2-Fluoro-4-methylbenzonitrile

Product Name: 2-Fluoro-4-methylbenzonitrile
CAS No.: 85070-67-3
Chemical Name: 2-Fluoro-4-methylbenzonitrile
Synonyms: 2-Fluoro-4-methylben;2-Fluoro-p-tolunitrile;4-Cyano-3-fluorotoluene;2-FLUORO-4-METHYLBENZONITRILE;2-Fluoro-4-methylbenzonitirile;2-Fluoro-4-methylbenzonitrile>Benzonitrile, 2-fluoro-4-methyl-;2-Fluoro-4-methylbenzonitrile98%;2-Fluoro-4-methylbenzonitrile 98%;2-Fluoro-4-Methylbenzenecarbonitrile
CBNumber: CB0388885
Molecular Formula: C8H6FN
Formula Weight: 135.14
MOL File: 85070-67-3.mol

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2-Fluoro-4-methylbenzonitrile Property

Melting point:: 52-53°C
Boiling point:: 219.6±20.0 °C(Predicted)
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: White to Orange to Green
Water Solubility: Insoluble in water, soluble in chloroform, acetone and other organic solvents.
InChI: InChI=1S/C8H6FN/c1-6-2-3-7(5-10)8(9)4-6/h2-4H,1H3
InChIKey: WCGNLBCJPBKXCN-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(C)C=C1F
CAS DataBase Reference: 85070-67-3(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 37/38-41-36/37/38-20/21/22
Safety Statements: 26-39-36/37-9
RIDADR: UN3439
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0884
Product name: 2-Fluoro-4-methylbenzonitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: F0884
Product name: 2-Fluoro-4-methylbenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $103
Updated: 2025/07/31

TRC

Product number: F593595
Product name: 2-Fluoro-4-methylbenzonitrile
Packaging: 2.5g
Price: $165
Updated: 2021/12/16

TRC

Product number: F593595
Product name: 2-Fluoro-4-methylbenzonitrile
Packaging: 25g
Price: $1320
Updated: 2021/12/16

Matrix Scientific

Product number: 074431
Product name: 2-Fluoro-4-methylbenzonitrile
Purity: 95+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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2-Fluoro-4-methylbenzonitrile Chemical Properties,Usage,Production

Chemical Properties

Off white crystalline

Uses

2-Fluoro-4-methylbenzonitrile is used in the synthesis of fluorobenzamidrazone thrombin inhibitors.

Synthesis

452-74-4

544-92-3

85070-67-3

Example 59 Preparation of 2-fluoro-4-methylbenzonitrile: 3-fluoro-4-bromotoluene (70 g, 370 mmol) and cuprous cyanide (50 g, 555 mmol) were dissolved in N,N-dimethylformamide (300 mL), heated to reflux and maintained for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the addition of concentrated ammonia (300 mL) and ether (200 mL) with continuous stirring for 1 hour. The reaction mixture was extracted with ether (3 x 200 mL). All organic phases were combined and washed sequentially with saturated saline (3 x 200 mL) and dried over anhydrous sodium sulfate. Finally, the solvent was removed by distillation under reduced pressure to afford the light yellow solid product 2-fluoro-4-methylbenzonitrile (44 g, 88% yield). Mass spectrometry analysis showed a molecular ion peak (M + H)+ of 136.

References

[1] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[2] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2925 - 2930
[3] Patent: WO2007/76092, 2007, A2. Location in patent: Page/Page column 74
[4] Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 7, p. 1135 - 1139
[5] Zhurnal Organicheskoi Khimii, 1992, vol. 28, # 7, p. 1439 - 1444

2-Fluoro-4-methylbenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-methylbenzonitrile Suppliers

Americas 1 Belgium 1 Canada 3 China 168 Europe 2 France 3 Germany 5 India 9 Italy 1 Japan 2 The Netherlands 1 Ukraine 1 United Kingdom 13 United States 39 Global 249

Wuhan Chiral Man Biotechnology Co., Ltd

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JinYan Chemicals(ShangHai) Co.,Ltd.

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View Lastest Price from 2-Fluoro-4-methylbenzonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Fluoro-4-methylbenzonitrile 85070-67-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Fluoro-4-methylbenzonitrile 85070-67-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Fluoro-4-methylbenzonitrile 85070-67-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

85070-67-3, 2-Fluoro-4-methylbenzonitrileRelated Search:

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Benzonitrile, 2-fluoro-4-methyl- (9CI)

2-Fluoro-4-methylbenzonitrile 98%

2-Fluoro-4-methylbenzonitrile98%

2-FLUORO-4-METHYLBENZONITRILE

2-Fluoro-4-methylbenzonitirile

2-Fluoro-4-methylben

4-Cyano-3-fluorotoluene

2-Fluoro-4-Methylbenzenecarbonitrile

4-Cyano-3-fluorotoluene, 2-Fluoro-p-tolunitrile

Benzonitrile, 2-fluoro-4-methyl-

2-Fluoro-4-methylbenzonitrile&gt

2-Fluoro-p-tolunitrile

85070-67-3

850-70-3

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NITRILE

Fluorin-contained Benzonitrile series

Miscellaneous