that sometimes occurred with intravenous ganciclovir.
Chemical Properties
White Crystalline Solid
Originator
Roche (Switzerland)
Uses
Valganciclovir hydrochloride hydrate may be used in HIV-related cell signaling studies.
Uses
A pro-drug of ganciclovir. Used in treatment of retro-virus
Uses
antibacterial, inhibits protein synthesis
Uses
Valganciclovir is the valyl ester prodrug of ganciclovir , an antiviral agent used for the treatment of HIV associated retinitis and for the prevention of post transplant cytomegalovirus (CMV) infections. Upon oral administration, intestinal and hepatic esterases rapidly convert valganciclovir to ganciclovir, which can inhibit viral DNA synthesis (IC50 = 0.95 μM) by targeting the CMV polymerase.
brand name
Valcyte (Roche).
General Description
Valganciclovir Hydrochloride is the L-valyl ester of ganciclovir and an antiviral drug, widely used to treat cytomegalovirus infections.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Biochem/physiol Actions
Valganciclovir hydrochloride hydrate is an antiviral used to treat cytomegalovirus infection. It is the prodrug of ganciclovir, a synthetic analog of 2′-deoxy-guanosine which is phosphorylated to a dGTP analog that competitively inhibits the incorporation of dGTP by viral DNA polymerase.
Valganciclovir hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Valganciclovir hydrochloride manufacturers
- Product
- Valganciclovir hydrochloride 175865-59-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-04-12
- Product
- Valganciclovir Hydrochloride 175865-59-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 500kgs
- Release date
- 2023-11-15
- Product
- Valganciclovir hydrochloride 175865-59-5
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kgs
- Release date
- 2021-07-09