2-Chloro-4-bromopyridine
- Product Name
- 2-Chloro-4-bromopyridine
- CAS No.
- 73583-37-6
- Chemical Name
- 2-Chloro-4-bromopyridine
- Synonyms
- 2-CHLORO-4-F;2-chloro-4-bromopyridne;2-Bromo-2-chloropyridine;2-CHLORO-4-BROMOPYRIDINE;2-CHLORO-4-FLUOROYRIDINE;4-BROMO-2-CHLOROPYRIDINE;2-Chloro-4-boroMopyridine;PYRIDINE, 4-BROMO-2-CHLORO-;4-Bromo-2-chloropyridine 98%;4-Bromo-2-chloropyridine >
- CBNumber
- CB0425188
- Molecular Formula
- C5H3BrClN
- Formula Weight
- 192.44
- MOL File
- 73583-37-6.mol
2-Chloro-4-bromopyridine Property
- Melting point:
- 27 C
- Boiling point:
- 70 °C / 3mmHg
- Density
- 1.7336 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5900(lit.)
- Flash point:
- 225 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.24±0.10(Predicted)
- form
- Powder
- Specific Gravity
- 1.7336
- color
- Yellow
- Water Solubility
- Not miscible or difficult to mix in water.
- InChI
- InChI=1S/C5H3BrClN/c6-4-1-2-8-5(7)3-4/h1-3H
- InChIKey
- ONHMWUXYIFULDO-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(Br)=C1
- CAS DataBase Reference
- 73583-37-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41-36/37/38
- Safety Statements
- 26-36-36/37/39-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 646318
- Product name
- 4-Bromo-2-chloropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $41.4
- Updated
- 2022/05/15
- Product number
- 646318
- Product name
- 4-Bromo-2-chloropyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $136
- Updated
- 2022/05/15
- Product number
- B2951
- Product name
- 4-Bromo-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- B2951
- Product name
- 4-Bromo-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- B682210
- Product name
- 4-Bromo-2-chloro-pyridine
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
2-Chloro-4-bromopyridine Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
It is used in the synthesis of quaterpyridine nemertelline.
Synthesis
14432-12-3
73583-37-6
Step a: Synthesis of 2-chloro-4-bromopyridine To 8.9 g (69.2 mmol) of 2-chloro-4-aminopyridine was added 81.5 mL of 48% aqueous hydrobromic acid at 0 °C. Subsequently, 33.4 g (208.75 mmol) of bromine monomer was slowly added over 10 min. The reaction mixture was cooled to -10°C and 10.65 g (154 mmol) of sodium nitrite dissolved in 20 mL of water was added dropwise over 30 min. After the dropwise addition was completed, stirring was continued at -10°C for 10 minutes and then brought to room temperature and stirred for 1.5 hours. Upon completion of the reaction, the mixture was cooled to 5°C and saturated aqueous sodium sulfite solution was added until the reaction solution was colorless. The reaction solution was adjusted to alkaline with 35% sodium hydroxide aqueous solution. The basic aqueous phase was extracted twice with diethyl ether, the organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. The yellow oil obtained (13 g) was purified by silica gel column chromatography (eluent: ethyl acetate/heptane=1/9). The product was a light-colored oily substance in 52% yield. 1H NMR (CDCl3): δ 8.25 (d, 1H, J = 5Hz), 7.55 (s, 1H), 7.4 (d, 1H, J = 5Hz).
References
[1] Journal of Organic Chemistry, 2006, vol. 71, # 22, p. 8602 - 8609
[2] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[3] Patent: US2006/89364, 2006, A1. Location in patent: Page/Page column 22
[4] Roczniki Chemii, 1955, vol. 29, p. 1019,1025
[5] Chem.Abstr., 1956, p. 12045
2-Chloro-4-bromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-4-bromopyridine manufacturers
- Product
- 2-Chloro-4-bromopyridine 73583-37-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Chloro-4-bromopyridine 73583-37-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-12
- Product
- 2-Chloro-4-bromopyridine 73583-37-6
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31