2-Hydrazinopyridine

Product Name: 2-Hydrazinopyridine
CAS No.: 4930-98-7
Chemical Name: 2-Hydrazinopyridine
Synonyms: 2-hydrazinylpyridine;Hydrazinopyridine;2-PYRIDYLHYDRAZINE;pyridinylhydrazine;2-HYDRAZINOPYRIDINE;pyrid-2-ylhydrazine;2-Pyridinylhydrazine;Pacritinib Impurity 7;PYRIDIN-2-YL-HYDRAZINE;Pyridine, 2-hydrazino-
CBNumber: CB0389206
Molecular Formula: C5H7N3
Formula Weight: 109.13
MOL File: 4930-98-7.mol

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2-Hydrazinopyridine Property

Melting point:: 41-44 °C (lit.)
Boiling point:: 90-92 °C/1 mmHg (lit.)
Density: 1.1118 (rough estimate)
refractive index: 1.5340 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: soluble in Methanol
pka: 9.72±0.70(Predicted)
form: crystalline
color: deep red
BRN: 109984
InChIKey: NWELCUKYUCBVKK-UHFFFAOYSA-N
CAS DataBase Reference: 4930-98-7(CAS DataBase Reference)
NIST Chemistry Reference: 2-Hydrazinopyridine(4930-98-7)
EPA Substance Registry System: 2-Hydrazinopyridine (4930-98-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10-34
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H0888
Product name: 2-Hydrazinopyridine
Purity: >98.0%(GC)(T)
Packaging: 10g
Price: $162
Updated: 2025/07/31

TCI Chemical

Product number: H0888
Product name: 2-Hydrazinopyridine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $323
Updated: 2025/07/31

Sigma-Aldrich

Product number: H17082
Product name: 2-Hydrazinopyridine
Purity: 97%
Packaging: 1g
Price: $30.34
Updated: 2025/07/31

Sigma-Aldrich

Product number: H17082
Product name: 2-Hydrazinopyridine
Purity: 97%
Packaging: 5g
Price: $117.16
Updated: 2025/07/31

Sigma-Aldrich

Product number: H17082
Product name: 2-Hydrazinopyridine
Purity: 97%
Packaging: 25g
Price: $272
Updated: 2025/07/31

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2-Hydrazinopyridine Chemical Properties,Usage,Production

Chemical Properties

White to light beige low melting solid

Synthesis Reference(s)

Journal of Medicinal Chemistry, 28, p. 1394, 1985 DOI: 10.1021/jm00148a004

Synthesis

109-09-1

4930-98-7

General procedure for the synthesis of 2-hydrazinopyridine from 2-chloropyridine: To a solution of hydrazine hydrate (200 mL, 10 vol) of 2-chloropyridine (20 g, 0.176 mol, 1 eq.), the reaction was stirred for 48 hours at 100 °C. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding reagent ratio of 8:2 ethyl acetate and methanol), and after confirming that the feedstock was completely consumed, the reaction mixture was diluted with water (200 mL) and subsequently extracted with ethyl acetate (5 x 500 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent to afford the target product 2-hydrazinopyridine (15.0 g, 78% yield) as a red oil. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.14 (1H, d, J = 3Hz, Ar-H), 7.51-7.45 (1H, m, Ar-H), 6.71-6.66 (2H, m, Ar-H), 5.78 (1H, brs, -NH), 3.81 (2H, brs, -NH2).LCMS ANALYSIS: The calculated value of C5H7N3[M+H]+ was 109.13 and the measured value was 110.1.

Purification Methods

Purify it by distillation under a vacuum and by recrystallisation from Et2O/hexane. [Kauffmann et al. Justus Liebigs Ann Chem 656 103 1962, Potts & Burton J Org Chem 31 251 1966.] The mono-hydrochloride has m 183o(dec) from aqueous HCl, and the di-hydrochloride has m 214-215o. [Beilstein 22 II 487, 22 III/IV 7025, 22/14 V 486.]

References

[1] Synthetic Communications, 2011, vol. 41, # 6, p. 925 - 938
[2] Asian Journal of Chemistry, 2017, vol. 29, # 9, p. 1920 - 1924
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 23, p. 5064 - 5069
[4] Patent: EP1380296, 2004, A1
[5] Tetrahedron Letters, 2014, vol. 55, # 52, p. 7198 - 7202

2-Hydrazinopyridine Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution 2-Bromopyridine Hydrochloric acid Dichloromethane Sodium hydroxide 4-Bromobenzaldehyde

Preparation Products

5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE ETHYL 5-AMINO-1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLATE 1-pyridin-2-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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View Lastest Price from 2-Hydrazinopyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Hydrazinylpyridine 4930-98-7
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Hydrazinopyridine 4930-98-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

Dideu Industries Group Limited

Product: 2-Hydrazinopyridine 4930-98-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

4930-98-7, 2-HydrazinopyridineRelated Search:

Chromium picolinate Pyridine 3-Aminopyridine tert-Butyl carbazate 4-Methylpyridine Carbobenzoxyhydrazide 2-Chloro-3-cyanopyridine Sulfasalazine Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 2-Bromo-6-hydrazinopyridine PYRIDINE-2-CARBOXALDEHYDE 2-QUINOLYLHYDRAZONE 6-METHYL-4-(TRIFLUOROMETHYL)PYRID-2-YL HYDRAZINE 2-Hydrazinopyridine2HCl,2-HYDRAZINOPYRIDINE DIHYDROCHLORIDE,2-HYDRAZINOPYRIDINE HYDROCHLORIDE 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]HYDRAZINE 3-HYDRAZINOPYRIDINE HYDROCHLORIDE 1-(2,3-Dimethylphenyl)piperazine 2-CHLORO-6-HYDRAZINOPYRIDINE 6-HYDRAZINO-1,3,4-TRIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE

2-HYDRAZINOPYRIDINE PYRIDIN-2-YL-HYDRAZINE

Hydrazinopyridine

2-hydrazinylpyridine

2-HYDRAZINOPYRIDINE 97+%

2-PYRIDYLHYDRAZINE

2-HYDRAZINOPYRIDINE

PYRIDIN-2-YL-HYDRAZINE

(2E)-2(1H)-Pyridinone hydrazone

2(1H)-Pyridinone, hydrazone

2(1h)-pyridinone,hydrazone

Hydrazine, 2-pyridinyl-

Pyridine, 2-hydrazino-

2-Pyridinylhydrazine

2-Hydrazinopyridine,98%

Pyridine, 2-hydrazinyl-

N-(pyridinyl)hydrazine

pyridinylhydrazine

2-Hydrazinopyridine,2-Pyridylhydrazine

2-Hydrazinopyridine 97%

2-Hydrazinopyridine, 97%, reagent grade

2-Hydrazinopyridine&gt

2-Hydrazinopyridine ISO 9001：2015 REACH

2-Hydrazinopyridine, 95% (Custom work)

pyrid-2-ylhydrazine

Pacritinib Impurity 7

4930-98-7

Heterocyclic Building Blocks

Pyridines

C5

Building Blocks

Heterocycle-Pyridine series

Heterocyclic Compounds

Pyridines, Pyrimidines, Purines and Pteredines